Paternal transmission of genetic damage: findings in animals and humans
The concept that mutations can be induced in the male germ‐line and result in adverse effects in the offspring has achieved only limited acceptance despite considerable theoretical appeal. This is partly because fetal malformations are generally perceived to be induced solely as a result of maternal...
Saved in:
| Published in | International journal of andrology Vol. 23; no. 3; pp. 123 - 135 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Oxford UK
Blackwell Science Ltd
01.06.2000
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The concept that mutations can be induced in the male germ‐line and result in adverse effects in the offspring has achieved only limited acceptance despite considerable theoretical appeal. This is partly because fetal malformations are generally perceived to be induced solely as a result of maternally mediated events during gestation and partly because the low incidence of the end‐points concerned make experimental approaches costly and time‐consuming. Nonetheless, a substantial body of work relating to the hypothesis has accumulated in the last 20 years, which has never been reviewed in its entirety. A consideration of the available evidence indicates that preconceptional paternal exposure to mutagens (particularly radiation, cyclophosphamide and ethylnitrosourea) can indeed, under certain conditions, have adverse effects on offspring. The results suggest two principal mechanisms by which such effects may be induced: the induction of germ‐line genomic instability or the suppression of germ cell apoptosis. |
|---|---|
| AbstractList | The concept that mutations can be induced in the male germ-line and result in adverse effects in the offspring has achieved only limited acceptance despite considerable theoretical appeal. This is partly because fetal malformations are generally perceived to be induced solely as a result of maternally mediated events during gestation and partly because the low incidence of the end-points concerned make experimental approaches costly and time-consuming. Nonetheless, a substantial body of work relating to the hypothesis has accumulated in the last 20 years, which has never been reviewed in its entirety. A consideration of the available evidence indicates that preconceptional paternal exposure to mutagens (particularly radiation, cyclophosphamide and ethylnitrosourea) can indeed, under certain conditions, have adverse effects on offspring. The results suggest two principal mechanisms by which such effects may be induced: the induction of germ-line genomic instability or the suppression of germ cell apoptosis. |
| Author | Brinkworth, Martin H. |
| Author_xml | – sequence: 1 givenname: Martin H. surname: Brinkworth fullname: Brinkworth, Martin H. organization: Institute of Reproductive Medicine of the University, Domagkstraße 11, D-48129 Münster, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10844537$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkMtOwzAQRS1URB_wC8g_kOBH7CRILKpCS1EpLEAsLdd2ikvjVHEq2r_HIQixZDWjmXtGozMEPVc5AwDEKMYo4VebGFPOIsIRiwlCKEaIEBIfTsDgd9EDA4QRizjhtA-G3m9CkGYUn4E-RlmSMJoOwOxZNqZ2cgubWjpfWu9t5WBVwLVxprEKalnKtbmGhXXaurWH1kHpbCm3PlQN3_dlAM_BaREm5uKnjsDr9O5lch8tnmbzyXgRqQRREhGdY4xZnimME5ZymTCOpUQyy1KdFlJSo4s855gaxRnXPITDnGm1UpqwlI5A1t1VdeV9bQqxq8Mv9VFgJFo3YiNaBaJVIFo34tuNOAT0skN3-1Vp9B-wkxECN13g027N8d-HxfxhvAxd4KOOt74xh19e1h-CpzRl4m05E2S5mObJbSYe6RcpM4LC |
| CitedBy_id | crossref_primary_10_1016_j_urology_2010_08_038 crossref_primary_10_1158_1078_0432_CCR_10_0140 crossref_primary_10_1002_cncr_20068 crossref_primary_10_1111_j_1365_2605_2008_00933_x crossref_primary_10_1016_S2305_0500_15_30006_3 crossref_primary_10_1016_j_ctrv_2007_02_001 crossref_primary_10_3390_ijms140918078 crossref_primary_10_1111_j_2047_2927_2014_00250_x crossref_primary_10_1095_biolreprod_102_004382 crossref_primary_10_1007_s10815_006_9066_9 crossref_primary_10_1016_j_devbrainres_2003_12_010 crossref_primary_10_1097_00006250_200306000_00016 crossref_primary_10_1016_j_tree_2007_12_003 crossref_primary_10_1095_biolreprod66_4_1024 crossref_primary_10_1016_j_socscimed_2003_11_035 crossref_primary_10_1111_j_1439_0272_2012_01319_x crossref_primary_10_1002_tcm_10085 crossref_primary_10_1002_j_1939_4640_2000_tb03411_x crossref_primary_10_1186_s12610_016_0045_4 crossref_primary_10_1080_19420889_2019_1586047 crossref_primary_10_1016_j_fertnstert_2003_11_054 crossref_primary_10_1038_sj_bmt_1703651 crossref_primary_10_1134_S1062359010010024 crossref_primary_10_1093_humrep_del292 crossref_primary_10_1016_S1470_2045_07_70377_7 crossref_primary_10_1111_j_1745_7262_2005_00048_x crossref_primary_10_29252_nbr_6_4_367 crossref_primary_10_30699_jambs_28_127_97 crossref_primary_10_1002_bies_20838 crossref_primary_10_1111_j_1742_7843_2007_00162_x crossref_primary_10_1667_0033_7587_2002_157_0661_PIOSRO_2_0_CO_2 crossref_primary_10_1111_j_1745_7262_2006_00112_x crossref_primary_10_1016_j_tox_2016_04_001 crossref_primary_10_1016_j_fertnstert_2003_07_043 crossref_primary_10_1080_10884600802111671 crossref_primary_10_1046_j_1365_2605_2002_00372_x crossref_primary_10_1002_j_1939_4640_2004_tb02800_x crossref_primary_10_1016_j_mrfmmm_2006_11_020 crossref_primary_10_1093_humrep_dep223 crossref_primary_10_1667_RR3053 crossref_primary_10_1002_j_1939_4640_2001_tb03431_x crossref_primary_10_1089_dna_2009_0860 crossref_primary_10_1016_j_theriogenology_2009_09_009 crossref_primary_10_3390_toxics9070159 crossref_primary_10_4137_CMRH_S10930 crossref_primary_10_1177_205891581100200204 crossref_primary_10_1046_j_1439_0272_2003_00579_x crossref_primary_10_1111_j_1439_0272_2006_00736_x crossref_primary_10_2164_jandrol_04152 crossref_primary_10_1186_1471_2407_5_143 crossref_primary_10_1016_S0210_4806_07_73609_4 crossref_primary_10_1016_j_fertnstert_2003_04_002 crossref_primary_10_1095_biolreprod_103_016261 crossref_primary_10_1093_humrep_dep390 crossref_primary_10_1016_j_mehy_2006_04_052 crossref_primary_10_17816_ecogen2144_49 crossref_primary_10_1007_s10549_006_9424_4 crossref_primary_10_1016_j_fertnstert_2003_12_039 crossref_primary_10_1016_j_reprotox_2008_06_003 crossref_primary_10_1016_j_tiv_2006_08_008 crossref_primary_10_3109_14647273_2010_531883 crossref_primary_10_1093_humrep_17_7_1826 crossref_primary_10_1097_01_gco_0000169102_77504_66 crossref_primary_10_1371_journal_pone_0018152 crossref_primary_10_1097_01_jom_0000183343_81485_7c crossref_primary_10_1016_S0140_6736_00_05223_5 crossref_primary_10_1016_j_contraception_2005_03_004 crossref_primary_10_1097_01_jom_0000135550_47632_65 crossref_primary_10_1093_toxsci_kfi256 crossref_primary_10_18632_oncotarget_17233 |
