Prognostic role of lipid phosphate phosphatases in non-smoker, lung adenocarcinoma patients

• Published in: Computers in biology and medicine Vol. 129; p. 104141
• Main Authors: Nema, Rajeev, Shrivastava, Ashutosh, Kumar, Ashok
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.02.2021; Elsevier Limited
• Subjects: Adenocarcinoma; Biomarkers; Cancer therapies; Carcinogenesis; Carcinogens; Computer applications; Datasets; DNA methylation; Enzymes; Gene expression; Genomics; Immune system; Kinases; KM Plotter; Lipid phosphate phosphatase; Lipids; Lung cancer; Medical prognosis; Metabolism; Metabolites; mRNA; Non-small cell lung cancer; Non-small cell lung carcinoma; Phosphatase; Protein expression; Proteins; Receptor mechanisms; Receptors; Signal transduction; Signaling; Small cell lung carcinoma; Smoking; Software; Sphingosine 1-phosphate; Sphingosine kinase; Survival analysis; Tumor-infiltrating immune cells; Tumor-infiltrating lymphocytes; Tumorigenesis; Tumors; UALCAN database; Tumor-infiltrating immune cells; UALCAN database; KM Plotter; Lipid phosphate phosphatase; Sphingosine-1-phosphate; Non-small cell lung cancer

Sphingosine-1-phosphate (S1P), a bioactive sphingolipid, plays a crucial role in tumorigenesis. It mediates its function through S1P receptors. A few components of the S1P signaling pathway, such as sphingosine kinase 1 (SphK1) and S1P receptor 1 (S1PR1), have been shown to contribute to lung carcin...