Siponimod therapy implicates Th17 cells in a preclinical model of subpial cortical injury

• Published in: JCI insight Vol. 5; no. 1
• Main Authors: Ward, Lesley A, Lee, Dennis Sw, Sharma, Anshu, Wang, Angela, Naouar, Ikbel, Ma, Xianjie I, Pikor, Natalia, Nuesslein-Hildesheim, Barbara, Ramaglia, Valeria, Gommerman, Jennifer L
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 16.01.2020
• Subjects: Adoptive Transfer; Animals; Azetidines - therapeutic use; Benzyl Compounds - therapeutic use; Brain - pathology; Cytidine Deaminase - genetics; Cytokines - immunology; Disease Progression; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - pathology; Female; Immunoglobulin G; Immunoglobulin M; Inflammation - pathology; Macrophages; Meninges; Mice; Mice, Inbred C57BL; Microglia - pathology; Multiple Sclerosis - immunology; Myelin-Oligodendrocyte Glycoprotein - immunology; Neuroglia; Th17 Cells - drug effects; Th17 Cells - immunology; Multiple sclerosis; Immunology; T cells; Mouse models

Subpial demyelination is a specific hallmark of multiple sclerosis and a correlate of disease progression. Although the mechanism(s) that mediate pathogenesis in the subpial compartment remain unclear, it has been speculated that inflammation in the overlying meninges may be associated with subpial...