Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation - Godavarthy, Aparna; Kelly, Ryan; Jimah, John; Beckford, Miguel; Caza, Tiffany; Fernandez, David; Huang, Nick; Duarte, Manuel; Lewis, Joshua; Fadel, Hind J.; Poeschla, Eric M.; Banki, Katalin; et al. (JCI insight, 2020)
Keywords: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Alleles; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Endogenous Retroviruses - genetics; Epigenesis, Genetic; Female; HCT116 Cells; HeLa Cells; Humans; Lupus Erythematosus, Systemic - genetics; Middle Aged; Nuclear Respiratory Factor 1; Receptors, Antigen, T-Cell; T-Lymphocytes; Terminal Repeat Sequences - genetics; Terminal Repeat Sequences - physiology; TOR Serine-Threonine Kinases - genetics; Transcription Factors; Young Adult; Lupus; Immunology; T cells; Rheumatology