| Cites_doi | 10.1006/taap.1999.8692 10.1016/0027-5107(90)90097-N 10.1097/00062752-199704040-00002 10.1016/S0015-0282(98)00261-1 10.1001/jama.1984.03350070021017 10.1016/S0027-5107(99)00028-7 10.1016/S0027-5107(97)00322-9 10.1111/j.1349-7006.1996.tb00199.x 10.5694/j.1326-5377.1986.tb113816.x 10.1038/bjc.1997.22 10.1016/0890-6238(93)90064-E 10.1095/biolreprod56.6.1490 10.1002/j.1939-4640.1992.tb01630.x 10.1016/S0027-5107(97)00197-8 10.1016/S0027-5107(99)00189-X 10.1080/15287398109530119 10.1016/0027-5107(90)90089-M 10.1080/09553009514550721 10.1038/367678a0 10.1016/0027-5107(88)90008-5 10.1046/j.1365-2605.1997.00056.x 10.1086/301795 10.1001/jama.1988.03720110030030 10.1080/09553009414550641 10.1016/S0027-5107(97)00196-6 10.1038/ng0993-92 10.1210/jcem.83.1.4485 10.1016/0378-4274(90)90068-W 10.1016/S0029-6465(22)00345-0 10.1095/biolreprod53.6.1465 10.1016/0027-5107(90)90096-M 10.1002/tera.1420290208 10.1093/jnci/89.3.238 10.1016/0027-5107(95)00039-L 10.1080/095530098140952 10.1016/S0027-5107(97)00199-1 10.1136/bmj.307.6897.164 10.1038/316144a0 10.1111/j.1651-2227.1997.tb18336.x 10.1073/pnas.95.11.6251 10.1038/296575a0 10.1016/0027-5107(90)90085-I 10.1007/BF01973499 10.1095/biolreprod34.2.275 10.1016/0027-5107(84)90144-1 10.1016/0165-1161(94)90044-2 10.1136/bmj.300.6722.423 10.1016/0027-5107(90)90091-H 10.1016/S0140-6736(05)70586-9 10.1093/mutage/12.3.147 10.1002/(SICI)1098-2280(1997)30:2<175::AID-EM10>3.0.CO;2-A 10.1016/0165-7992(83)90087-8 10.2307/3577440 10.1016/0027-5107(95)00251-0 10.1080/09553009514551081 10.1095/biolreprod50.1.55 10.1056/NEJM199805073381902 10.1530/jrf.0.1050025 10.1016/0027-5107(88)90159-5 10.1016/0027-5107(73)90022-5 10.1093/molehr/5.2.125 10.1073/pnas.94.16.8380 10.1002/em.2850210205 10.1111/j.1365-2605.1996.tb00523.x 10.1093/carcin/9.11.1931 10.1016/S1383-5718(99)00144-8 10.1080/095530098140998 10.1002/(SICI)1520-6866(1997)17:4/5<225::AID-TCM5>3.0.CO;2-K 10.1002/(SICI)1520-6866(1999)19:2<87::AID-TCM2>3.0.CO;2-I 10.1016/S0892-0362(96)00123-7 10.1016/0027-5107(73)90021-3 10.1038/bjc.1995.259 10.1016/S0890-6238(99)00011-8 10.1016/0300-483X(96)03436-1 10.1056/NEJM199107183250301 10.1016/0027-5107(93)90013-6 10.1002/(SICI)1520-6866(1996)16:6<301::AID-TCM2>3.0.CO;2-M 10.1016/S0027-5107(98)00242-5 10.1095/biolreprod37.2.317 10.1016/0027-5107(84)90034-4 10.1001/jama.254.5.609 10.1136/bmj.315.7117.1181 10.1038/bjc.1997.589 10.1038/ng0294-136 10.1016/S0140-6736(05)65030-1 10.1002/tera.1420450612 10.1038/380683a0 10.1016/0027-5107(90)90086-J 10.1093/ije/21.2.273 10.1016/S0378-4274(98)00312-9 10.1002/ijc.2910280413 10.1038/255077a0 10.1016/S0140-6736(05)77215-9 10.1097/00001648-199911000-00016 10.1269/jrr.32.SUPPLEMENT2_64 10.1038/bjc.1998.491 10.1002/1097-0142(19930515)71:10 <3392::AID-CNCR2820711743>3.0.CO;2-F 10.1002/(SICI)1097-0142(19990315)85:6<1380::AID-CNCR23>3.0.CO;2-O 10.1086/301677 10.1002/(SICI)1520-6866(1999)19:2<105::AID-TCM3>3.0.CO;2-K 10.1177/096032718100100104 10.1093/carcin/20.2.325 10.1007/978-1-4615-1877-8_12 10.1016/0165-1218(87)90115-7 |
| ContentType | Journal Article |
| DBID | BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION |
| DOI | 10.1046/j.1365-2605.2000.00222.x |
| DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
| DatabaseTitleList | MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1365-2605 |
| EndPage | 135 |
| ExternalDocumentID | 10_1046_j_1365_2605_2000_00222_x 10844537 IJAN222 ark_67375_WNG_2NLF94D8_M |
| Genre | reviewArticle Research Support, Non-U.S. Gov't Journal Article Review |
| GroupedDBID | --- .3N .GA .GJ .Y3 0R~ 10A 1OB 1OC 24P 29J 31~ 33P 36B 4.4 51W 51X 52M 52N 52O 52P 52R 52S 52T 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM AAHHS AANLZ AAXRX AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACMXC ACPOU ACSCC ACXBN ACXQS ADBTR ADEOM ADMGS ADOZA ADZOD AEEZP AEIGN AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFZJQ AHBTC AI. AIACR AITYG AIURR AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS AMYDB ASPBG AVWKF AZFZN BDRZF BFHJK BRXPI BSCLL BY8 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DR2 DRFUL DRMAN DRSTM DU5 EAD EAP EAS EBC EBD EBS EBX EJD EMB EMK EMOBN EPT ESX EX3 F00 F01 F04 F5P FEDTE G-S GODZA HF~ HGLYW HOLLA HVGLF HZI IHE IX1 J0M L7B LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MXFUL MXMAN MXSTM N9A O9- OIG OK1 OVD P2P P2X P2Z P4B P4D Q11 QB0 Q~Q RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 V8K VH1 W8V W99 WIH WIJ WIK WIN WOW WQJ WRC WUP WXI WXSBR WYUIH XG1 YFH YOC YUY ZZTAW ~KM CGR CUY CVF ECM EIF NPM AAMNL AAYXX ACRPL ACYXJ CITATION |
| ID | FETCH-LOGICAL-c4032-2d9111598c114576a4561aa0a887d7faa3edf99613ec656d6115d7f5dcbcd2573 |
| IEDL.DBID | DR2 |
| ISSN | 0105-6263 |
| IngestDate | Fri Dec 06 01:28:55 EST 2024 Sat Sep 28 07:35:37 EDT 2024 Sat Aug 24 01:00:10 EDT 2024 Wed Oct 30 09:53:30 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4032-2d9111598c114576a4561aa0a887d7faa3edf99613ec656d6115d7f5dcbcd2573 |
| Notes | ArticleID:IJAN222 ark:/67375/WNG-2NLF94D8-M istex:B30EC371D25F20EA9E20AFD4B135D023569F207F |
| PMID | 10844537 |
| PageCount | 13 |
| ParticipantIDs | crossref_primary_10_1046_j_1365_2605_2000_00222_x pubmed_primary_10844537 wiley_primary_10_1046_j_1365_2605_2000_00222_x_IJAN222 istex_primary_ark_67375_WNG_2NLF94D8_M |
| PublicationCentury | 2000 |
| PublicationDate | June 2000 |
| PublicationDateYYYYMMDD | 2000-06-01 |
| PublicationDate_xml | – month: 06 year: 2000 text: June 2000 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford UK |
| PublicationPlace_xml | – name: Oxford UK – name: England |
| PublicationTitle | International journal of andrology |
| PublicationTitleAlternate | Int J Androl |
| PublicationYear | 2000 |
| Publisher | Blackwell Science Ltd |
| Publisher_xml | – name: Blackwell Science Ltd |
| References | Barnes, C. J., Covington, B. W.IVth, Cameron, I. L., Lee, M. (1998) Effect of aging on spontaneous and induced mouse testicular germ cell apoptosis. Aging (Milano) 10, 497 501. Austin, S. M., Robaire, B., Hales, B. F., Kelly, S. M. (1994) Paternal cyclophosphamide exposure causes decreased cell proliferation in cleavage-stage embryos. Biology of Reproduction 50, 55 64. Hikim, A. P., Wang, C., Lue, Y., Johnson, L., Wang, X. H., Swerdloff, R. S. (1998) Spontaneous germ cell apoptosis in humans: evidence for ethnic differences in the susceptibility of germ cells to programmed cell death. Journal of Clinical Endocrinology and Metabolism 83, 152 156. Dodds, L., Marrett, L. D., Tomkins, D. J., Green, B., Sherman, G. (1993) Case-control study of congenital anomalies in children of cancer patients. British Medical Journal 307, 164 168. Mohr, U., Dasenbrock, C., Tillmann, T., Kohler, M., Kamino, K., Hagemann, G. et al. (1999) Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice. Carcinogenesis 20, 325 332. Edwards, A. J., Anderson, D., Brinkworth, M. H., Myers, B., Parry, J. M. (1999) An investigation of male-mediated F1 effects in mice treated acutely and sub-chronically with urethane. Teratogenesis, Carcinogenesis, and Mutagenesis 19, 87 103. Pacchierotti, F., Adler, I. D., Anderson, D., Brinkworth, M., Demopoulos, N. A., Lahdetie, J. et al. (1998) Genetic effects of 1,3-butadiene and associated risk for heritable damage. Mutation Research 397, 93 115. Ji, B. T., Shu, X. O., Linet, M. S., Zheng, W., Wacholder, S., Gao, Y. T., Ying, D. M., Jin, F. (1997) Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers. Journal of the National Cancer Institute 89, 238 244. Cohen, F. L. (1986) Paternal contributions to birth defects. Nursing Clinics of North America 21, 49 64. Lord, B. I., Woolford, L. B., Wang, L., McDonald, D., Lorimore, S. A., Stones, V. A., Wright, E. G., Scott, D. (1998a) Induction of lympho-haemopoietic malignancy: impact of preconception paternal irradiation. International Journal of Radiation Biology 74, 721 728. Holland, N., Ahlborn, T., Turteltaub, K., Markee, C., Moore, D.2nd, Wyrobek, A. J., Smith, M. T. (1999) Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice. Reproductive Toxicology 13, 167 178. Shoji, S., Masaoka, Y., Kurosumi, M., Katoh, O., Watanabe, H. (1998) Tumorigenesis in F1 offspring mice following paternal 12.5 cGy 252Cf fission neutron irradiation. Oncology Reports 5, 1175 1178. Jenkinson, P. C., Anderson, D., Gangolli, S. D. (1987) Increased incidence of abnormal fetuses in the offspring of cyclophosphamide-treated male mice. Mutation Research 188, 57 