Circulating SCUBE1 levels in women with polycystic ovary syndrome

• Published in: Turkish journal of obstetrics and gynecology Vol. 15; no. 3; pp. 152 - 158
• Main Authors: Erol, Onur, Ellidağ, Hamit Yaşar, Özel, Mustafa Kemal, Uysal Derbent, Aysel, Eren, Esin, Yılmaz, Necat
• Format: Journal Article
• Language: English
• Published: Turkey Türk Jinekoloji ve Obstetrik Derneği 01.09.2018; Galenos Publishing House; Galenos Publishing
• Subjects: Acute coronary syndromes; Amenorrhea; Androgens; Atherosclerosis; Blood platelets; Body mass index; Cardiovascular disease; Clinical Investigation; Congenital diseases; Diabetes; Epidermal growth factor; Glucose; Insulin resistance; Kadın Hastalıkları; Menstruation; Metabolism; Obesity; Peptides; Polycystic ovary syndrome; Proteins; Thromboembolism; Tıp; Ultrasonic imaging; Ankara; Türkiye; Polycystic ovary syndrome; Platelet activation; SCUBE1; Polikistik over sendromu; Trombosit aktivasyonu
• DOI: 10.4274/tjod.25826
• ISSN: 2149-9322

Polycystic ovary syndrome (PCOS) is thought to represent an early manifestation of metabolic syndrome, which is associated with cardiovascular disease. Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-epidermal growth factor domain-containing protein 1 (SCUBE1) is a platelet activation marker that plays important roles in vascular biology and has been closely linked to cardiovascular events. In the present study, we investigated SCUBE1 levels in lean glucose-tolerant women with PCOS and assessed the possible association between SCUBE1 levels and hormonal and metabolic features of women with PCOS. The study population consisted of 90 lean [body mass index (BMI) <25 kg/m ] women who were diagnosed as having PCOS using the Rotterdam criteria and 100 age- and BMI-matched healthy controls with no clinical or biochemical feature of hyperandrogenism. Glucose tolerance was evaluated in all subjects before recruitment using the 2 h 75 g oral glucose tolerance test, and only those exhibiting normal glucose tolerance were enrolled. Hormonal and metabolic parameters, and serum SCUBE1 levels were evaluated. Circulating SCUBE1 levels were significantly higher in women with PCOS than in controls (5.9±3.9 vs. 4.2±1.4 ng/mL, p=0.022). No association between SCUBE1 level and clinical or biochemical parameters was found in the control or PCOS group. SCUBE1 levels are elevated in women with PCOS compared with those in healthy controls; thus, this protein may be an early biomarker of cardiovascular disease later in life.