Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 123; no. 6; p. 1804
• Main Authors: Suraweera, Nirosha, Duval, Alex, Reperant, Maryline, Vaury, Christelle, Furlan, Daniela, Leroy, Karen, Seruca, Raquel, Iacopetta, Barry, Hamelin, Richard
• Format: Journal Article
• Language: English
• Published: United States 01.12.2002
• Subjects: Africa - ethnology; African Continental Ancestry Group - genetics; Cell Line; DNA, Neoplasm - genetics; Endometrial Neoplasms - genetics; European Continental Ancestry Group - genetics; Female; Fluorescence; Gastrointestinal Neoplasms - genetics; Humans; Microsatellite Repeats; Paris - ethnology; Polymerase Chain Reaction - methods; Paris; Africa

The microsatellite instability (MSI) phenotype is a characteristic of the hereditary nonpolyposis colorectal cancer syndrome as well as approximately 15% of sporadic colon and gastric tumors. It is a valuable diagnostic marker for the identification of hereditary nonpolyposis colorectal cancer cases...