62. Nagao, T. & Fujikawa, K. (1990) Genotoxic potency in mouse spermatogonial stem cells of triethylenemelamine, mitomycin C, ethylnitrosourea, procarbazine, and propyl methanesulfonate as measured by F1 congenital defects. Mutation Research 229, 123 128. Qiu, J., Hales, B. F., Robaire, B. (1995) Damage to rat spermatozoal DNA after chronic cyclophosphamide exposure. Biology of Reproduction 53, 1465 1473. Crow, J. F. (1995) Spontaneous mutation as a risk factor. Experimental and Clinical Immunogenetics 12, 121 128. Rubes, J., Lowe, X., Moore, D.2nd, Perreault, S., Slott, V., Evenson, D., Selevan, S. G., Wyrobek, A. J. (1998) Smoking cigarettes is associated with increased sperm disomy in teenage men. Fertility and Sterility 70, 715 723. Hartwig, A. (1998) Carcinogenicity of metal compounds: possible role of DNA repair inhibition. Toxicology Letters 102-103, 235 239. Trasler, J. M., Hales, B. F., Robaire, B. (1987) A time-course study of chronic paternal cyclophosphamide treatment in rats: effects on pregnancy outcome and the male reproductive and hematologic systems. Biology of Reproduction 37, 317 326. Sankila, R., Olsen, J. H., Anderson, H., Garwicz, S., Glattre, E., Hertz, H., Langmark, F., Lanning, M., Moller, T., Tulinius, H. (1998) Risk of cancer among offspring of childhood-cancer survivors. Association of the Nordic Cancer Registries and the Nordic Society of Paediatric Haematology and Oncology. New England Journal of Medicine 338, 1339 1344. Rogan, W. J., Gladen, B. C., Guo, Y. L., Hsu, C. C. (1999) Sex ratio after exposure to dioxin-like chemicals in Taiwan. Lancet 353, 206 207. Byrne, J., Rasmussen, S. A., Steinhorn, S. C., Connelly, R. R., Myers, M. H., Lynch, C. F. et al. (1998) Genetic disease in offspring of long-term survivors of childhood and adolescent cancer. American Journal of Human Genetics 62, 45 52. Benlian, P., Foubert, L., Gagne, Bernard, L., De Gennes, J. L., Langlois, S., Robinson, W., Hayden, M. (1996) Complete paternal isodisomy for chromosome 8 unmasked by lipoprotein lipase deficiency. American Journal of Human Genetics 59, 431 436. Green, D., Howells, G. R., Humphreys, E. R., Vennart, J. (1975) Localisation of plutonium in mouse testes. Nature 255, 7777. Nelson, B. K., Moorman, W. J., Schrader, S. M. (1996) Review of experimental male-mediated behavioral and neurochemical disorders. Neurotoxicology and Teratology 18, 611 616. Short, R. V. (1997) The testis: the witness of the mating system, the site of mutation and the engine of desire. Acta Paediatrica Supplement 422, 3 7. Anderson, D., Bishop, J. B., Garner, R. C., Ostrosky-Wegman, P., Selby, P. B. (1995) Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks. Mutation Research 330, 115 181. Anderson, D., Edwards, A. J., Brinkworth, M. H., Hughes, J. A. (1996) Male-mediated F1 effects in mice exposed to 1,3-butadiene. Toxicology 113, 120 127. Dubrova, Y. E., Plumb, M., Brown, J., Fennelly, J., Bois, P., Goodhead, D., Jeffreys, A. J. (1998a) Stage specificity, dose response, and doubling dose for mouse minisatellite germ-line mutation induced by acute radiation. Proceedings of the National Academy of Sciences of the USA 95, 6251 6255. Nagao, T. & Fujikawa, K. (1996) Male-mediated teratogenesis: spectrum of congenital malformations in the offspring of A/J male mice treated with ethylnitrosourea. Teratogenesis, Carcinogenesis, and Mutagenesis 16, 301 305. Infante-Rivard, C. & Sinnett, D. (1999) Preconceptional paternal exposure to pesticides and increased risk of childhood leukaemia. Lancet 354, 1819 1820. Borovskaia, T. G., Smirnova, M. E., Filippova, M. V., Fomina, T. I., Gol'Dberg, V. E. (1996) The late effects of the toxic action of platinum-containing cytostatic preparations on rat progeny. Eksperimentalnaia I Klinicheskaia Farmakologiia 59, 40 42. Selby, P. B. (1973b) X-ray-induced specific-locus mutation rates in young male mice. Mutation Research 18, 77 88. Little, J. & Vainio, H. (1994) Mutagenic lifestyles? A review of evidence of associations between germ-cell mutations in humans and smoking, alcohol consumption and use of 'recreational' drugs. Mutation Research 313, 131 151. Jeffreys, A. J., Tamaki, K., MacLeod, A., Monckton, D. G., Neil, D. L., Armour, J. A. (1994) Complex gene conversion events in germline mutation at human minisatellites. Nature Genetics 6, 136 145. Ehling, U. H. (1989) Germ Cell Mutations in Mice. IARC Scientific Publications 96, 207 219. Cai, L., Hales, B. F., Robaire, B. (1997) Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophosphamide. Biology of Reproduction 56, 1490 1497. Dubrova, Y. E., Plumb, M., Brown, J., Jeffreys, A. J. (1998b) Radiation-induced germline instability at minisatellite loci. International Journal of Radiation Biology 74, 689 696. Sterling, T. D. & Arundel, A. (1985) Vietnam veterans risk for fathering children with birth defects. Jama 254, 609 610. Sadamoto, S., Suzuki, S., Kamiya, K., Kominami, R., Dohi, K., Niwa, O. (1994) Radiation induction of germline mutation at a hypervariable mouse minisatellite locus. International Journal of Radiation Biology 65, 549 557. Cattanach, B. M., Patrick, G., Papworth, D., Goodhead, D. T., Hacker, T., Cobb, L., Whitehill, E. (1995) Investigation of lung tumour induction in BALB/cJ mice following paternal X-irradiation. International Journal of Radiation Biology 67, 607 615. Armour, J. A., Brinkworth, M. H., Klamischke, A. (1999) Direct analysis by small-pool PCR of MS205 minisatellite mutation rates in sperm after mutagenic therapies. Mutation Research 445, 73 80. Nomura, T. (1983) X-ray-induced germ-line mutation leading to tumors. Its manifestation in mice given urethane post-natally. Mutation Research 121, 59 65. Stevens, K. M. (1981) Agent Orange toxicity: a quantitative perspective. Human Toxicology 1, 31 39. Dubrova, Y. E., Nesterov, V. N., Krouchinsky, N. G., Ostapenko, V. A., Neumann, R., Neil, D. L., Jeffreys, A. J. (1996) Human minisatellite mutation rate after the Chernobyl accident. Nature 380, 683 686. Needham, L. L., Gerthoux, P. M., Patterson, D. G.Jr, Brambilla, P., Turner, W. E., Beretta, C. et al. (1997) Serum dioxin levels in Seveso, Italy, population in 1976. Teratogenesis, Carcinogenesis, and Mutagenesis 17, 225 240. Fan, Y. J., Wang, Z., Sadamoto, S., Ninomiya, Y., Kotomura, N., Kamiya, K., Dohi, K., Kominami, R., Niwa, O. (1995) Dose-response of a radiation induction of a germline mutation at a hypervariable mouse minisatellite locus. International Journal of Radiation Biology 68, 177 183. Brzustowicz, L. M., Allitto, B. A., Matseoane, D., Theve, R., Michaud, L., Chatkupt, S. et al. (1994) Paternal isodisomy for chromosome 5 in a child with spinal muscular atrophy. American Journal of Human Genetics 54, 482 488. Jenkinson, P. C. & Anderson, D. (1990) Malformed fetuses and karyotype abnormalities in the offspring of cyclophosphamide and allyl alcohol-treated male rats. Mutation Research 229, 173 184. Watanabe, H., Takahashi, T., Lee, J. Y., Ohtaki, M., Roy, G., Ando, Y. et al. (1996) Influence of paternal (252) Cf neutron exposure on abnormal sperm, embryonal lethality, and liver tumorigenesis in the F(1) offspring of mice. Japanese Journal of Cancer Research 87, 51 57. Nicholson, H. S 1990; 51 1990; 229 1997; 315 1989; 118 1987; 188 1993; 21 1996; 380 1998; 83 1998; 397 1999; 445 1997b; 76 1997; 4 1994; 65 1987; 37 1997; 422 1987; 41 1997; 56 1973b; 18 1998; 10 1992; 45 1995; 53 1996; 18 1994; 313 1996; 19 1997; 20 1981; 1 1988; 202 1981; 8 1994 1999; 20 1981; 28 1998; 62 1996; 16 1998a; 74 1983; 121 1991; 65 1986; 21 1997; 30 1998; 70 1996; 