Blockade of PD‐1 or p38 MAP kinase signaling enhances senescent human CD8+ T‐cell proliferation by distinct pathways - Henson, Sian M.; Macaulay, Richard; Riddell, Natalie E.; Nunn, Craig J.; Akbar, Arne N. (European journal of immunology, 2015)
Keywords: Adult; Aged; Aged, 80 and over; Aging; Aging - immunology; Aging - pathology; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell Differentiation - immunology; Cell Proliferation; Cellular Senescence - immunology; Cytokines - metabolism; Histones - metabolism; Humans; Immunologic Memory; Inhibitory receptors; Kinases; Leukocyte Common Antigens - metabolism; Lymphocytes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases - immunology; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Programmed Cell Death 1 Receptor - immunology; T cells; T-Lymphocyte Subsets - cytology; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; Telomerase; Telomerase - metabolism; Young Adult; Inhibitory receptors; Aging; T cells