Tear metabolite changes in keratoconus
While efforts have been made over the years, the exact cause of keratoconus (KC) remains unknown. The aim of this study was to identify alterations in endogenous metabolites in the tears of KC patients compared with age-matched healthy subjects. Three groups were tested: 1) Age-matched controls with...
Saved in:
| Published in | Experimental eye research Vol. 132; pp. 1 - 8 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.03.2015
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0014-4835 1096-0007 1096-0007 |
| DOI | 10.1016/j.exer.2015.01.007 |
Cover
Loading…
| Abstract | While efforts have been made over the years, the exact cause of keratoconus (KC) remains unknown. The aim of this study was to identify alterations in endogenous metabolites in the tears of KC patients compared with age-matched healthy subjects. Three groups were tested: 1) Age-matched controls with no eye disease (N = 15), 2) KC - patients wearing Rigid Gas permeable lenses (N = 16), and 3) KC - No Correction (N = 14). All samples were processed for metabolomics analysis using LC-MS/MS. We identified a total of 296 different metabolites of which >40 were significantly regulated between groups. Glycolysis and gluconeogenesis had significant changes, such as 3-phosphoglycerate and 1,3 diphosphateglycerate. As a result the citric acid cycle (TCA) was also affected with notable changes in Isocitrate, aconitate, malate, and acetylphosphate, up regulated in Group 2 and/or 3. Urea cycle was also affected, especially in Group 3 where ornithine and aspartate were up-regulated by at least 3 fold. The oxidation state was also severely affected. Groups 2 and 3 were under severe oxidative stress causing multiple metabolites to be regulated when compared to Group 1. Group 2 and 3, both showed significant down regulation in GSH-to-GSSG ratio when compared to Group 1. Another indicator of oxidative stress, the ratio of lactate - pyruvate was also affected with Groups 2 and 3 showing at least a 2-fold up regulation. Overall, our data indicate that levels of metabolites related to urea cycle, TCA cycle and oxidative stress are highly altered in KC patients. |
|---|---|
| AbstractList | While efforts have been made over the years, the exact cause of keratoconus (KC) remains unknown. The aim of this study was to identify alterations in endogenous metabolites in the tears of KC patients compared with age-matched healthy subjects. Three groups were tested: 1) Age-matched controls with no eye disease (N = 15), 2) KC - patients wearing Rigid Gas permeable lenses (N = 16), and 3) KC - No Correction (N = 14). All samples were processed for metabolomics analysis using LC-MS/MS. We identified a total of 296 different metabolites of which >40 were significantly regulated between groups. Glycolysis and gluconeogenesis had significant changes, such as 3-phosphoglycerate and 1,3 diphosphateglycerate. As a result the citric acid cycle (TCA) was also affected with notable changes in Isocitrate, aconitate, malate, and acetylphosphate, up regulated in Group 2 and/or 3. Urea cycle was also affected, especially in Group 3 where ornithine and aspartate were up-regulated by at least 3 fold. The oxidation state was also severely affected. Groups 2 and 3 were under severe oxidative stress causing multiple metabolites to be regulated when compared to Group 1. Group 2 and 3, both showed significant down regulation in GSH-to-GSSG ratio when compared to Group 1. Another indicator of oxidative stress, the ratio of lactate - pyruvate was also affected with Groups 2 and 3 showing at least a 2-fold up regulation. Overall, our data indicate that levels of metabolites related to urea cycle, TCA cycle and oxidative stress are highly altered in KC patients.While efforts have been made over the years, the exact cause of keratoconus (KC) remains unknown. The aim of this study was to identify alterations in endogenous metabolites in the tears of KC patients compared with age-matched healthy subjects. Three groups were tested: 1) Age-matched controls with no eye disease (N = 15), 2) KC - patients wearing Rigid Gas permeable lenses (N = 16), and 3) KC - No Correction (N = 14). All samples were processed for metabolomics analysis using LC-MS/MS. We identified a total of 296 different metabolites of which >40 were significantly regulated between groups. Glycolysis and gluconeogenesis had significant changes, such as 3-phosphoglycerate and 1,3 diphosphateglycerate. As a result the citric acid cycle (TCA) was also affected with notable