Umbilical cord blood metabolomics reveal distinct signatures of dyslipidemia prior to bronchopulmonary dysplasia and pulmonary hypertension

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 315; no. 5; pp. L870 - L881
• Main Authors: La Frano, Michael R., Fahrmann, Johannes F., Grapov, Dmitry, Pedersen, Theresa L., Newman, John W., Fiehn, Oliver, Underwood, Mark A., Mestan, Karen, Steinhorn, Robin H., Wedgwood, Stephen
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2018
• Subjects: Biomarkers - metabolism; Bronchopulmonary Dysplasia - metabolism; Dyslipidemias - metabolism; Female; Fetal Blood - metabolism; Gestational Age; Humans; Hypertension, Pulmonary - metabolism; Infant, Newborn; Infant, Premature; Lipid Metabolism - physiology; Male; Metabolomics - methods; oxylipins; lipids; bronchopulmonary dysplasia; metabolomics; pulmonary hypertension

Pulmonary hypertension (PH) is a common consequence of bronchopulmonary dysplasia (BPD) and remains a primary contributor to increased morbidity and mortality among preterm infants. Unfortunately, at the present time, there are no reliable early predictive markers for BPD-associated PH. Considering...