Pediatric tolerogenic DCs expressing CD4 and immunoglobulin‐like transcript receptor (ILT)‐4 secrete IL‐10 in response to Fc and adenosine

• Published in: European journal of immunology Vol. 48; no. 3; pp. 482 - 491
• Main Authors: Franco, Alessandra, Kumar, Jeetendra, Lin, Gene, Behnamfar, Negar, Hsieh, Li‐En, Shimizu, Chisato, Tremoulet, Adriana H., Burns, Jane C., Linden, Joel
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.03.2018
• Subjects: Adenosine; Antigen-presenting cells; CD11b; CD11b antigen; CD11c; CD11c antigen; CD14; CD14 antigen; CD4 antigen; Cell culture; Children; Constant region; Cyclic AMP; Cytokines; Dendritic cells; Immunoglobulins; Immunoregulation; Immunosuppression; Infants; Inflammation; Kawasaki disease; Lymphocytes; Lymphocytes T; Neoantigens; Pediatrics; Phenotypes; Transcription; T cells; Kawasaki disease; CD14; T cells; CD11c; CD11b

We characterized a novel population of tolerogenic myeloid dendritic cells (tmDCs) defined as CD11c+CD11b+CD14+CD4+ and immunoglobulin‐like transcript receptor (ILT)‐4+ that are significantly more abundant in the circulation of infants and young children than in adults. TmDCs secrete the immunosuppr...