changes in Isocitrate, aconitate, malate, and acetylphosphate, up regulated in Group 2 and/or 3. Urea cycle was also affected, especially in Group 3 where ornithine and aspartate were up-regulated by at least 3 fold. The oxidation state was also severely affected. Groups 2 and 3 were under severe oxidative stress causing multiple metabolites to be regulated when compared to Group 1. Group 2 and 3, both showed significant down regulation in GSH-to-GSSG ratio when compared to Group 1. Another indicator of oxidative stress, the ratio of lactate - pyruvate was also affected with Groups 2 and 3 showing at least a 2-fold up regulation. Overall, our data indicate that levels of metabolites related to urea cycle, TCA cycle and oxidative stress are highly altered in KC patients. While efforts have been made over the years, the exact cause of keratoconus (KC) remains unknown. The aim of this study was to identify alterations in endogenous metabolites in the tears of KC patients compared with age-matched healthy subjects. Three groups were tested: 1) Age-matched controls with no eye disease (N = 15), 2) KC - patients wearing Rigid Gas permeable lenses (N = 16), and 3) KC - No Correction (N = 14). All samples were processed for metabolomics analysis using LC-MS/MS. We identified a total of 296 different metabolites of which >40 were significantly regulated between groups. Glycolysis and gluconeogenesis had significant changes, such as 3-phosphoglycerate and 1,3 diphosphateglycerate. As a result the citric acid cycle (TCA) was also affected with notable changes in Isocitrate, aconitate, malate, and acetylphosphate, up regulated in Group 2 and/or 3. Urea cycle was also affected, especially in Group 3 where ornithine and aspartate were up-regulated by at least 3 fold. The oxidation state was also severely affected. Groups 2 and 3 were under severe oxidative stress causing multiple metabolites to be regulated when compared to Group 1. Group 2 and 3, both showed significant down regulation in GSH-to-GSSG ratio when compared to Group 1. Another indicator of oxidative stress, the ratio of lactate - pyruvate was also affected with Groups 2 and 3 showing at least a 2-fold up regulation. Overall, our data indicate that levels of metabolites related to urea cycle, TCA cycle and oxidative stress are highly altered in KC patients. While efforts have been made over the years, the exact cause of keratoconus (KC) remains unknown. The aim of this study was to identify alterations in endogenous metabolites in the tears of KC patients compared with age-matched healthy subjects. Three groups were tested: 1) Age-matched controls with no eye disease (N=15), 2) KC – patients wearing Rigid Gas permeable lenses (N=16), and 3) KC – No Correction (N=14). All samples were processed for metabolomics analysis using LC-MS/MS. We identified a total of 296 different metabolites of which >40 were significantly regulated between groups. Glycolysis and gluconeogenesis had significant changes, such as 3-phosphoglycerate and 1,3 diphopshateglycerate. As a result the citric acid cycle (TCA) was also affected with notable changes in Isocitrate, aconitate, malate, and acetylphosphate, up regulated in Group 2 and/or 3. Urea cycle was also affected, especially in Group 3 where ornithine and aspartate were up-regulated by at least 3 fold. The oxidation state was also severely affected. Groups 2 and 3 were under severe oxidative stress causing multiple metabolites to be regulated when compared to Group 1. Group 2 and 3, both showed significant down regulation in GSH-to-GSSG ratio when compared to Group 1. Another indicator of oxidative stress, the ratio of lactate – pyruvate was also affected with Groups 2 and 3 showing at least a 2-fold up regulation. Overall, our data indicate that levels of metabolites related to urea cycle, TCA cycle and oxidative stress are highly altered in KC patients. |
| Author | Sarker-Nag, A. Karamichos, D. Sejersen, H. Hjortdal, J. Asara, John M. Zieske, J.D. |
| AuthorAffiliation | 1 Ophthalmology, University of Oklahoma - Dean McGee Eye Institute, Oklahoma City, OK 4 Division of Signal Transduction/Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA 2 Schepens Eye Research Institute/Massachusetts Eye and Ear and the Department of Ophthalmology Harvard Medical School, 20 Staniiford Street, Boston, MA, USA 3 Department of Ophthalmology, Aarhus University Hospital, Aarhus C, Denmark |
