Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 52; pp. E12435 - E12442
• Main Authors: Vera-Chang, Marilyn N., St-Jacques, Antony D., Gagné, Rémi, Martyniuk, Chris J., Yauk, Carole L., Moon, Thomas W., Trudeau, Vance L.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 26.12.2018
• Series: PNAS Plus
• Subjects: Adrenocorticotropic hormone; Adults; Animals; Antidepressants; Antidepressive Agents - pharmacology; Behavior, Animal - drug effects; Biological Sciences; Danio rerio; Depressive Disorder; Developmental stages; Disruption; Epigenetics; Exposure; Family Characteristics; Female; Fetuses; Fluoxetine; Fluoxetine - adverse effects; Fluoxetine - pharmacology; Human exposure; Hydrocortisone - metabolism; Male; Males; Maternal Exposure - adverse effects; Maternal-Fetal Exchange - drug effects; Mental depression; Placenta; PNAS Plus; Postpartum depression; Pregnancy; Serotonin; Serotonin uptake inhibitors; Serotonin Uptake Inhibitors - pharmacology; Side effects; Stress, Psychological; Zebrafish; Zebrafish - metabolism; Zebrafish - physiology; Zebrafish Proteins - metabolism; stress; fluoxetine; zebrafish; epigenetic; transgenerational

The global prevalence of depression is high during childbearing. Due to the associated risks to the mother and baby, the selective serotonin reuptake inhibitor fluoxetine (FLX) is often the first line of treatment. Given that FLX readily crosses the placenta, a fetus may be susceptible to the disrup...