Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer

• Published in: American journal of respiratory and critical care medicine Vol. 198; no. 9; pp. 1188 - 1198
• Main Authors: Tsay, Jun-Chieh J., Wu, Benjamin G., Badri, Michelle H., Clemente, Jose C., Shen, Nan, Meyn, Peter, Li, Yonghua, Yie, Ting-An, Lhakhang, Tenzin, Olsen, Evan, Murthy, Vivek, Michaud, Gaetane, Sulaiman, Imran, Tsirigos, Aristotelis, Heguy, Adriana, Pass, Harvey, Weiden, Michael D., Rom, William N., Sterman, Daniel H., Bonneau, Richard, Blaser, Martin J., Segal, Leopoldo N.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.11.2018
• Subjects: Adult; Aged; Bronchoscopy; Cross-Sectional Studies; Female; Humans; Lung Neoplasms - enzymology; Lung Neoplasms - metabolism; Lung Neoplasms - microbiology; Male; Microbiota - physiology; Middle Aged; Original Research; Phosphatidylinositol 3-Kinases - metabolism; Prospective Studies; Respiratory System - enzymology; Respiratory System - metabolism; Respiratory System - microbiology; Up-Regulation - physiology; lung cancer; microbiome; bronchoscopy

In lung cancer, upregulation of the PI3K (phosphoinositide 3-kinase) pathway is an early event that contributes to cell proliferation, survival, and tissue invasion. Upregulation of this pathway was recently described as associated with enrichment of the lower airways with bacteria identified as ora...