| AuthorAffiliation_xml | – name: 2 Schepens Eye Research Institute/Massachusetts Eye and Ear and the Department of Ophthalmology Harvard Medical School, 20 Staniiford Street, Boston, MA, USA – name: 4 Division of Signal Transduction/Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA – name: 1 Ophthalmology, University of Oklahoma - Dean McGee Eye Institute, Oklahoma City, OK – name: 3 Department of Ophthalmology, Aarhus University Hospital, Aarhus C, Denmark |
| Author_xml | – sequence: 1 givenname: D. surname: Karamichos fullname: Karamichos, D. – sequence: 2 givenname: J.D. surname: Zieske fullname: Zieske, J.D. – sequence: 3 givenname: H. surname: Sejersen fullname: Sejersen, H. – sequence: 4 givenname: A. surname: Sarker-Nag fullname: Sarker-Nag, A. – sequence: 5 givenname: John M. surname: Asara fullname: Asara, John M. – sequence: 6 givenname: J. surname: Hjortdal fullname: Hjortdal, J. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25579606$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UU1LAzEQDVKxH_oHPEhP4mXXycemuxdBil9Q8FLPIZvOtqnbTU22ov_elNaiHhwYZsi89ybM65NO4xok5JxCSoHK62WKH-hTBjRLgaYAoyPSo1DIBGLfIT0AKhKR86xL-iEs4ysXI3FCuizLRoUE2SOXU9R-uMJWl662LQ7NQjdzDEPbDF_R69YZ12zCKTmudB3wbF8H5OX-bjp-TCbPD0_j20liBLA20RlWpqwEcJ5zls8ypEwXpcEMNas4lrLkIiYrpKgkiz0gIoVqpgueM80H5Ganu96UK5wZbFqva7X2dqX9p3Laqt-Txi7U3L0rIbiURR4FrvYC3r1tMLRqZYPButYNuk1QVErKY1AaoRc_dx2WfB8nAtgOYLwLwWN1gFBQWwfUUm0dUFsHFFAVrx5J-R-Ssa1urdv-19b_Ub8A2wGNOw |
| CitedBy_id | crossref_primary_10_1038_s41598_024_74455_9 crossref_primary_10_1167_iovs_18_24267 crossref_primary_10_1016_j_exer_2022_109242 crossref_primary_10_3390_metabo12030272 crossref_primary_10_1007_s13167_023_00313_9 crossref_primary_10_1007_s11306_017_1281_0 crossref_primary_10_1016_j_jfo_2025_104446 crossref_primary_10_1080_17469899_2024_2368801 crossref_primary_10_3390_nu14040913 crossref_primary_10_1002_pmic_202100416 crossref_primary_10_3390_bios14100483 crossref_primary_10_1186_s13167_016_0065_3 crossref_primary_10_1016_j_oftal_2015_09_010 crossref_primary_10_1111_aos_14714 crossref_primary_10_1194_jlr_M067264 crossref_primary_10_1016_j_exer_2021_108804 crossref_primary_10_1016_j_exer_2019_107897 crossref_primary_10_1371_journal_pone_0177749 crossref_primary_10_1016_j_joco_2019_06_003 crossref_primary_10_1371_journal_pone_0176017 crossref_primary_10_1002_cbf_3122 crossref_primary_10_1016_j_ab_2021_114174 crossref_primary_10_1371_journal_pone_0186258 crossref_primary_10_1016_j_exer_2018_10_006 crossref_primary_10_1055_a_1002_0100 crossref_primary_10_4102_aveh_v75i1_339 crossref_primary_10_1038_s41598_019_48983_8 crossref_primary_10_1167_iovs_63_2_17 crossref_primary_10_1016_j_exer_2022_109101 crossref_primary_10_1016_j_exer_2021_108734 crossref_primary_10_1155_2020_9410952 crossref_primary_10_3390_cells8101239 crossref_primary_10_5582_bst_2019_01178 crossref_primary_10_1002_elps_201500272 crossref_primary_10_1016_j_aca_2018_01_060 crossref_primary_10_1016_j_exer_2022_109062 crossref_primary_10_3390_metabo13030380 crossref_primary_10_1007_s00417_020_05058_z crossref_primary_10_1038_s41598_018_30032_5 crossref_primary_10_1016_j_survophthal_2022_01_010 crossref_primary_10_3390_ijms25021052 crossref_primary_10_1038_s41433_018_0075_6 crossref_primary_10_3389_fcell_2020_00344 crossref_primary_10_3390_molecules25122933 crossref_primary_10_1016_j_oftale_2015_09_007 crossref_primary_10_1038_eye_2016_37 crossref_primary_10_1007_s00417_023_06064_7 crossref_primary_10_1038_s41598_019_50095_2 crossref_primary_10_1186_s40662_016_0051_9 crossref_primary_10_1016_j_exer_2018_10_015 crossref_primary_10_1007_s00417_020_04900_8 crossref_primary_10_5005_jp_journals_10025_1157 crossref_primary_10_1016_j_clae_2018_12_004 crossref_primary_10_3109_02713683_2015_1078361 crossref_primary_10_1007_s11306_019_1545_y crossref_primary_10_1016_j_exer_2020_108401 crossref_primary_10_1016_j_exer_2021_108665 crossref_primary_10_5507_bp_2020_028 crossref_primary_10_1021_acsmeasuresciau_3c00067 crossref_primary_10_1167_tvst_7_6_22 crossref_primary_10_1167_iovs_19_27151 crossref_primary_10_1038_s41421_022_00397_z crossref_primary_10_1097_ICL_0000000000000644 crossref_primary_10_1167_iovs_63_8_7 crossref_primary_10_1038_s41598_019_39182_6 |
