Expression of Class III Beta-Tubulin Is Associated with Invasive Potential and Poor Prognosis in Thyroid Carcinoma

Although American Thyroid Association guidelines offer a risk stratification scheme for thyroid cancer patients, there is a continuous need for more sophisticated biomarkers that can predict disease progression. In this study, we aim to evaluate the prognostic value of class III beta-tubulin (TUBB3)...

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Published inJournal of clinical medicine Vol. 9; no. 12; p. 3830
Main Authors Na, Hee Young, Park, Mira, Kim, Young A, Won, Jae Kyung, Park, Young Joo, Shin, Sun Ah, Lee, Sejoon, Oh, Sohee, Kim, Ji Eun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.11.2020
MDPI
Subjects
Antibodies
Chemotherapy
class III beta-tubulin
Clinical medicine
epithelial–mesenchymal transition
Genomics
invasion
Lymphatic system
Medical prognosis
Medical research
Metastasis
prognosis
Thyroid cancer
thyroid carcinoma
Tumors
United Kingdom > UK
United States > US
Germany
epithelial–mesenchymal transition
thyroid carcinoma
invasion
class III beta-tubulin
prognosis
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Abstract Although American Thyroid Association guidelines offer a risk stratification scheme for thyroid cancer patients, there is a continuous need for more sophisticated biomarkers that can predict disease progression. In this study, we aim to evaluate the prognostic value of class III beta-tubulin (TUBB3) and uncover the relationship between TUBB3 and invasive potential in thyroid carcinoma. Immunohistochemistry (IHC) for TUBB3 and E-cadherin was performed on a total of 254 cases of thyroid cancer specimens. Tumor budding at the invasive margin was evaluated. In vitro functional studies were also performed; the protein and mRNA levels of TUBB3 were compared among the five cell types at baseline, with transwell invasion and after blocking of TUBB3 by shRNA. IHC revealed that the levels of TUBB3 were higher in conventional papillary carcinomas (cPTCs) and anaplastic thyroid carcinomas (ATCs). In univariate analysis, high tumor budding and TUBB3 expression were associated with inferior progression-free survival in cPTC. The results of a Western blot and RT-PCR agreed with the IHC finding. The results were further validated through data from The Cancer Genome Atlas database. Our results suggest that high expression of TUBB3 in thyroid carcinoma could predict invasive potential and possibly be linked with epithelial-mesenchymal transition.
AbstractList Although American Thyroid Association guidelines offer a risk stratification scheme for thyroid cancer patients, there is a continuous need for more sophisticated biomarkers that can predict disease progression. In this study, we aim to evaluate the prognostic value of class III beta-tubulin (TUBB3) and uncover the relationship between TUBB3 and invasive potential in thyroid carcinoma. Immunohistochemistry (IHC) for TUBB3 and E-cadherin was performed on a total of 254 cases of thyroid cancer specimens. Tumor budding at the invasive margin was evaluated. In vitro functional studies were also performed; the protein and mRNA levels of TUBB3 were compared among the five cell types at baseline, with transwell invasion and after blocking of TUBB3 by shRNA. IHC revealed that the levels of TUBB3 were higher in conventional papillary carcinomas (cPTCs) and anaplastic thyroid carcinomas (ATCs). In univariate analysis, high tumor budding and TUBB3 expression were associated with inferior progression-free survival in cPTC. The results of a Western blot and RT-PCR agreed with the IHC finding. The results were further validated through data from The Cancer Genome Atlas database. Our results suggest that high expression of TUBB3 in thyroid carcinoma could predict invasive potential and possibly be linked with epithelial-mesenchymal transition.
Author Na, Hee Young
Won, Jae Kyung
Shin, Sun Ah
Park, Young Joo
Oh, Sohee
Park, Mira
Kim, Young A
Lee, Sejoon
Kim, Ji Eun
AuthorAffiliation 4 Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea; yjparkmd@snu.ac.kr
5 Precision Medicine Center, Seoul National University Bundang Hospital, Seongnam 13620, Korea; sejoonlee@snubh.org
1 Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Korea; 0614nina@hanmail.net
2 Department of Pathology, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Korea; i01085790402@gmail.com (M.P.); pathgirl@daum.net (Y.A.K.)
3 Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea; jk_won@hanmail.net (J.K.W.); westps@hanmail.net (S.A.S.)
6 Department of Biostatistics, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Seoul 07061, Korea; oh.sohee@gmail.com
AuthorAffiliation_xml – name: 1 Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Korea; 0614nina@hanmail.net
– name: 2 Department of Pathology, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Korea; i01085790402@gmail.com (M.P.); pathgirl@daum.net (Y.A.K.)
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Issue 12
Keywords epithelial–mesenchymal transition
thyroid carcinoma
invasion
class III beta-tubulin
prognosis
Language English
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Snippet Although American Thyroid Association guidelines offer a risk stratification scheme for thyroid cancer patients, there is a continuous need for more...
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SubjectTerms Antibodies
Chemotherapy
class III beta-tubulin
Clinical medicine
epithelial–mesenchymal transition
Genomics
invasion
Lymphatic system
Medical prognosis
Medical research
Metastasis
prognosis
Thyroid cancer
thyroid carcinoma
Tumors
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Title Expression of Class III Beta-Tubulin Is Associated with Invasive Potential and Poor Prognosis in Thyroid Carcinoma
URI https://www.ncbi.nlm.nih.gov/pubmed/33256003
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