Eucaryotic DNA Replication Complex: Study of Structure and Function Using the Affinity Modification Technique

• Published in: Biochemistry (Moscow) Vol. 69; no. 3; pp. 248 - 261
• Main Authors: Khlimankov, D. Yu, Rechkunova, N. I., Lavrik, O. I.
• Format: Journal Article
• Language: English
• Published: United States Springer 01.03.2004; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biopolymers; Deoxyribonucleic acid; DNA; DNA replication; DNA Replication - physiology; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - metabolism; DNA-Directed DNA Polymerase - chemistry; DNA-Directed DNA Polymerase - metabolism; Eukaryotic Cells - enzymology; Flap Endonucleases - chemistry; Flap Endonucleases - metabolism; Humans; Metallurgy; Molecular biology; Nucleic acids; Proliferating Cell Nuclear Antigen - chemistry; Proliferating Cell Nuclear Antigen - metabolism; Protein Binding; Protein Structure, Tertiary; Protein Subunits - chemistry; Protein Subunits - metabolism; Proteins; Structure-Activity Relationship; Substrate Specificity; X-Ray Diffraction

Eucaryotic DNA replication complex is now one of the most intensively studied subjects of molecular biology and biochemistry. In addition to detailed studies on the structures and functions of individual DNA polymerases involved in this process, other enzymes and protein factors are also given much...