| Cites_doi | 10.1167/iovs.11-7732 10.1097/01.ico.0000153556.59407.69 10.1167/iovs.05-1530 10.1097/ICO.0b013e31818d37fa 10.1001/archopht.1968.00980050432004 10.1167/iovs.12-9475 10.1016/j.ajo.2006.07.026 10.5936/csbj.201301003 10.1097/ICO.0b013e31820f777b 10.1002/eji.201141683 10.1016/j.exer.2011.01.008 10.1097/01.opx.0000192349.11525.de 10.1097/00006324-199612000-00002 10.1152/ajpcell.1985.249.5.C409 10.1177/002215540205000306 10.1167/iovs.03-1292 10.1097/00003226-199401000-00012 10.1016/j.clae.2007.03.001 10.1016/j.jprot.2013.05.023 10.1076/ceyr.22.5.333.5491 10.4103/0974-9233.75876 10.1016/S0161-6420(99)00027-5 10.3341/kjo.2010.24.4.201 10.1053/siny.2001.0085 10.1097/00003226-199307000-00006 10.1097/00003226-199303000-00010 10.1097/00006324-198709000-00009 10.1016/0039-6257(85)90063-3 10.1016/S1542-0124(12)70233-1 10.1016/j.exer.2012.07.010 10.1016/j.jpsychires.2012.11.003 10.1006/abbi.1994.1167 10.1113/jphysiol.1981.sp013971 10.1097/WOX.0b013e3182439613 10.1016/j.copbio.2012.10.003 10.1038/nprot.2012.024 10.1016/S0886-3350(03)00230-X 10.1016/0014-5793(86)80621-4 10.3892/ol.2012.931 10.1590/S0004-27492007000200023 10.1002/ajmg.a.20326 10.1111/j.1755-3768.2012.02400.x 10.1055/s-2006-927144 10.1016/j.exer.2005.06.009 10.1016/S0039-6257(97)00119-7 10.1016/j.clae.2010.04.006 10.1038/srep04608 10.1016/0039-6257(84)90094-8 10.1167/iovs.04-1395 10.1371/journal.pgen.1000282 10.3168/jds.S0022-0302(77)83821-6 |
| ContentType | Journal Article |
| Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. 2015 Elsevier Ltd. All rights reserved. 2015 |
| Copyright_xml | – notice: Copyright © 2015 Elsevier Ltd. All rights reserved. – notice: 2015 Elsevier Ltd. All rights reserved. 2015 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1016/j.exer.2015.01.007 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1096-0007 |
| EndPage | 8 |
| ExternalDocumentID | PMC4436698 25579606 10_1016_j_exer_2015_01_007 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: 5P30CA006516 – fundername: NEI NIH HHS grantid: P30 EY021725 – fundername: NCI NIH HHS grantid: P01 CA120964 – fundername: NCI NIH HHS grantid: P30 CA006516 – fundername: NCI NIH HHS grantid: 2P01CA120964 – fundername: NEI NIH HHS grantid: R01 EY023568 – fundername: NEI NIH HHS grantid: 5R01EY023568 |
| GroupedDBID | --- --K --M .55 .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29G 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AAAJQ AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAXKI AAXLA AAXUO AAYWO AAYXX ABBQC ABCQJ ABFNM ABJNI ABLJU ABMAC ABMZM ABWVN ABXDB ACDAQ ACGFS ACIEU ACNCT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADFGL ADMUD ADNMO AEBSH AEIPS AEKER AENEX AEUPX AFFNX AFJKZ AFPUW AFTJW AFXIZ AGCQF AGEKW AGHFR AGQPQ AGRNS AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 CAG CITATION CJTIS COF CS3 DM4 DU5 EBS EFBJH EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEA HMK HMO HMQ HVGLF HZ~ IHE J1W KOM L7B LG5 LUGTX LZ2 M29 M2U M41 MO0 MOBAO MVM N9A O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SES SEW SNS SPCBC SSH SSI SSN SSZ T5K TEORI WUQ X7M XPP ZGI ZMT ZU3 ~G- AACTN CGR CUY CVF ECM EIF NPM 7X8 5PM EFKBS |
| ID | FETCH-LOGICAL-c402t-a5efcbf40338328d5e12a9bce5ea2f3eb6b346b32964f623460eee10fda9382a3 |
| ISSN | 0014-4835 1096-0007 |
| IngestDate | Thu Aug 21 17:17:08 EDT 2025 Fri Jul 11 02:54:14 EDT 2025 Thu Apr 03 07:01:50 EDT 2025 Tue Jul 01 03:22:51 EDT 2025 Thu Apr 24 22:59:24 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Metabolomics Oxidative stress Pentacam Rigid Gas Permeable lenses Keratoconus |
| Language | English |
| License | Copyright © 2015 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c402t-a5efcbf40338328d5e12a9bce5ea2f3eb6b346b32964f623460eee10fda9382a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/4436698 |
| PMID | 25579606 |
| PQID | 1661333311 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4436698 proquest_miscellaneous_1661333311 pubmed_primary_25579606 crossref_primary_10_1016_j_exer_2015_01_007 crossref_citationtrail_10_1016_j_exer_2015_01_007 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2015-03-01 |
| PublicationDateYYYYMMDD | 2015-03-01 |
| PublicationDate_xml | – month: 03 year: 2015 text: 2015-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Experimental eye research |
| PublicationTitleAlternate | Exp Eye Res |
| PublicationYear | 2015 |