351 1999; 353 1985; 316 1999; 354 1992; 21 1996; 113 1991; 325 1998; 5 1996; 87 1993; 7 1995; 71 1984; 125 1986; 34 1984; 127 1997; 89 1984; 29 1992; 13 1999; 85 1995; 330 1990; 300 1998a; 95 1993; 5 1996; 348 1993; 287 1997; 94 1973a; 18 1999; 19 1986; 145 1993; 71 2000; 447 1995; 68 1995; 67 1997; 12 1999; 13 1997; 17 1982; 296 1999; 10 1998; 403 1988; 259 1985; 254 1980; 28 1993; 307 1991; 32 1995; 12 1998; 338 1998b; 74 1975; 255 1999; 8 1999; 425 1999; 423 1996; 59 1999; 5 1989; 96 1984; 252 1994; 367 1988; 9 1998b; 78 1998; 102–103 1997a; 75 1995; 105 1988; 198 1999; 158 1994; 50 1994; 54 1994; 6 e_1_2_8_49_2 e_1_2_8_45_2 e_1_2_8_68_2 e_1_2_8_5_2 e_1_2_8_41_2 Hikim A. P. (e_1_2_8_50_2) 1998; 83 e_1_2_8_87_2 e_1_2_8_22_2 e_1_2_8_64_2 e_1_2_8_83_2 e_1_2_8_60_2 e_1_2_8_113_2 e_1_2_8_38_2 e_1_2_8_19_2 e_1_2_8_109_2 e_1_2_8_34_2 e_1_2_8_15_2 e_1_2_8_57_2 e_1_2_8_91_2 e_1_2_8_99_2 e_1_2_8_30_2 e_1_2_8_76_2 e_1_2_8_105_2 e_1_2_8_53_2 e_1_2_8_72_2 e_1_2_8_101_2 Brzustowicz L. M. (e_1_2_8_18_2) 1994; 54 e_1_2_8_29_2 e_1_2_8_25_2 e_1_2_8_48_2 e_1_2_8_67_2 Risch N. (e_1_2_8_85_2) 1987; 41 e_1_2_8_2_2 e_1_2_8_110_2 e_1_2_8_6_2 e_1_2_8_21_2 e_1_2_8_44_2 e_1_2_8_63_2 e_1_2_8_86_2 e_1_2_8_40_2 e_1_2_8_82_2 e_1_2_8_114_2 e_1_2_8_14_2 e_1_2_8_37_2 e_1_2_8_56_2 e_1_2_8_79_2 Bisanti L. (e_1_2_8_11_2) 1980; 28 Benlian P. (e_1_2_8_10_2) 1996; 59 e_1_2_8_90_2 e_1_2_8_94_2 e_1_2_8_98_2 e_1_2_8_33_2 e_1_2_8_52_2 e_1_2_8_75_2 e_1_2_8_106_2 Mastroiacovo P. (e_1_2_8_65_2) 1988; 259 e_1_2_8_71_2 e_1_2_8_102_2 e_1_2_8_28_2 Borovskaia T. G. (e_1_2_8_12_2) 1996; 59 e_1_2_8_47_2 e_1_2_8_89_2 e_1_2_8_3_2 e_1_2_8_7_2 e_1_2_8_20_2 e_1_2_8_115_2 e_1_2_8_43_2 Cohen F. L. (e_1_2_8_24_2) 1986; 21 e_1_2_8_62_2 Meinert R. (e_1_2_8_66_2) 1999; 8 e_1_2_8_111_2 e_1_2_8_81_2 e_1_2_8_17_2 Barnes C. J. (e_1_2_8_9_2) 1998; 10 e_1_2_8_13_2 Ehling U. H. (e_1_2_8_36_2) 1989; 96 e_1_2_8_59_2 e_1_2_8_78_2 e_1_2_8_97_2 e_1_2_8_55_2 e_1_2_8_32_2 e_1_2_8_74_2 e_1_2_8_107_2 e_1_2_8_51_2 e_1_2_8_93_2 e_1_2_8_70_2 e_1_2_8_103_2 e_1_2_8_27_2 Shoji S. (e_1_2_8_95_2) 1998; 5 e_1_2_8_23_2 e_1_2_8_46_2 e_1_2_8_69_2 e_1_2_8_80_2 e_1_2_8_4_2 e_1_2_8_8_2 e_1_2_8_42_2 e_1_2_8_88_2 e_1_2_8_61_2 e_1_2_8_84_2 e_1_2_8_112_2 e_1_2_8_16_2 e_1_2_8_39_2 e_1_2_8_35_2 e_1_2_8_58_2 e_1_2_8_108_2 e_1_2_8_96_2 e_1_2_8_31_2 e_1_2_8_54_2 e_1_2_8_77_2 e_1_2_8_104_2 e_1_2_8_73_2 e_1_2_8_100_2 Crow J. F. (e_1_2_8_26_2) 1995; 12 e_1_2_8_92_2 |
| References_xml | – volume: 13 start-page: 167 year: 1999 end-page: 178 article-title: Acrylamide causes preimplantation abnormalities in embryos and induces chromatin‐adducts in male germ cells of mice publication-title: Reproductive Toxicology – volume: 445 start-page: 73 year: 1999 end-page: 80 article-title: Direct analysis by small‐pool PCR of MS205 minisatellite mutation rates in sperm after mutagenic therapies publication-title: Mutation Research – volume: 4 start-page: 227 year: 1997 end-page: 232 article-title: Epidemiology of childhood leukemia publication-title: Current Opinions in Hematology – volume: 65 start-page: 549 year: 1994 end-page: 557 article-title: Radiation induction of germline mutation at a hypervariable mouse minisatellite locus publication-title: International Journal of Radiation Biology – volume: 19 start-page: 323 year: 1996 end-page: 337 article-title: Smoking and male reproduction: a review publication-title: International Journal of Andrology – volume: 7 start-page: 3 year: 1993 end-page: 16 article-title: Methods and concepts in detecting abnormal reproductive outcomes of paternal origin publication-title: Reproductive Toxicology – volume: 59 start-page: 431 year: 1996 end-page: 436 article-title: Complete paternal isodisomy for chromosome 8 unmasked by lipoprotein lipase deficiency publication-title: American Journal of Human Genetics – volume: 37 start-page: 317 year: 1987 end-page: 326 article-title: A time‐course study of chronic paternal cyclophosphamide treatment in rats: effects on pregnancy outcome and the male reproductive and hematologic systems publication-title: Biology of Reproduction – volume: 50 start-page: 55 year: 1994 end-page: 64 article-title: Paternal cyclophosphamide exposure causes decreased cell proliferation in cleavage‐stage embryos publication-title: Biology of Reproduction – volume: 30 start-page: 175 year: 1997 end-page: 183 article-title: Use of fluorescence in situ hybridization (FISH) to assess effects of smoking, caffeine, and alcohol on aneuploidy load in sperm of healthy men publication-title: Environmental and Molecular Mutagenesis – volume: 74 start-page: 721 year: 1998a end-page: 728 article-title: Induction of lympho‐haemopoietic malignancy: impact of preconception paternal irradiation publication-title: International Journal of Radiation Biology – volume: 397 start-page: 67 year: 1998 end-page: 75 article-title: Genetic effects of 1,3‐butadiene on the mouse testis publication-title: Mutation Research – volume: 202 start-page: 25 year: 1988 end-page: 33 article-title: Congenital defects in the offspring of male mice treated with ethylnitrosourea publication-title: Mutation Research – volume: 296 start-page: 575 year: 1982 end-page: 577 article-title: Parental exposure to x rays and chemicals induces heritable tumours and anomalies in mice publication-title: Nature – volume: 121 start-page: 59 year: 1983 end-page: 65 article-title: X‐ray‐induced germ‐line mutation leading to tumors. Its manifestation in mice given urethane post‐natally publication-title: Mutation Research – volume: 28 start-page: 139 year: 1980 end-page: 157 article-title: Experiences from the accident of Seveso publication-title: Acta Morphologica Academiae Scientiarum Hungaricae – volume: 76 start-page: 1525 year: 1997b end-page: 1531 article-title: Childhood cancer and parental use of tobacco: deaths from 1971 to 1976 publication-title: British Journal of Cancer – volume: 94 start-page: 8380 year: 1997 end-page: 8386 article-title: The high spontaneous mutation rate: is it a health risk? publication-title: Proceedings of the National Academy of Sciences of the USA – volume: 229 start-page: 173 year: 1990 end-page: 184 article-title: Malformed fetuses and karyotype abnormalities in the offspring of cyclophosphamide and allyl alcohol‐treated male rats publication-title: Mutation Research – volume: 83 start-page: 152 year: 1998 end-page: 156 article-title: Spontaneous germ cell apoptosis in humans: evidence for ethnic differences in the susceptibility of germ cells to programmed cell death publication-title: Journal of Clinical Endocrinology and Metabolism – volume: 259 start-page: 1668 year: 1988 end-page: 1672 article-title: Birth defects in the Seveso area after TCDD contamination publication-title: Jama – volume: 74 start-page: 689 year: 1998b end-page: 696 article-title: Radiation‐induced germline instability at minisatellite loci publication-title: International Journal of Radiation Biology – volume: 229 start-page: 239 year: 1990 end-page: 246 article-title: Tumours and malformations in the adult offspring of cyclophosphamide‐treated and control male rats – preliminary communication publication-title: Mutation Research – volume: 145 start-page: 219 year: 1986 end-page: 225 article-title: The Agent Orange controversy after the Evatt Royal Commission publication-title: Medical Journal of Australia – volume: 252 start-page: 903 year: 1984 end-page: 912 article-title: Vietnam veterans’ risks for fathering babies with birth defects publication-title: Jama – volume: 85 start-page: 1380 year: 1999 end-page: 1388 article-title: Parental cigarette smoking and the risk of acute leukemia in children publication-title: Cancer – volume: 8 start-page: 835 year: 1981 end-page: 844 article-title: Development and viability of offspring of male mice treated with chlorinated phenoxy acids and 2,3,7,8‐tetrachlorodibenzo‐, p.