Pulsatile Basal Insulin Secretion Is Driven by Glycolytic Oscillations
In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well studied at high glucose levels, comparatively little is known about its origin under basal conditions. We propose a possible mechanism for basal insulin oscillations based on oscillations in glycolysis, dem...
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Published in | Physiology (Bethesda, Md.) Vol. 37; no. 4 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Physiological Society
01.07.2022
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Subjects | |
Online Access | Get full text |
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Summary: | In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well studied at high glucose levels, comparatively little is known about its origin under basal conditions. We propose a possible mechanism for basal insulin oscillations based on oscillations in glycolysis, demonstrated using an established mathematical model. At high glucose, this is superseded by a calcium-dependent mechanism. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 |
ISSN: | 1548-9213 1548-9221 |
DOI: | 10.1152/physiol.00044.2021 |