| References | Wang (10.1016/j.exer.2015.01.007_bib62) 2002; 28 Booth (10.1016/j.exer.2015.01.007_bib11) 2013; 4 Karamichos (10.1016/j.exer.2015.01.007_bib32) 2014; 4 Leonard (10.1016/j.exer.2015.01.007_bib37) 2002; 7 Wahrendorf (10.1016/j.exer.2015.01.007_bib61) 2006; 223 Adamski (10.1016/j.exer.2015.01.007_bib1) 2013; 24 Nielsen (10.1016/j.exer.2015.01.007_bib48) 2013; 91 Aldave (10.1016/j.exer.2015.01.007_bib4) 2006; 47 Gondhowiardjo (10.1016/j.exer.2015.01.007_bib23) 1993; 12 Jinabhai (10.1016/j.exer.2015.01.007_bib30) 2012; 31 Monty (10.1016/j.exer.2015.01.007_bib43) 2003 Barnes (10.1016/j.exer.2015.01.007_bib7) 1986; 201 Klyce (10.1016/j.exer.2015.01.007_bib34) 1981; 321 Chai (10.1016/j.exer.2015.01.007_bib16) 1994; 310 Arnal (10.1016/j.exer.2015.01.007_bib5) 2011; 52 Maurice (10.1016/j.exer.2015.01.007_bib40) 1965 Brusilow (10.1016/j.exer.2015.01.007_bib13) 2001 Buddi (10.1016/j.exer.2015.01.007_bib14) 2002; 50 Nelson (10.1016/j.exer.2015.01.007_bib45) 2000 Romero-Jiménez (10.1016/j.exer.2015.01.007_bib53) 2014 Young (10.1016/j.exer.2015.01.007_bib65) 1977; 60 Lane (10.1016/j.exer.2015.01.007_bib36) 2009 Moreira (10.1016/j.exer.2015.01.007_bib44) 2007; 70 Birben (10.1016/j.exer.2015.01.007_bib10) 2012; 5 Saijyothi (10.1016/j.exer.2015.01.007_bib55) 2012; 103 Montes-Mico (10.1016/j.exer.2015.01.007_bib42) 2010; 8 Friend (10.1016/j.exer.2015.01.007_bib19) 1983 Zadnik (10.1016/j.exer.2015.01.007_bib67) 2005; 82 Gieger (10.1016/j.exer.2015.01.007_bib22) 2008; 4 Nowak (10.1016/j.exer.2015.01.007_bib50) 2011; 18 Chaerkady (10.1016/j.exer.2015.01.007_bib15) 2013; 87 Braun (10.1016/j.exer.2015.01.007_bib12) 2003; 29 Zadnik (10.1016/j.exer.2015.01.007_bib68) 1987; 64 Kenney (10.1016/j.exer.2015.01.007_bib33) 2000; 26 Greiner (10.1016/j.exer.2015.01.007_bib26) 1985; 30 Risa (10.1016/j.exer.2015.01.007_bib52) 2004; 45 Gordon (10.1016/j.exer.2015.01.007_bib25) 2006; 142 Srivastava (10.1016/j.exer.2015.01.007_bib56) 2006; 12 Gondhowiardjo (10.1016/j.exer.2015.01.007_bib24) 1993; 12 Esgin (10.1016/j.exer.2015.01.007_bib18) 2002; 28 Nielsen (10.1016/j.exer.2015.01.007_bib49) 2006; 82 Yuan (10.1016/j.exer.2015.01.007_bib66) 2012; 7 Liu (10.1016/j.exer.2015.01.007_bib38) 2000; 107 Bechrakis (10.1016/j.exer.2015.01.007_bib8) 1994; 13 Holden (10.1016/j.exer.2015.01.007_bib28) 1985; 26 Lowenstein (10.1016/j.exer.2015.01.007_bib39) 1969; vol. 13 Cheng (10.1016/j.exer.2015.01.007_bib17) 2001; 22 Romero-Jimenez (10.1016/j.exer.2015.01.007_bib54) 2010; 33 Atilano (10.1016/j.exer.2015.01.007_bib6) 2005; 46 Alberts (10.1016/j.exer.2015.01.007_bib3) 2001 Webhofer (10.1016/j.exer.2015.01.007_bib63) 2013; 47 Joseph (10.1016/j.exer.2015.01.007_bib31) 2011; 92 Wagner (10.1016/j.exer.2015.01.007_bib60) 2007; 30 Krachmer (10.1016/j.exer.2015.01.007_bib35) 1984; 28 Miller (10.1016/j.exer.2015.01.007_bib41) 1968; 80 Fu (10.1016/j.exer.2015.01.007_bib20) 2011; 41 Rabinowitz (10.1016/j.exer.2015.01.007_bib51) 1998; 42 Nguyen (10.1016/j.exer.2015.01.007_bib46) 2012; 53 Behndig (10.1016/j.exer.2015.01.007_bib9) 2001; 42 Gundel (10.1016/j.exer.2015.01.007_bib27) 1996; 73 Yeniad (10.1016/j.exer.2015.01.007_bib64) 2009; 28 Al-Hussain (10.1016/j.exer.2015.01.007_bib2) 2004; 124A Germann (10.1016/j.exer.2015.01.007_bib21) 2002 Zitka (10.1016/j.exer.2015.01.007_bib69) 2012; 4 Hwang (10.1016/j.exer.2015.01.007_bib29) 2010; 24 Nielsen (10.1016/j.exer.2015.01.007_bib47) 2005; 24 Thies (10.1016/j.exer.2015.01.007_bib58) 1985; 249 Szczotka (10.1016/j.exer.2015.01.007_bib57) 1996; 22 11850437 - J Histochem Cytochem. 2002 Mar;50(3):341-51 3933363 - Am J Physiol. 1985 Nov;249(5 Pt 1):C409-16 20537579 - Cont Lens Anterior Eye. 2010 Aug;33(4):157-66; quiz 205 12069536 - Semin Neonatol. 2002 Feb;7(1):27-35 20714382 - Korean J Ophthalmol. 2010 Aug;24(4):201-6 8339559 - Cornea. 1993 Jul;12(4):310-4 21572727 - Middle East Afr J Ophthalmol. 2011 Jan;18(1):2-6 23727491 - J Proteomics. 2013 Jul 11;87:122-31 10656302 - CLAO J. 2000 Jan;26(1):10-3 23207114 - J Psychiatr Res. 2013 Mar;47(3):289-98 5674798 - Arch Ophthalmol. 1968 Oct;80(4):430-2 8161216 - Arch Biochem Biophys. 1994 Apr;310(1):273-81 23268465 - World Allergy Organ J. 2012 Jan;5(1):9-19 23205122 - Oncol Lett. 2012 Dec;4(6):1247-1253 11527942 - Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2293-6 17481941 - Cont Lens Anterior Eye. 2007 Sep;30(4):223-32 16357642 - Optom Vis Sci. 2005 Dec;82(12):1014-21 3909470 - Surv Ophthalmol. 1985 Nov-Dec;30(3):189-202 17589706 - Arq Bras Oftalmol. 2007 Mar-Apr;70(2):317-22 22314817 - Cornea. 2012 May;31(5):500-8 16083875 - Exp Eye Res. 2006 Feb;82(2):201-9 8131410 - Cornea. 1994 Jan;13(1):73-7 9002088 - Optom Vis Sci. 1996 Dec;73(12):729-32 11600933 - Curr Eye Res. 2001 May;22(5):333-40 11838988 - CLAO J. 2002 Jan;28(1):40-3 7338822 - J Physiol. 1981 Dec;321:49-64 17200661 - Mol Vis. 2006;12:1615-25 6230745 - Surv Ophthalmol. 1984 Jan-Feb;28(4):293-322 12394539 - CLAO J. 2002 Oct;28(4):169-71 12900239 - J Cataract Refract Surg. 2003 Jul;29(7):1319-22 10647727 - Ophthalmology. 2000 Jan;107(1):105-11 9493273 - Surv Ophthalmol. 1998 Jan-Feb;42(4):297-319 3086126 - FEBS Lett. 1986 Jun 9;201(2):267-70 8500322 - Cornea. 1993 Mar;12(2):146-54 16015083 - Cornea. 