Paternal transmission of genetic damage: findings in animals and humans

• Published in: International journal of andrology Vol. 23; no. 3; pp. 123 - 135
• Main Author: Brinkworth, Martin H.
• Format: Journal Article
• Language: English
• Published: Oxford UK Blackwell Science Ltd 01.06.2000
• Subjects: Animals; apoptosis; Female; genomic instability; Germ-Line Mutation; Humans; Male; male germ-line mutation; male-mediated teratogenesis; Mutagens - toxicity; Paternity

The concept that mutations can be induced in the male germ‐line and result in adverse effects in the offspring has achieved only limited acceptance despite considerable theoretical appeal. This is partly because fetal malformations are generally perceived to be induced solely as a result of maternal...