‐dioxin publication-title: Journal of Toxicology and Environmental Health – volume: 34 start-page: 275 year: 1986 end-page: 283 article-title: Chronic low dose cyclophosphamide treatment of adult rats: effect on fertility, pregnancy outcome and progeny publication-title: Biology of Reproduction – volume: 71 start-page: 1335 year: 1995 end-page: 1339 article-title: Cancer in the offspring of survivors of childhood leukaemia and non‐Hodgkin lymphomas publication-title: British Journal of Cancer – volume: 59 start-page: 40 year: 1996 end-page: 42 article-title: The late effects of the toxic action of platinum‐containing cytostatic preparations on rat progeny publication-title: Eksperimentalnaia I Klinicheskaia Farmakologiia – volume: 9 start-page: 1931 year: 1988 end-page: 1934 article-title: Urethane‐induced lung adenomas in the first‐generation progeny of irradiated male mice publication-title: Carcinogenesis – volume: 53 start-page: 1465 year: 1995 end-page: 1473 article-title: Damage to rat spermatozoal DNA after chronic cyclophosphamide exposure publication-title: Biology of Reproduction – volume: 307 start-page: 164 year: 1993 end-page: 168 article-title: Case‐control study of congenital anomalies in children of cancer patients publication-title: British Medical Journal – volume: 95 start-page: 6251 year: 1998a end-page: 6255 article-title: Stage specificity, dose response, and doubling dose for mouse minisatellite germ‐line mutation induced by acute radiation publication-title: Proceedings of the National Academy of Sciences of the USA – volume: 403 start-page: 1 year: 1998 end-page: 12 article-title: Investigation of lung tumour induction in C3H/HeH mice, with and without tumour promotion with urethane, following paternal X‐irradiation publication-title: Mutation Research – volume: 65 start-page: 27 year: 1991 end-page: 31 article-title: Reproductive toxicity and toxicokinetics of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. 2. Problem of paternally‐mediated abnormalities in the progeny of rat publication-title: Archives of Toxicology – volume: 12 start-page: 147 year: 1997 end-page: 152 article-title: Genomic instability in haematopoietic cells of F1 generation mice of irradiated male parents publication-title: Mutagenesis – volume: 89 start-page: 238 year: 1997 end-page: 244 article-title: Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers publication-title: Journal of the National Cancer Institute – volume: 75 start-page: 134 year: 1997a end-page: 138 article-title: Childhood cancer and parental use of tobacco: deaths from 1953 to 1955 publication-title: British Journal of Cancer – volume: 10 start-page: 497 year: 1998 end-page: 501 article-title: Effect of aging on spontaneous and induced mouse testicular germ cell apoptosis publication-title: Aging (Milano) – volume: 351 start-page: 199 year: 1996 end-page: 203 article-title: Smoking and low antioxidant levels increase oxidative damage to sperm DNA publication-title: Mutation Research – volume: 113 start-page: 120 year: 1996 end-page: 127 article-title: Male‐mediated F1 effects in mice exposed to 1,3‐butadiene publication-title: Toxicology – volume: 188 start-page: 57 year: 1987 end-page: 62 article-title: Increased incidence of abnormal fetuses in the offspring of cyclophosphamide‐treated male mice publication-title: Mutation Research – volume: 397 start-page: 77 year: 1998 end-page: 84 article-title: A comparison of male‐mediated effects in rats and mice exposed to 1,3‐butadiene publication-title: Mutation Research – volume: 348 start-page: 409 year: 1996 end-page: 409 article-title: Change in sex ratio with exposure to dioxin publication-title: Lancet – volume: 54 start-page: 482 year: 1994 end-page: 488 article-title: Paternal isodisomy for chromosome 5 in a child with spinal muscular atrophy publication-title: American Journal of Human Genetics – volume: 102–103 start-page: 235 year: 1998 end-page: 239 article-title: Carcinogenicity of metal compounds: possible role of DNA repair inhibition publication-title: Toxicology Letters – volume: 67 start-page: 607 year: 1995 end-page: 615 article-title: Investigation of lung tumour induction in BALB/cJ mice following paternal X‐irradiation publication-title: International Journal of Radiation Biology – volume: 397 start-page: 93 year: 1998 end-page: 115 article-title: Genetic effects of 1,3‐butadiene and associated risk for heritable damage publication-title: Mutation Research – volume: 105 start-page: 25 year: 1995 end-page: 33 article-title: Identification of male germ cells undergoing apoptosis in adult rats publication-title: Journal of Reproduction and Fertility – volume: 229 start-page: 144 year: 1990 end-page: 159 article-title: High resolution metrical analysis applied to the assessment of damage associated with induced mutations in the mouse publication-title: Mutation Research – volume: 325 start-page: 141 year: 1991 end-page: 146 article-title: Congenital anomalies in children of patients who received chemotherapy for cancer in childhood and adolescence publication-title: New England Journal of Medicine – volume: 78 start-page: 301 year: 1998b end-page: 311 article-title: Tumour induction by methyl‐nitroso‐urea following preconceptional paternal contamination with plutonium‐239 publication-title: British Journal of Cancer – volume: 158 start-page: 161 year: 1999 end-page: 176 article-title: Preconception urethane or chromium (III) treatment of male mice: multiple neoplastic and non‐plastic changes in offspring publication-title: Toxicology and Applied Pharmacology – volume: 447 start-page: 149 year: 2000 end-page: 154 article-title: Association of cyclophosphamide‐induced male‐mediated, foetal abnormalities with reduced paternal germ‐cell apoptosis publication-title: Mutation Research – volume: 96 start-page: 207 year: 1989 end-page: 219 article-title: Germ Cell Mutations in Mice publication-title: IARC Scientific Publications – volume: 198 start-page: 309 year: 1988 end-page: 320 article-title: X‐ray‐ and chemically induced germ‐line mutation causing phenotypical anomalies in mice publication-title: Mutation Research – volume: 13 start-page: 65 year: 1992 end-page: 74 article-title: Effects of subchronic treatment with cis‐platinum on testicular function, fertility, pregnancy outcome, and progeny publication-title: Journal of Andrology – volume: 5 start-page: 1175 year: 1998 end-page: 1178 article-title: Tumorigenesis in F1 offspring mice following paternal 12.5 cGy 252Cf fission neutron irradiation publication-title: Oncology Reports – volume: 127 start-page: 93 year: 1984 end-page: 105 article-title: Non‐breeding‐test methods for dominant skeletal mutations shown by ethylnitrosourea to be easily applicable to offspring examined in specific‐locus experiments publication-title: Mutation Research – volume: 425 start-page: 99 year: 1999 end-page: 106 article-title: Radiation‐induced malformations after exposure of murine germ cells in various stages of spermatogenesis publication-title: Mutation Research – volume: 62 start-page: 848 year: 1998 end-page: 854 article-title: Paternal uniparental disomy for chromosome 1 revealed by molecular analysis of a patient with pycnodysostosis publication-title: American