2005 Aug;24(6):661-8 16799019 - Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2820-2 19043545 - PLoS Genet. 2008 Nov;4(11):e1000282 23102864 - Curr Opin Biotechnol. 2013 Feb;24(1):39-47 7712741 - Cornea. 1995 Jan;14(1):77-83 14679583 - Am J Med Genet A. 2004 Jan 1;124A(1):28-34 15161858 - Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1916-21 15790887 - Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1256-63 21969298 - Invest Ophthalmol Vis Sci. 2011;52(12):8592-7 21805470 - Eur J Immunol. 2011 Oct;41(10):2997-3005 17157577 - Am J Ophthalmol. 2006 Dec;142(6):923-30 22960318 - Exp Eye Res. 2012 Oct;103:41-6 3688191 - Am J Optom Physiol Opt. 1987 Sep;64(9):698-702 320235 - J Dairy Sci. 1977 Jan;60(1):1-15 22410572 - Invest Ophthalmol Vis Sci. 2012 Apr;53(4):2020-9 22498707 - Nat Protoc. 2012 May;7(5):872-81 22471291 - Acta Ophthalmol. 2013 Mar;91(2):106-13 25199441 - J Optom. 2015 Jan-Mar;8(1):48-55 8906386 - CLAO J. 1996 Oct;22(4):270-3 17131247 - Klin Monbl Augenheilkd. 2006 Nov;223(11):877-88 21281627 - Exp Eye Res. 2011 Apr;92(4):282-98 3863808 - Invest Ophthalmol Vis Sci. 1985 Nov;26(11):1489-501 20964981 - Ocul Surf. 2010 Oct;8(4):185-92 24714342 - Sci Rep. 2014;4:4608 24688685 - Comput Struct Biotechnol J. 2013 Feb 06;4:e201301003 19411974 - Cornea. 2009 May;28(4):477-9 |
| References_xml | – volume: 52 start-page: 8592 year: 2011 ident: 10.1016/j.exer.2015.01.007_bib5 article-title: Oxidative stress in keratoconus? publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.11-7732 – volume: 24 start-page: 661 year: 2005 ident: 10.1016/j.exer.2015.01.007_bib47 article-title: Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients publication-title: Cornea doi: 10.1097/01.ico.0000153556.59407.69 – volume: 47 start-page: 2820 year: 2006 ident: 10.1016/j.exer.2015.01.007_bib4 article-title: No VSX1 gene mutations associated with keratoconus publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.05-1530 – volume: 28 start-page: 477 year: 2009 ident: 10.1016/j.exer.2015.01.007_bib64 article-title: Eye rubbing as an apparent cause of recurrent keratoconus publication-title: Cornea doi: 10.1097/ICO.0b013e31818d37fa – volume: 26 start-page: 1489 year: 1985 ident: 10.1016/j.exer.2015.01.007_bib28 article-title: Effects of long-term extended contact lens wear on the human cornea publication-title: Investig. Ophthalmol. Vis. Sci. – start-page: 973 year: 2003 ident: 10.1016/j.exer.2015.01.007_bib43 – volume: 80 start-page: 430 year: 1968 ident: 10.1016/j.exer.2015.01.007_bib41 article-title: Contact lens-induced corneal curvature and thickness changes publication-title: Arch. Ophthalmol. doi: 10.1001/archopht.1968.00980050432004 – start-page: 1909 year: 2001 ident: 10.1016/j.exer.2015.01.007_bib13 article-title: Urea cycle enzymes – volume: 53 start-page: 2020 year: 2012 ident: 10.1016/j.exer.2015.01.007_bib46 article-title: Lactate-H⁺ transport is a significant component of the in vivo corneal endothelial pump publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-9475 – volume: 142 start-page: 923 year: 2006 ident: 10.1016/j.exer.2015.01.007_bib25 article-title: Baseline factors predictive of incident penetrating keratoplasty in keratoconus publication-title: Am. J. Ophthalmol. doi: 10.1016/j.ajo.2006.07.026 – year: 2009 ident: 10.1016/j.exer.2015.01.007_bib36 – volume: 4 start-page: e201301003 year: 2013 ident: 10.1016/j.exer.2015.01.007_bib11 article-title: Computational tools for the secondary analysis of metabolomics experiments publication-title: Comput. Struct. Biotechnol. J. doi: 10.5936/csbj.201301003 – volume: 31 start-page: 500 year: 2012 ident: 10.1016/j.exer.2015.01.007_bib30 article-title: Changes in refraction, ocular aberrations, and corneal structure after suspending rigid gas-permeable contact lens wear in keratoconus publication-title: Cornea doi: 10.1097/ICO.0b013e31820f777b – volume: 41 start-page: 2997 year: 2011 ident: 10.1016/j.exer.2015.01.007_bib20 article-title: Arginine depletion as a mechanism for the immune privilege of corneal allografts publication-title: Eur. J. Immunol. doi: 10.1002/eji.201141683 – year: 2014 ident: 10.1016/j.exer.2015.01.007_bib53 article-title: Short-term corneal changes with gas-permeable contact lens wear in keratoconus subjects: a comparison of two fitting approaches publication-title: J. Optom. – volume: 92 start-page: 282 year: 2011 ident: 10.1016/j.exer.2015.01.007_bib31 article-title: Differential epithelial and stromal protein profiles in keratoconus and normal human corneas publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2011.01.008 – volume: 