Impact of azelnidipine treatment on left ventricular diastolic performance in patients with hypertension and mild diastolic dysfunction: multi-center study with echocardiography

• Published in: Hypertension research Vol. 32; no. 10; pp. 895 - 900
• Main Authors: Ito, Hiroshi, Ishii, Katsuhisa, Iwakura, Katsuomi, Nakamura, Fumiaki, Nagano, Toshihiko, Takiuchi, Shin
• Format: Journal Article
• Language: English
• Published: England 01.10.2009
• Subjects: Adult; Aged; Aged, 80 and over; Azetidinecarboxylic Acid - analogs & derivatives; Azetidinecarboxylic Acid - therapeutic use; Calcium Channel Blockers - therapeutic use; Dihydropyridines - therapeutic use; Drug Therapy, Combination; Female; Humans; Hypertension - diagnostic imaging; Hypertension - drug therapy; Hypertension - physiopathology; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - drug therapy; Male; Middle Aged; Natriuretic Peptide, Brain - metabolism; Ultrasonography; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - drug therapy; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left - drug effects; Young Adult

We investigated the impact of lowering blood pressure (BP) with azelnidipine, a newly developed calcium channel blocker, generation on the left ventricular (LV) diastolic function and LV filling pressure by assessing non-invasive indices derived from echo Doppler study. This study evaluated 232 hype...