Dose–response relationships of rabeprazole 5, 10, 20, and 40 mg once daily on suppression of gastric acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes

• Published in: European journal of clinical pharmacology Vol. 68; no. 5; pp. 579 - 588
• Main Authors: Hayato, Seiichi, Hasegawa, Setsuo, Hojo, Seiichiro, Okawa, Hiroki, Abe, Hiroaki, Sugisaki, Nobuyuki, Munesue, Masahiro, Horai, Yukio, Ohnishi, Akihiro
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.05.2012; Springer; Springer Nature B.V
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage; 2-Pyridinylmethylsulfinylbenzimidazoles - adverse effects; 2-Pyridinylmethylsulfinylbenzimidazoles - blood; 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology; Adult; Anti-Ulcer Agents - administration & dosage; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Circadian Rhythm; Cross-Over Studies; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Double-Blind Method; Gastric Acid - metabolism; Gastric Mucosa - drug effects; Gastric Mucosa - metabolism; Genotype; Half-Life; Humans; Japan; Male; Medical sciences; Models, Biological; Pharmacodynamics; Pharmacology. Drug treatments; Pharmacology/Toxicology; Polymorphism, Genetic; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - adverse effects; Proton Pump Inhibitors - blood; Proton Pump Inhibitors - pharmacology; Rabeprazole; Young Adult; Asia; Japan; CYP2C19 genotype; GERD; Pharmacodynamics; Nocturnal gastric pH; Rabeprazole; Pharmacokinetics; Night; Isozyme; H; Antiulcer agent; K; Proton pump inhibitor; Dose activity relation; pH; Single daily dose; Human; Stomach; Healthy subject; Digestive system; Enzyme; Secretion; Cytochrome P450; Enzyme inhibitor; Genotype; CYP2C 19 genotype; Biological activity; Acids; Benzimidazole derivatives; exchanging ATPase; Hydrolases; Daily dose

Purpose This study was designed to investigate the antisecretory activity of rabeprazole administered once daily in doses of 5, 10, 20, and 40 mg and different cytochrome P450 2C19 (CYP2C19) genotypes on gastric pH in healthy individuals. Additional objectives were delineating the nighttime from the...