Glutathione loading prevents free radical injury in red blood cells after storage

• Published in: Free radical research Vol. 33; no. 5; pp. 517 - 529
• Main Authors: Dumaswala, U.J., Wilson, M.J., Wu, Y.L., Wykle, J., Zhuo, L., Douglass, L.M., Daleke, D.L.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2000; Taylor & Francis
• Subjects: Biological Transport; Blood Banks; Catalase - metabolism; Erythrocyte Membrane - metabolism; Erythrocytes - metabolism; Free Radicals - metabolism; Glutathione - metabolism; Glutathione - pharmacology; Humans; In Vitro Techniques; Osmosis; Oxidative Stress; Phosphatidylserines - metabolism; Sulfhydryl Compounds - metabolism; Thromboplastin - metabolism

We have previously demonstrated that the loss of glutathione (GSH) and GSH-peroxidase (GSH-PX) in banked red blood cells (RBCs) is accompanied by oxidative modifications of lipids, proteins and loss of membrane integrity[1]. The objective of this study was to determine whether artificial increases i...