Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling - Barter, Zoe E.; Tucker, Geoffrey T.; Rowland-Yeo, Karen (Clinical pharmacokinetics, 2013)
Keywords: Adolescent; Adult; Aged; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; European Continental Ancestry Group - genetics; Female; General pharmacology; Humans; Internal Medicine; Kidney - physiology; Liver - anatomy & histology; Liver - blood supply; Liver - metabolism; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Models, Biological; Organ Size; Original Research Article; Pharmacokinetics; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacotherapy; Regional Blood Flow; Young Adult; Asia; China; Omeprazole; Bupropion; Midazolam; Desipramine; Tolbutamide; Human; Enzyme; Cytochrome P450; Chinese; Caucasoid; Predictive factor; Pharmacokinetics; Modeling; Ethnic group