The antibiotic ceftazidime is a singlet oxygen quencher as demonstrated by ultra-weak chemiluminescence and by inhibition of AAP consumption

• Published in: Biochimica et biophysica acta Vol. 1379; no. 1; pp. 61 - 68
• Main Authors: Deby-Dupont, Ginette, Deby, Carol, Mouithys-Mickalad, Ange, Hoebeke, Maryse, Mathy-Hartert, Marianne, Jadoul, Luc, Vandenberghe, Alain, Lamy, Maurice
• Format: Journal Article Web Resource
• Language: English
• Published: Netherlands Elsevier B.V 08.01.1998; Elsevier
• Subjects: Anthracene-9,10-dipropionic acid; Anthracenes - metabolism; Anti-Bacterial Agents; Antibiotic; Biochemistry, biophysics & molecular biology; Biochimie, biophysique & biologie moléculaire; Ceftazidime; Ceftazidime - metabolism; Cephalosporins - metabolism; Chemiluminescent Measurements; Free Radical Scavengers - metabolism; Histidine - metabolism; Hydrogen peroxide; Hydrogen Peroxide - metabolism; Hypochlorous acid; Hypochlorous Acid - metabolism; Life sciences; Light; Luminescent Measurements; Oxygen - metabolism; Photosensitivity Disorders; Propionates - metabolism; Reactive Oxygen Species - metabolism; Rose Bengal; Rose Bengal - metabolism; Sciences du vivant; Singlet Oxygen; Sodium Azide - metabolism; Spectrophotometry; Ultraweak chemiluminescence; Anthracene-9,10-dipropionic acid; Ultraweak chemiluminescence; Hydrogen peroxide; Hypochlorous acid; CL: Chemiluminescence; PMN(s): Polymorphonuclear leucocyte(s); Rose Bengal; RB: Rose Bengal; Antibiotic; uwCL: Ultra weak chemiluminescence; Singlet oxygen; CAZ: Ceftazidime; AAP: Anthracene-9,10-dipropionic acid; Ceftazidime; luCL: Luminol-mediated chemiluminescence

We demonstrated that the cephalosporin antibiotic ceftazidime (CAZ) deactivated singlet oxygen ( 1O 2). We then studied the mechanisms of the CAZ effects on the ultra weak chemiluminescence (uwCL) associated with the energy decay of 1O 2 generated by the Mallet reaction (H 2O 2+HOCl → HCl+H 2O+ 1O 2...