Enterovirus D68 infection induces IL-17-dependent neutrophilic airway inflammation and hyperresponsiveness

• Published in: JCI insight Vol. 3; no. 16
• Main Authors: Rajput, Charu, Han, Mingyuan, Bentley, J Kelley, Lei, Jing, Ishikawa, Tomoko, Wu, Qian, Hinde, Joanna L, Callear, Amy P, Stillwell, Terri L, Jackson, William T, Martin, Emily T, Hershenson, Marc B
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 23.08.2018
• Subjects: Allergens - administration & dosage; Allergens - immunology; Animals; Asthma - immunology; Asthma - pathology; Asthma - virology; Bronchoalveolar Lavage Fluid - cytology; Bronchoalveolar Lavage Fluid - immunology; Cell Line, Tumor; Child; Child, Preschool; Disease Models, Animal; Enterovirus - immunology; Enterovirus - isolation & purification; Enterovirus D, Human - immunology; Enterovirus D, Human - isolation & purification; Enterovirus Infections - immunology; Enterovirus Infections - pathology; Enterovirus Infections - virology; Female; Humans; Infant; Infant, Newborn; Interleukin-17 - antagonists & inhibitors; Interleukin-17 - genetics; Interleukin-17 - immunology; Interleukin-17 - metabolism; Lung - cytology; Lung - pathology; Male; Mice; Nasopharynx - immunology; Nasopharynx - pathology; Nasopharynx - virology; Neutrophils - drug effects; Neutrophils - immunology; Neutrophils - metabolism; Pyroglyphidae - immunology; RNA, Messenger - metabolism; Pulmonology; Allergy; Infectious disease; Cytokines; Asthma

Enterovirus D68 (EV-D68) shares biologic features with rhinovirus (RV). In 2014, a nationwide outbreak of EV-D68 was associated with severe asthma-like symptoms. We sought to develop a mouse model of EV-D68 infection and determine the mechanisms underlying airway disease. BALB/c mice were inoculated...