Journal of Human Genetics – volume: 229 start-page: 231 year: 1990 end-page: 237 article-title: Tumour incidence in the progeny of male rats exposed to ethylnitrosourea before mating publication-title: Mutation Research – volume: 315 start-page: 1181 year: 1997 end-page: 1188 article-title: Cancer in the offspring of radiation workers: a record linkage study publication-title: British Medical Journal – volume: 6 start-page: 136 year: 1994 end-page: 145 article-title: Complex gene conversion events in germline mutation at human minisatellites publication-title: Nature Genetics – volume: 41 start-page: 218 year: 1987 end-page: 248 article-title: Spontaneous mutation and parental age in humans publication-title: American Journal of Human Genetics – volume: 17 start-page: 225 year: 1997 end-page: 240 article-title: Serum dioxin levels in Seveso, Italy, population in 1976 publication-title: Teratogenesis, Carcinogenesis, and Mutagenesis – volume: 367 start-page: 678 year: 1994 end-page: 680 article-title: Paternal exposure not to blame publication-title: Nature – volume: 354 start-page: 1819 year: 1999 end-page: 1820 article-title: Preconceptional paternal exposure to pesticides and increased risk of childhood leukaemia publication-title: Lancet – volume: 118 start-page: 246 year: 1989 end-page: 256 article-title: A chimera embryo assay reveals a decrease in embryonic cellular proliferation induced by sperm from X‐irradiated male mice publication-title: Radiation Research – volume: 255 start-page: 77 year: 1975 end-page: 77 article-title: Localisation of plutonium in mouse testes publication-title: Nature – volume: 5 start-page: 92 year: 1993 end-page: 94 article-title: Mouse minisatellite mutations induced by ionizing radiation publication-title: Nature Genetics – volume: 287 start-page: 207 year: 1993 end-page: 216 article-title: Promotion of skin tumors by 12‐O‐tetradecanoylphorbol‐13‐acetate in two generations of descendants of male mice exposed to X‐ray irradiation publication-title: Mutation Research – volume: 29 start-page: 193 year: 1984 end-page: 221 article-title: Does Agent Orange cause birth defects? publication-title: Teratology – volume: 380 start-page: 683 year: 1996 end-page: 686 article-title: Human minisatellite mutation rate after the Chernobyl accident publication-title: Nature – volume: 45 start-page: 671 year: 1992 end-page: 678 article-title: Increased postimplantation loss and malformations among the F2 progeny of male rats chronically treated with cyclophosphamide publication-title: Teratology – year: 1994 – volume: 18 start-page: 77 year: 1973b end-page: 88 article-title: X‐ray‐induced specific‐locus mutation rates in young male mice publication-title: Mutation Research – volume: 12 start-page: 121 year: 1995 end-page: 128 article-title: Spontaneous mutation as a risk factor publication-title: Experimental and Clinical Immunogenetics – volume: 32 start-page: 64 year: 1991 end-page: 72 article-title: Paternal exposure to radiation and offspring cancer in mice: reanalysis and new evidence publication-title: Journal of Radiation Research (Tokyo) – volume: 313 start-page: 131 year: 1994 end-page: 151 article-title: Mutagenic lifestyles? A review of evidence of associations between germ‐cell mutations in humans and smoking, alcohol consumption and use of ‘recreational’ drugs publication-title: Mutation Research – volume: 21 start-page: 273 year: 1992 end-page: 278 article-title: A case‐control study of paternal smoking and birth defects publication-title: International Journal of Epidemiology – volume: 10 start-page: 747 year: 1999 end-page: 751 article-title: Parental age and risk of sporadic and familial cancer in offspring: implications for germ cell mutagenesis publication-title: Epidemiology – volume: 18 start-page: 63 year: 1973a end-page: 75 article-title: X‐ray‐induced specific‐locus mutation rate in newborn male mice publication-title: Mutation Research – volume: 8 start-page: 793 year: 1999 end-page: 799 article-title: Associations between childhood cancer and ionizing radiation: results of a population‐based case‐control study in Germany publication-title: Cancer Epidemiology, Biomarkers and Prevention – volume: 330 start-page: 115 year: 1995 end-page: 181 article-title: Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks publication-title: Mutation Research – volume: 338 start-page: 1339 year: 1998 end-page: 1344 article-title: Risk of cancer among offspring of childhood‐cancer survivors. Association of the Nordic Cancer Registries and the Nordic Society of Paediatric Haematology and Oncology publication-title: New England Journal of Medicine – volume: 87 start-page: 51 year: 1996 end-page: 57 article-title: Influence of paternal (252) Cf neutron exposure on abnormal sperm, embryonal lethality, and liver tumorigenesis in the F(1) offspring of mice publication-title: Japanese Journal of Cancer Research – volume: 229 start-page: 115 year: 1990 end-page: 122 article-title: An examination of respiratory distress and chromosomal abnormalities in the offspring of male mice treated with ethylnitrosourea publication-title: Mutation Research – volume: 254 start-page: 609 year: 1985 end-page: 610 article-title: Vietnam veterans risk for fathering children with birth defects publication-title: Jama – volume: 229 start-page: 123 year: 1990 end-page: 128 article-title: Genotoxic potency in mouse spermatogonial stem cells of triethylenemelamine, mitomycin C, ethylnitrosourea, procarbazine, and propyl methanesulfonate as measured by F1 congenital defects publication-title: Mutation Research – volume: 423 start-page: 103 year: 1999 end-page: 111 article-title: Sperm chromatin damage associated with male smoking publication-title: Mutation Research – volume: 125 start-page: 75 year: 1984 end-page: 85 article-title: Induction of congenital malformations in the offspring of male mice treated with X‐rays at pre‐meiotic and post‐meiotic stages publication-title: Mutation Research – volume: 62 start-page: 45 year: 1998 end-page: 52 article-title: Genetic disease in offspring of long‐term survivors of childhood and adolescent cancer publication-title: American Journal of Human Genetics – volume: 68 start-page: 177 year: 1995 end-page: 183 article-title: Dose‐response of a radiation induction of a germline mutation at a hypervariable mouse minisatellite locus publication-title: International Journal of Radiation Biology – volume: 28 start-page: 475 year: 1981 end-page: 478 article-title: Increased cancer incidence in the progeny of male rats exposed to ethylnitrosourea before mating publication-title: International Journal of Cancer – volume: 21 start-page: 49 year: 1986 end-page: 64 article-title: Paternal contributions to birth defects publication-title: Nursing Clinics of North America – volume: 71 start-page: 3392 year: 1993 end-page: 3399 article-title: Fertility and pregnancy after treatment for cancer during childhood or adolescence publication-title: Cancer – volume: 16 start-page: 301 year: 1996 end-page: 305 article-title: Male‐mediated teratogenesis: spectrum of congenital malformations in the offspring of A/J male mice treated with ethylnitrosourea publication-title: Teratogenesis, Carcinogenesis, and Mutagenesis – volume: 316 start-page: 144 year: 1985 end-page: 146 article-title: Paternal cyclophosphamide treatment of rats causes fetal loss and malformations without affecting male fertility publication-title: Nature – volume: 422 start-page: 3 year: 1997 end-page: 7 article-title: The testis: the witness