Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-A mice - Takada, Mayumi; Sumi, Mika; Maeda, Ayumi; Watanabe, Fumiko; Kamiya, Toshikazu; Ishii, Takeshi; Nakano, Masahiko; Akagawa, Mitsugu (Biochemical and biophysical research communications, 2012)
Keywords: Animals; Diabetes Mellitus, Experimental - enzymology; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Type 2 - enzymology; Diabetes Mellitus, Type 2 - metabolism; Enzyme Inhibitors - pharmacology; Glucose Intolerance - enzymology; Glucose Transporter Type 4 - metabolism; Insulin - metabolism; Mice; Mice, Inbred Strains; Muscle Fibers, Skeletal - drug effects; Muscle Fibers, Skeletal - enzymology; Muscle Fibers, Skeletal - metabolism; PQQ Cofactor - pharmacology; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors; Signal Transduction - drug effects