82 start-page: 1014 year: 2005 ident: 10.1016/j.exer.2015.01.007_bib67 article-title: Comparison of flat and steep rigid contact lens fitting methods in keratoconus publication-title: Optom. Vis. Sci.: Off. Publ. Am. Acad. Optom. doi: 10.1097/01.opx.0000192349.11525.de – volume: 73 start-page: 729 year: 1996 ident: 10.1016/j.exer.2015.01.007_bib27 article-title: Feasibility of fitting contact lenses with apical clearance in keratoconus publication-title: Optom. Vis. Sci.: Off. Publ. Am. Acad. Optom. doi: 10.1097/00006324-199612000-00002 – volume: 249 start-page: C409 year: 1985 ident: 10.1016/j.exer.2015.01.007_bib58 article-title: Role of glucose in corneal metabolism publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1985.249.5.C409 – volume: 50 start-page: 341 year: 2002 ident: 10.1016/j.exer.2015.01.007_bib14 article-title: Evidence of oxidative stress in human corneal diseases publication-title: J. Histochem. Cytochem. doi: 10.1177/002215540205000306 – volume: 45 start-page: 1916 year: 2004 ident: 10.1016/j.exer.2015.01.007_bib52 article-title: Metabolic changes in rat lens after in vivo exposure to ultraviolet irradiation: measurements by high resolution MAS 1H NMR spectroscopy publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.03-1292 – volume: 22 start-page: 270 year: 1996 ident: 10.1016/j.exer.2015.01.007_bib57 article-title: Influence of contact lens wear on the corneal topography of keratoconus publication-title: CLAO J.: Off. Publ. Contact Lens Assoc. Ophthalmol. Inc. – volume: 13 start-page: 73 year: 1994 ident: 10.1016/j.exer.2015.01.007_bib8 article-title: Recurrent keratoconus publication-title: Cornea doi: 10.1097/00003226-199401000-00012 – year: 1965 ident: 10.1016/j.exer.2015.01.007_bib40 article-title: The regulation of corneal regulation – volume: 30 start-page: 223 year: 2007 ident: 10.1016/j.exer.2015.01.007_bib60 article-title: Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study: methods and findings to date publication-title: Contact Lens Anterior eye: J. Br. Contact Lens Assoc. doi: 10.1016/j.clae.2007.03.001 – volume: 87 start-page: 122 year: 2013 ident: 10.1016/j.exer.2015.01.007_bib15 article-title: The keratoconus corneal proteome: loss of epithelial integrity and stromal degeneration publication-title: J. Proteomics doi: 10.1016/j.jprot.2013.05.023 – volume: 22 start-page: 333 year: 2001 ident: 10.1016/j.exer.2015.01.007_bib17 article-title: Expression of type XII collagen and hemidesmosome-associated proteins in keratoconus corneas publication-title: Curr. Eye Res. doi: 10.1076/ceyr.22.5.333.5491 – volume: 18 start-page: 2 year: 2011 ident: 10.1016/j.exer.2015.01.007_bib50 article-title: The genetics of keratoconus publication-title: Middle East Afr. J. Ophthalmol. doi: 10.4103/0974-9233.75876 – volume: 107 start-page: 105 year: 2000 ident: 10.1016/j.exer.2015.01.007_bib38 article-title: The effects of long-term contact lens wear on corneal thickness, curvature, and surface regularity publication-title: Ophthalmology doi: 10.1016/S0161-6420(99)00027-5 – volume: 24 start-page: 201 year: 2010 ident: 10.1016/j.exer.2015.01.007_bib29 article-title: Effects of multicurve RGP contact lens use on topographic changes in keratoconus publication-title: Korean J. Ophthalmol.: KJO doi: 10.3341/kjo.2010.24.4.201 – volume: 7 start-page: 27 year: 2002 ident: 10.1016/j.exer.2015.01.007_bib37 article-title: Urea cycle disorders publication-title: Semin. Neonatol.: SN doi: 10.1053/siny.2001.0085 – volume: 28 start-page: 40 year: 2002 ident: 10.1016/j.exer.2015.01.007_bib18 article-title: Corneal endothelial polymegethism and pleomorphism induced by daily-wear rigid gas-permeable contact lenses publication-title: CLAO J.: Off. Publ. Contact Lens Assoc. Ophthalmol. Inc. – volume: 12 start-page: 310 year: 1993 ident: 10.1016/j.exer.2015.01.007_bib23 article-title: Corneal aldehyde dehydrogenase, glutathione reductase, and glutathione S-transferase in pathologic corneas publication-title: Cornea doi: 10.1097/00003226-199307000-00006 – volume: vol. 13 year: 1969 ident: 10.1016/j.exer.2015.01.007_bib39 article-title: Methods in Enzymology – volume: 42 start-page: 2293 year: 2001 ident: 10.1016/j.exer.2015.01.007_bib9 article-title: Superoxide dismutase isoenzymes in the normal and diseased human cornea publication-title: Investig. Ophthalmol. Vis. Sci. – volume: 12 start-page: 146 issue: 2 year: 1993 ident: 10.1016/j.exer.2015.01.007_bib24 article-title: Analysis of corneal aldehyde dehydrogenase patterns in pathologic corneas publication-title: Cornea doi: 