of the mating system, the site of mutation and the engine of desire publication-title: Acta Paediatrica Supplement – volume: 20 start-page: 325 year: 1999 end-page: 332 article-title: Possible carcinogenic effects of X‐rays in a transgenerational study with CBA mice publication-title: Carcinogenesis – volume: 20 start-page: 222 year: 1997 end-page: 228 article-title: Apoptosis as a mechanism of germ cell loss in elderly men publication-title: International Journal of Andrology – volume: 21 start-page: 122 year: 1993 end-page: 129 article-title: How much do we know about spontaneous human mutation rates? publication-title: Environmental and Molecular Mutagenesis – volume: 18 start-page: 611 year: 1996 end-page: 616 article-title: Review of experimental male‐mediated behavioral and neurochemical disorders publication-title: Neurotoxicology and Teratology – volume: 51 start-page: 261 year: 1990 end-page: 268 article-title: Reappraisal of the findings on Agent Orange by the Australian Royal Commission publication-title: Toxicology Letters – volume: 19 start-page: 105 year: 1999 end-page: 108 article-title: Commentary: paternal legacies publication-title: Teratogenesis, Carcinogenesis, and Mutagenesis – volume: 56 start-page: 1490 year: 1997 end-page: 1497 article-title: Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophosphamide publication-title: Biology of Reproduction – volume: 19 start-page: 87 year: 1999 end-page: 103 article-title: An investigation of male‐mediated F1 effects in mice treated acutely and sub‐chronically with urethane publication-title: Teratogenesis, Carcinogenesis, and Mutagenesis – volume: 353 start-page: 206 year: 1999 end-page: 207 article-title: Sex ratio after exposure to dioxin‐like chemicals in Taiwan publication-title: Lancet – volume: 1 start-page: 31 year: 1981 end-page: 39 article-title: Agent Orange toxicity: a quantitative perspective publication-title: Human Toxicology – volume: 70 start-page: 715 year: 1998 end-page: 723 article-title: Smoking cigarettes is associated with increased sperm disomy in teenage men publication-title: Fertility and Sterility – volume: 300 start-page: 423 year: 1990 end-page: 429 article-title: Results of case‐control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria publication-title: British Medical Journal – volume: 5 start-page: 125 year: 1999 end-page: 131 article-title: Detection of benzo[a]pyrene diol epoxide‐DNA adducts in embryos from smoking couples: evidence for transmission by spermatozoa publication-title: Molecular Human Reproduction – ident: e_1_2_8_113_2 doi: 10.1006/taap.1999.8692 – ident: e_1_2_8_40_2 doi: 10.1016/0027-5107(90)90097-N – ident: e_1_2_8_97_2 doi: 10.1097/00062752-199704040-00002 – ident: e_1_2_8_88_2 doi: 10.1016/S0015-0282(98)00261-1 – ident: e_1_2_8_37_2 doi: 10.1001/jama.1984.03350070021017 – ident: e_1_2_8_69_2 doi: 10.1016/S0027-5107(99)00028-7 – ident: e_1_2_8_21_2 doi: 10.1016/S0027-5107(97)00322-9 – ident: e_1_2_8_111_2 doi: 10.1111/j.1349-7006.1996.tb00199.x – ident: e_1_2_8_47_2 doi: 10.5694/j.1326-5377.1986.tb113816.x – ident: e_1_2_8_98_2 doi: 10.1038/bjc.1997.22 – ident: e_1_2_8_112_2 doi: 10.1016/0890-6238(93)90064-E – ident: e_1_2_8_20_2 doi: 10.1095/biolreprod56.6.1490 – ident: e_1_2_8_91_2 doi: 10.1002/j.1939-4640.1992.tb01630.x – volume: 10 start-page: 497 year: 1998 ident: e_1_2_8_9_2 article-title: Effect of aging on spontaneous and induced mouse testicular germ cell apoptosis publication-title: Aging (Milano) contributor: fullname: Barnes C. J. – volume: 12 start-page: 121 year: 1995 ident: e_1_2_8_26_2 article-title: Spontaneous mutation as a risk factor publication-title: Experimental and Clinical Immunogenetics contributor: fullname: Crow J. F. – ident: e_1_2_8_4_2 doi: 10.1016/S0027-5107(97)00197-8 – ident: e_1_2_8_14_2 doi: 10.1016/S0027-5107(99)00189-X – ident: e_1_2_8_60_2 doi: 10.1080/15287398109530119 – ident: e_1_2_8_58_2 doi: 10.1016/0027-5107(90)90089-M – ident: e_1_2_8_22_2 doi: 10.1080/09553009514550721 – ident: e_1_2_8_29_2 doi: 10.1038/367678a0 – ident: e_1_2_8_78_2 doi: 10.1016/0027-5107(88)90008-5 – ident: e_1_2_8_15_2 doi: 10.1046/j.1365-2605.1997.00056.x – ident: e_1_2_8_43_2 doi: 10.1086/301795 – volume: 259 start-page: 1668 year: 1988 ident: e_1_2_8_65_2 article-title: Birth defects in the Seveso area after TCDD contamination publication-title: Jama doi: 10.1001/jama.1988.03720110030030 contributor: fullname: Mastroiacovo P. – ident: e_1_2_8_89_2 doi: 10.1080/09553009414550641 – ident: e_1_2_8_13_2 doi: 10.1016/S0027-5107(97)00196-6 – ident: e_1_2_8_31_2 doi: 10.1038/ng0993-92 – volume: 83 start-page: 152 year: 1998 ident: e_1_2_8_50_2 article-title: Spontaneous germ cell apoptosis in humans: evidence for ethnic differences in the susceptibility of germ cells to programmed cell death publication-title: Journal of Clinical Endocrinology and Metabolism doi: 10.1210/jcem.83.1.4485 contributor: fullname: Hikim A. P. – ident: e_1_2_8_100_2 doi: 10.1016/0378-4274(90)90068-W – volume: 21 start-page: 49 year: 1986 ident: e_1_2_8_24_2 article-title: Paternal contributions to birth defects publication-title: Nursing Clinics of North America doi: 10.1016/S0029-6465(22)00345-0 contributor: fullname: Cohen F. L. – ident: e_1_2_8_84_2 doi: 10.1095/biolreprod53.6.1465 – ident: e_1_2_8_104_2 doi: 10.1016/0027-5107(90)90096-M – ident: e_1_2_8_41_2 doi: 10.1002/tera.1420290208 – ident: e_1_2_8_57_2 doi: 10.1093/jnci/89.3.238 – ident: e_1_2_8_2_2 doi: 10.1016/0027-5107(95)00039-L – ident: e_1_2_8_34_2 doi: 10.1080/095530098140952 – ident: e_1_2_8_82_2 doi: 10.1016/S0027-5107(97)00199-1 – ident: e_1_2_8_28_2 doi: 10.1136/bmj.307.6897.164 – ident: e_1_2_8_105_2 doi: 10.1038/316144a0 – ident: e_1_2_8_96_2 doi: 10.1111/j.1651-2227.1997.tb18336.x – ident: e_1_2_8_33_2 doi: 10.1073/pnas.95.11.6251 – ident: e_1_2_8_76_2 doi: 10.1038/296575a0 – ident: e_1_2_8_80_2 doi: 10.1016/0027-5107(90)90085-I – ident: e_1_2_8_23_2 doi: 10.1007/BF01973499 – ident: e_1_2_8_106_2 doi: 10.1095/biolreprod34.2.275 – ident: e_1_2_8_94_2 doi: 10.1016/0027-5107(84)90144-1 – ident: e_1_2_8_61_2 doi: 10.1016/0165-1161(94)90044-2 – ident: e_1_2_8_42_2 doi: 10.1136/bmj.300.6722.423 – ident: e_1_2_8_55_2 doi: 10.1016/0027-5107(90)90091-H – ident: e_1_2_8_53_2 doi: 10.1016/S0140-6736(05)70586-9 – ident: e_1_2_8_64_2 doi: 10.1093/mutage/12.3.147 – ident: e_1_2_8_86_2 doi: 10.1002/(SICI)1098-2280(1997)30:2<175::AID-EM10>3.0.CO;2-A – volume: 59 start-page: 431 year: 1996 ident: e_1_2_8_10_2 article-title: Complete paternal isodisomy for chromosome 8 unmasked by lipoprotein lipase deficiency publication-title: American Journal of Human Genetics contributor: fullname: Benlian P. – ident: e_1_2_8_77_2 doi: 10.1016/0165-7992(83)90087-8 – ident: e_1_2_8_81_2 doi: 10.2307/3577440 – ident: e_1_2_8_39_2 doi: 10.1016/0027-5107(95)00251-0 – ident: e_1_2_8_38_2 doi: 10.1080/09553009514551081 – ident: e_1_2_8_8_2 doi: 10.1095/biolreprod50.1.55 – ident: e_1_2_8_90_2 doi: 10.1056/NEJM199805073381902 – volume: 28 start-page: 139 year: 1980 ident: e_1_2_8_11_2 article-title: Experiences from the accident of Seveso publication-title: Acta Morphologica Academiae Scientiarum Hungaricae contributor: fullname: Bisanti L. – ident: e_1_2_8_16_2 doi: 10.1530/jrf.0.1050025 – ident: e_1_2_8_70_2 doi: 10.1016/0027-5107(88)90159-5 – volume: 54 start-page: 482 year: 1994 ident: e_1_2_8_18_2 article-title: Paternal isodisomy for chromosome 5 in a child with spinal muscular atrophy publication-title: American Journal of Human Genetics contributor: fullname: