Protective Effect of Potassium Against the Hypertensive Cardiac Dysfunction: Association With Reactive Oxygen Species Reduction

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 48; no. 2; pp. 225 - 231
• Main Authors: Matsui, Hiromitsu, Shimosawa, Tatsuo, Uetake, Yuzaburo, Wang, Hong, Ogura, Sayoko, Kaneko, Tomoyo, Liu, Jing, Ando, Katsuyuki, Fujita, Toshiro
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.08.2006
• Subjects: Animals; Blood Pressure - drug effects; Body Weight - drug effects; Dietary Supplements; Disease Models, Animal; Echocardiography; Heart Ventricles - metabolism; Heart Ventricles - pathology; Heart Ventricles - physiopathology; Hypertension - complications; Hypertension - diet therapy; Hypertension - physiopathology; Male; NADPH Oxidases - metabolism; Organ Size - drug effects; Potassium Chloride - administration & dosage; Potassium, Dietary - therapeutic use; Rats; Rats, Inbred Dahl; Reactive Oxygen Species - metabolism; Sodium Chloride, Dietary; Ventricular Dysfunction, Left - complications; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - prevention & control

Potassium supplementation has a potent protective effect against cardiovascular disease, but the precise mechanism of it against left ventricular abnormal relaxation, relatively early functional cardiac alteration in hypertensive subjects, has not been fully elucidated. In the present study, we inve...