Are all mismatch repair deficient endometrial cancers created equal? A large, retrospective, tertiary center experience

• Published in: European journal of cancer (1990) Vol. 220; p. 115344
• Main Authors: Capasso, Ilaria, Perrone, Emanuele, Duranti, Simona, Giannarelli, Diana, Nero, Camilla, Cordisco, Emanuela Lucci, Pomponi, Maria Grazia, Remondini, Laura, Piermattei, Alessia, Valente, Michele, Santoro, Angela, Esposito, Giovanni, Parisi, Giuseppe, Giuliano, Maria Consiglia, Corrado, Martina, Scambia, Giovanni, Fanfani, Francesco
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 02.05.2025
• Subjects: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Colorectal Neoplasms; DNA Methylation; DNA Mismatch Repair - genetics; Endometrial cancer; Endometrial Neoplasms - genetics; Endometrial Neoplasms - mortality; Endometrial Neoplasms - pathology; Female; Humans; Immunohistochemistry; Methylation; Middle Aged; Mismatch repair deficiency; Molecular classification; MutL Protein Homolog 1 - genetics; Neoplastic Syndromes, Hereditary; Prognosis; Retrospective Studies; Survival; Tertiary Care Centers; Immunohistochemistry; Molecular classification; Mismatch repair deficiency; Endometrial cancer; Methylation; Survival

One third of endometrial carcinomas (ECs) presents with mismatch repair deficiency (MMRd). Of these, 70 % are caused by somatic hypermethylation of MLH1 promoter; the remaining cases are determined by Lynch syndrome or double somatic inactivation of MMR genes. Although associated with good-intermedi...