Human CD8 T‐stem cell memory subsets phenotypic and functional characterization are defined by expression of CD122 or CXCR3

• Published in: European journal of immunology Vol. 51; no. 7; pp. 1732 - 1747
• Main Authors: Zhao, Yanran, Cai, Curtis, Samir, Jerome, Palgen, Jean‐Louis, Keoshkerian, Elizabeth, Li, Hui, Bull, Rowena A., Luciani, Fabio, An, Hongyan, Lloyd, Andrew R.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2021
• Subjects: Adoptive immunotherapy; antigen‐specific; CCR6 protein; CCR7 protein; CD122 antigen; CD45RA antigen; CD8 antigen; CD8 T‐memory stem cells; CD95 antigen; Cell proliferation; Cell self-renewal; CXCR3 protein; Cytokines; Flow cytometry; Immunological memory; Immunotherapy; Influenza; Interferon; Interleukin 1; multipotency; Phenotypes; polyfunctionality; proliferation; RNA sequencing; Stem cells; Surface markers; Transcription; Tumor necrosis factor; RNA sequencing; CD8 T-memory stem cells; polyfunctionality; antigen-specific; multipotency; proliferation

Long‐lived T‐memory stem cells (TSCM) are key to both naturally occurring and vaccine‐conferred protection against infection. These cells are characterized by the CD45RA+CCR7+CD95+ phenotype. Significant heterogeneity within the TSCM population is recognized, but distinguishing surface markers and f...