Brzustowicz L. M. – ident: e_1_2_8_93_2 doi: 10.1016/0027-5107(73)90022-5 – ident: e_1_2_8_114_2 doi: 10.1093/molehr/5.2.125 – ident: e_1_2_8_27_2 doi: 10.1073/pnas.94.16.8380 – ident: e_1_2_8_25_2 doi: 10.1002/em.2850210205 – ident: e_1_2_8_108_2 doi: 10.1111/j.1365-2605.1996.tb00523.x – volume: 8 start-page: 793 year: 1999 ident: e_1_2_8_66_2 article-title: Associations between childhood cancer and ionizing radiation: results of a population‐based case‐control study in Germany publication-title: Cancer Epidemiology, Biomarkers and Prevention contributor: fullname: Meinert R. – ident: e_1_2_8_110_2 doi: 10.1093/carcin/9.11.1931 – ident: e_1_2_8_7_2 doi: 10.1016/S1383-5718(99)00144-8 – ident: e_1_2_8_62_2 doi: 10.1080/095530098140998 – ident: e_1_2_8_73_2 doi: 10.1002/(SICI)1520-6866(1997)17:4/5<225::AID-TCM5>3.0.CO;2-K – ident: e_1_2_8_35_2 doi: 10.1002/(SICI)1520-6866(1999)19:2<87::AID-TCM2>3.0.CO;2-I – ident: e_1_2_8_74_2 doi: 10.1016/S0892-0362(96)00123-7 – ident: e_1_2_8_92_2 doi: 10.1016/0027-5107(73)90021-3 – ident: e_1_2_8_49_2 doi: 10.1038/bjc.1995.259 – ident: e_1_2_8_51_2 doi: 10.1016/S0890-6238(99)00011-8 – ident: e_1_2_8_3_2 doi: 10.1016/0300-483X(96)03436-1 – ident: e_1_2_8_45_2 doi: 10.1056/NEJM199107183250301 – ident: e_1_2_8_109_2 doi: 10.1016/0027-5107(93)90013-6 – ident: e_1_2_8_72_2 doi: 10.1002/(SICI)1520-6866(1996)16:6<301::AID-TCM2>3.0.CO;2-M – ident: e_1_2_8_83_2 doi: 10.1016/S0027-5107(98)00242-5 – ident: e_1_2_8_107_2 doi: 10.1095/biolreprod37.2.317 – ident: e_1_2_8_59_2 doi: 10.1016/0027-5107(84)90034-4 – volume: 41 start-page: 218 year: 1987 ident: e_1_2_8_85_2 article-title: Spontaneous mutation and parental age in humans publication-title: American Journal of Human Genetics contributor: fullname: Risch N. – ident: e_1_2_8_101_2 doi: 10.1001/jama.254.5.609 – ident: e_1_2_8_30_2 doi: 10.1136/bmj.315.7117.1181 – ident: e_1_2_8_99_2 doi: 10.1038/bjc.1997.589 – ident: e_1_2_8_54_2 doi: 10.1038/ng0294-136 – ident: e_1_2_8_67_2 doi: 10.1016/S0140-6736(05)65030-1 – ident: e_1_2_8_46_2 doi: 10.1002/tera.1420450612 – ident: e_1_2_8_32_2 doi: 10.1038/380683a0 – ident: e_1_2_8_71_2 doi: 10.1016/0027-5107(90)90086-J – ident: e_1_2_8_115_2 doi: 10.1093/ije/21.2.273 – volume: 5 start-page: 1175 year: 1998 ident: e_1_2_8_95_2 article-title: Tumorigenesis in F1 offspring mice following paternal 12.5 cGy 252Cf fission neutron irradiation publication-title: Oncology Reports contributor: fullname: Shoji S. – ident: e_1_2_8_48_2 doi: 10.1016/S0378-4274(98)00312-9 – ident: e_1_2_8_103_2 doi: 10.1002/ijc.2910280413 – volume: 59 start-page: 40 year: 1996 ident: e_1_2_8_12_2 article-title: The late effects of the toxic action of platinum‐containing cytostatic preparations on rat progeny publication-title: Eksperimentalnaia I Klinicheskaia Farmakologiia contributor: fullname: Borovskaia T. G. – ident: e_1_2_8_44_2 doi: 10.1038/255077a0 – ident: e_1_2_8_87_2 doi: 10.1016/S0140-6736(05)77215-9 – volume: 96 start-page: 207 year: 1989 ident: e_1_2_8_36_2 article-title: Germ Cell Mutations in Mice publication-title: IARC Scientific Publications contributor: fullname: Ehling U. H. – ident: e_1_2_8_52_2 doi: 10.1097/00001648-199911000-00016 – ident: e_1_2_8_79_2 doi: 10.1269/jrr.32.SUPPLEMENT2_64 – ident: e_1_2_8_63_2 doi: 10.1038/bjc.1998.491 – ident: e_1_2_8_75_2 doi: 10.1002/1097-0142(19930515)71:10 <3392::AID-CNCR2820711743>3.0.CO;2-F – ident: e_1_2_8_17_2 doi: 10.1002/(SICI)1097-0142(19990315)85:6<1380::AID-CNCR23>3.0.CO;2-O – ident: e_1_2_8_19_2 doi: 10.1086/301677 – ident: e_1_2_8_5_2 doi: 10.1002/(SICI)1520-6866(1999)19:2<105::AID-TCM3>3.0.CO;2-K – ident: e_1_2_8_102_2 doi: 10.1177/096032718100100104 – ident: e_1_2_8_68_2 doi: 10.1093/carcin/20.2.325 – ident: e_1_2_8_6_2 doi: 10.1007/978-1-4615-1877-8_12 – ident: e_1_2_8_56_2 doi: 10.1016/0165-1218(87)90115-7 |
| SSID | ssj0003831 |
| Score | 1.7886455 |
| SecondaryResourceType | review_article |
| Snippet | The concept that mutations can be induced in the male germ‐line and result in adverse effects in the offspring has achieved only limited acceptance despite... The concept that mutations can be induced in the male germ-line and result in adverse effects in the offspring has achieved only limited acceptance despite... |
| SourceID | crossref pubmed wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 123 |
| SubjectTerms | Animals apoptosis Female genomic instability Germ-Line Mutation Humans Male male germ-line mutation male-mediated teratogenesis Mutagens - toxicity Paternity |
| Title | Paternal transmission of genetic damage: findings in animals and humans |
| URI | https://api.istex.fr/ark:/67375/WNG-2NLF94D8-M/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1046%2Fj.1365-2605.2000.00222.x https://www.ncbi.nlm.nih.gov/pubmed/10844537 |
| Volume | 23 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1JSyNBFH6IgszFcRvNuFAH8dah0lW9ZG7RGBdMEFHGW1Nbi4S0ohEcf73vVbUxiodBPHXTdFV3bW9_3wPYKZFr25InkVOxiGRueaR1nEZOWKENN7lSZNDvD9KjS3lylVzV8U-UCxPwISYGNzoZnl7TAVc6VCHhHt12EqHFE59v0vR5nU2SJ1sio-i-7vkbkhQqYqE0If4WAbDUQT21g_PTjt5xqjma9KcpNjUtynpe1PsJw9dRhBCUYfNxrJvm-QPA4_cMcxEWapGVdcIeW4IZVy3DSqdCdX30j-0yH0TqrfPLMN-vffUrcHimAsA0GxM_xP1Ehjl2WzLcs5Q6yawaITX7w7zfvLp-YDcVU9XNCE8EXi3z9QMfVuGyd3CxfxTVZRsiI7mIo9gSAU3auUFdC9UZRTKaUlwhPbNZqZRwtkQ1qyWcQWnSpvgyPk-s0cYiBRG_YLa6rdw6MNe2qSupMqnjUkulExRnuZImb8elzGwDWq9LVNwFdI7Ce9UlZaDRxBU0cVRrk1BQceKKpwbs-rWcNFD3Q4puy5Li7-CwiAenvbbs5kW_AWthsae6zqVMRNaA1C_Zf3-zOD7pDPDu91cbbsCPgAFA5p9NmB3fP7otlIbGehvmOnvdvd623-8v3W_57Q |
| link.rule.ids | 314,780,784,1375,27924,27925,46294,46718 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrR1NS8Mw9CEK6sXvj_mZg3jr7Nq067wNdU7dioiit5AmqQxdFZ2g_nrfS6pO8SDiqaU0afOS9_0FsJUj19a5H3lGBqHHE-17WRbEngl1mClfJVKSQb-bxu0LfnwVXZXtgCgXxtWH-DC4EWZYek0ITgbpndIt6bDchWj5kU04qdrEzioKlGOI_TWK79o_-6wlhaqYa06IP0YlWMqwntLF-eNMX3jVGIH9eYhRDQuzlhu1puH2fR0uCOWm-jTIqur1W4nHf1roDEyVUitrumM2CyOmmIP5ZoEae_-FbTMbR2oN9HMw3i3d9fNweCpdjWk2IJaIR4psc-wuZ3hsKXuSadlHgrbLrOu8uH5kvYLJotdHpMCrZraF4OMCXLQOzvfaXtm5wVPcDwMv0ERDo0aiUN1CjUaSmCalL5Gk6XouZWh0jppWLTQKBUod48v4PNIqUxqJSLgIo8VdYZaBmYaOTU7NSY3PMy6zCCVaX3KVNIKc13UFau97JO5dgQ5hHeucktAIcIIAR-02qRAqAk48V2DbbubHAPlwQwFu9UhcpociSDutBt9PRLcCS263h6ZOOI_CegViu2e__qY4Om6meLfy14GbMNE-73ZE5yg9WYVJVxKArEFrMDp4eDLrKBwNsg176N8Ay9D8nA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1JS8NAFH6IBfHivtR1DuItNSaTNPFWrHVtEFH0NkxmJiKlUbSC-ut9bybVKh5EPCWEzCSzvf19D2CrQK6tCz_yjAxCjyfa9_I8iD0T6jBXvkqkJIN-N4uPrvjJTXRTxT9RLozDh_gwuNHJsPSaDviDLnYqr6Q75C5Cy49svknD5nU2UJ6s8ThICUe_ffEJJYWamKtNiP9FCCxVVE_l4fyxpy-sqkaz_jLCp0ZlWcuMOtPQGw7DxaD0Gs-DvKHeviE8_s84Z2CqkllZy22yWRgz5RzMt0rU1_uvbJvZKFJrnp-DiW7lrJ-Hw3PpEKbZgBgibiiyzLH7guGmpdxJpmUfydkes47z8vaJ3ZVMlnd9PBJ41cwWEHxagKvOweX-kVfVbfAU98PACzRR0ChNFCpbqM9IEtKk9CUSNN0spAyNLlDP2g2NQnFSx_gyPo-0ypVGEhIuwnh5X5plYCbVsSmoNKnxec5lHqE860uukjQoeFPXYXe4ROLBwXMI61bnlIJGEydo4qjYJsGg4sSJlzps27X8aCAfexTe1ozEdXYoguysk_J2Irp1WHKLPdJ1wnkUNusQ2yX79TfF8Ukrw7uVvzbchInzdkecHWenqzDp8ADIFLQG44PHZ7OOktEg37Bb_h3BDvtL |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Paternal+transmission+of+genetic+damage%3A+findings+in+animals+and+humans&rft.jtitle=International+journal+of+andrology&rft.au=Brinkworth%2C+M+H&rft.date=2000-06-01&rft.issn=0105-6263&rft.volume=23&rft.issue=3&rft.spage=123&rft_id=info:doi/10.1046%2Fj.1365-2605.2000.00222.x&rft_id=info%3Apmid%2F10844537&rft.externalDocID=10844537 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0105-6263&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0105-6263&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0105-6263&client=summon |