Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling

• Published in: Clinical pharmacokinetics Vol. 52; no. 12; pp. 1085 - 1100
• Main Authors: Barter, Zoe E., Tucker, Geoffrey T., Rowland-Yeo, Karen
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2013; Adis International; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; European Continental Ancestry Group - genetics; Female; General pharmacology; Humans; Internal Medicine; Kidney - physiology; Liver - anatomy & histology; Liver - blood supply; Liver - metabolism; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Models, Biological; Organ Size; Original Research Article; Pharmacokinetics; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacotherapy; Regional Blood Flow; Young Adult; Asia; China; Omeprazole; Bupropion; Midazolam; Desipramine; Tolbutamide; Human; Enzyme; Cytochrome P450; Chinese; Caucasoid; Predictive factor; Pharmacokinetics; Modeling; Ethnic group

Background International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines emphasize the need for better understanding of the influence of ethnicity on drug response to minimize duplication of clinical studies, thereby expediting...