Regulation and function of skeletal muscle stem cells

Skeletal muscle satellite cells, which reside beneath the basal lamina of mature muscle fibers, function as myogenic precursors and are required for normal muscle growth and repair. Satellite cells share a common anatomical localization, yet they exhibit substantial phenotypic and functional heterog...

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Bibliographic Details
Published inCold Spring Harbor Symposia on Quantitative Biology Vol. 73; p. 317
Main Authors Cerletti, M, Shadrach, J L, Jurga, S, Sherwood, R, Wagers, A J
Format Journal Article
LanguageEnglish
Published United States 2008
Subjects
Aging - pathology
Animals
Cell Differentiation
Cell Separation
Humans
Mice
Muscle Development
Muscular Diseases - etiology
Muscular Diseases - pathology
Myoblasts, Skeletal - cytology
Myoblasts, Skeletal - physiology
Regeneration
Satellite Cells, Skeletal Muscle - cytology
Satellite Cells, Skeletal Muscle - physiology
Stem Cells - cytology
Stem Cells - physiology
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Summary:Skeletal muscle satellite cells, which reside beneath the basal lamina of mature muscle fibers, function as myogenic precursors and are required for normal muscle growth and repair. Satellite cells share a common anatomical localization, yet they exhibit substantial phenotypic and functional heterogeneity. Recent efforts in the field of adult myogenesis have been aimed at dissecting this heterogeneity and reveal the presence of discrete cell lineages within the muscle that function independently and interactively to maintain muscle homeostasis and to determine the outcome of muscle damage. Normal developmental regulation of the frequency and function of these distinct tissue precursors, and pathological deregulation of their activity, may have an important role in age- and disease-dependent loss of muscle regenerative activity.
ISSN:1943-4456
DOI:10.1101/sqb.2008.73.054