Pulsatile Basal Insulin Secretion Is Driven by Glycolytic Oscillations

In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well studied at high glucose levels, comparatively little is known about its origin under basal conditions. We propose a possible mechanism for basal insulin oscillations based on oscillations in glycolysis, dem...

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Bibliographic Details
Published inPhysiology (Bethesda, Md.) Vol. 37; no. 4
Main Authors Fletcher, P A, Marinelli, I, Bertram, R, Satin, L S, Sherman, A S
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.07.2022
Subjects
Calcium - metabolism
Glucose - metabolism
Glycolysis
Humans
Insulin - metabolism
Insulin Secretion
Islets of Langerhans - metabolism
Review
metabolism
calcium
bursting electrical activity
pulsatile insulin secretion
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Summary:In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well studied at high glucose levels, comparatively little is known about its origin under basal conditions. We propose a possible mechanism for basal insulin oscillations based on oscillations in glycolysis, demonstrated using an established mathematical model. At high glucose, this is superseded by a calcium-dependent mechanism.
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ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00044.2021