Clinical pharmacokinetics of Icotinib, an anti-cancer drug: evaluation of dose proportionality, food effect, and tolerability in healthy subjects - Liu, Dongyang; Jiang, Ji; Zhang, Li; Tan, Fenlai; Wang, Yingxiang; Zhang, Don; Hu, Pei (Cancer chemotherapy and pharmacology, 2014)
Keywords: Adult; Antineoplastic agents; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Antineoplastic Agents - blood; Antineoplastic Agents - pharmacokinetics; Biological and medical sciences; Cancer Research; Cross-Over Studies; Crown Ethers - administration & dosage; Crown Ethers - adverse effects; Crown Ethers - blood; Crown Ethers - pharmacokinetics; Dose-Response Relationship, Drug; Food-Drug Interactions; Humans; Male; Medical sciences; Medicine; Medicine & Public Health; Oncology; Original Article; Pharmacology. Drug treatments; Pharmacology/Toxicology; Quinazolines - administration & dosage; Quinazolines - adverse effects; Quinazolines - blood; Quinazolines - pharmacokinetics; Xenograft Model Antitumor Assays; Young Adult; Icotinib; Healthy subjects; Pharmacokinetics; Tyrosine kinase inhibitor; EGFR; Antineoplastic agent; Human; Drug; Evaluation; Healthy subject; Enzyme; Toxicity; Transferases; Enzyme inhibitor; Epidermal growth factor receptor; Dose; Protein-tyrosine kinase; Food