Synovial Fibroblasts Selectively Suppress Th1 Cell Responses through IDO1-Mediated Tryptophan Catabolism

• Published in: The Journal of immunology (1950) Vol. 198; no. 8; pp. 3109 - 3117
• Main Authors: Tykocinski, Lars-Oliver, Lauffer, Anna M, Bohnen, Antonia, Kaul, Nathalie-Christin, Krienke, Stefan, Tretter, Theresa, Adam, Isabell, Mohapatra, Soumya R, Saikali, Philippe, Löhning, Max, Neidhart, Michel, Gay, Steffen, Oezen, Iris, Platten, Michael, Opitz, Christiane A, Lorenz, Hanns-Martin
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 15.04.2017
• Subjects: Arthritis; Arthritis, Rheumatoid - immunology; Catabolism; Cell Differentiation - immunology; Cell growth; Cell proliferation; Chromatography, High Pressure Liquid; Coculture Techniques; Fibroblasts; Fibroblasts - immunology; Fibroblasts - metabolism; Helper cells; Humans; Immunoblotting; Immunosuppression; Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; Interferon; Lymphocyte Activation - immunology; Lymphocytes; Lymphocytes T; Metabolism; Molecular modelling; Osteoarthritis; Osteoarthritis - immunology; Phosphorylation; Polymerase Chain Reaction; Rheumatoid arthritis; Synovial Membrane - immunology; Synovitis; T cell receptors; Th1 Cells - immunology; Th17 Cells - immunology; Th2 Cells - immunology; Tryptophan; Tryptophan - immunology; Tryptophan - metabolism; γ-Interferon

The development of rheumatoid arthritis (RA) is linked to functional changes in synovial fibroblasts (SF) and local infiltration of T lymphocytes. Fibroblasts possess the capacity to suppress T cell responses, although the molecular mechanisms of this suppression remain incompletely understood. In t...