10.1097/00003226-199303000-00010 – volume: 64 start-page: 698 year: 1987 ident: 10.1016/j.exer.2015.01.007_bib68 article-title: Contact lens fitting relation and visual acuity in keratoconus publication-title: Am. J. Optom. Physiol. Opt. doi: 10.1097/00006324-198709000-00009 – volume: 30 start-page: 189 year: 1985 ident: 10.1016/j.exer.2015.01.007_bib26 article-title: Phosphorus nuclear magnetic resonance and ocular metabolism publication-title: Surv. Ophthalmol. doi: 10.1016/0039-6257(85)90063-3 – year: 2001 ident: 10.1016/j.exer.2015.01.007_bib3 – volume: 8 start-page: 185 year: 2010 ident: 10.1016/j.exer.2015.01.007_bib42 article-title: The tear film and the optical quality of the eye publication-title: Ocul. Surf. doi: 10.1016/S1542-0124(12)70233-1 – volume: 103 start-page: 41 year: 2012 ident: 10.1016/j.exer.2015.01.007_bib55 article-title: Tear fluid small molecular antioxidants profiling shows lowered glutathione in keratoconus publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2012.07.010 – volume: 47 start-page: 289 year: 2013 ident: 10.1016/j.exer.2015.01.007_bib63 article-title: Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2012.11.003 – volume: 310 start-page: 273 year: 1994 ident: 10.1016/j.exer.2015.01.007_bib16 article-title: S-thiolation of individual human neutrophil proteins including actin by stimulation of the respiratory burst: evidence against a role for glutathione disulfide publication-title: Arch. Biochem. Biophys. doi: 10.1006/abbi.1994.1167 – volume: 321 start-page: 49 year: 1981 ident: 10.1016/j.exer.2015.01.007_bib34 article-title: Stromal lactate accumulation can account for corneal oedema osmotically following epithelial hypoxia in the rabbit publication-title: J. Physiol. doi: 10.1113/jphysiol.1981.sp013971 – start-page: 724 year: 2000 ident: 10.1016/j.exer.2015.01.007_bib45 – volume: 5 start-page: 9 year: 2012 ident: 10.1016/j.exer.2015.01.007_bib10 article-title: Oxidative stress and antioxidant defense publication-title: World Allergy Organ. J. doi: 10.1097/WOX.0b013e3182439613 – volume: 24 start-page: 39 year: 2013 ident: 10.1016/j.exer.2015.01.007_bib1 article-title: Metabolomics platforms for genome wide association studies–linking the genome to the metabolome publication-title: Curr. Opin. Biotechnol. doi: 10.1016/j.copbio.2012.10.003 – year: 2002 ident: 10.1016/j.exer.2015.01.007_bib21 – volume: 7 start-page: 872 year: 2012 ident: 10.1016/j.exer.2015.01.007_bib66 article-title: A positive/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue publication-title: Nat. Protoc. doi: 10.1038/nprot.2012.024 – volume: 29 start-page: 1319 year: 2003 ident: 10.1016/j.exer.2015.01.007_bib12 article-title: Effect of contact lens wear on central corneal thickness measurements publication-title: J. Cataract Refract. Surg. doi: 10.1016/S0886-3350(03)00230-X – volume: 201 start-page: 267 year: 1986 ident: 10.1016/j.exer.2015.01.007_bib7 article-title: Organization of citric acid cycle enzymes into a multienzyme cluster publication-title: FEBS Lett. doi: 10.1016/0014-5793(86)80621-4 – volume: 4 start-page: 1247 year: 2012 ident: 10.1016/j.exer.2015.01.007_bib69 article-title: Redox status expressed as GSH: GSSG ratio as a marker for oxidative stress in paediatric tumour patients publication-title: Oncol. Lett. doi: 10.3892/ol.2012.931 – volume: 70 start-page: 317 year: 2007 ident: 10.1016/j.exer.2015.01.007_bib44 article-title: Psychological and social aspects of patients with keratoconus publication-title: Arq. bras. oftalmol. doi: 10.1590/S0004-27492007000200023 – volume: 124A start-page: 28 year: 2004 ident: 10.1016/j.exer.2015.01.007_bib2 article-title: Brittle cornea syndrome and its delineation from the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VI): report on 23 patients and review of the literature publication-title: Am. J. Med. Genet A doi: 10.1002/ajmg.a.20326 – volume: 12 start-page: 1615 year: 2006 ident: 10.1016/j.exer.2015.01.007_bib56 article-title: Molecular changes in selected epithelial proteins in human keratoconus corneas compared to normal corneas publication-title: Mol. Vis. – volume: 91 start-page: 106 year: 2013 ident: 10.1016/j.exer.2015.01.007_bib48 article-title: Update on the keratoconus genetics publication-title: Acta Ophthalmol. doi: 10.1111/j.1755-3768.2012.02400.x – volume: 223 start-page: 877 year: 2006 ident: 10.1016/j.exer.2015.01.007_bib61 article-title: How to live with keratoconus publication-title: Klin. Monbl. Augenheilkd. doi: 10.1055/s-2006-927144 – volume: 28 start-page: 169 year: 2002 ident: 10.1016/j.exer.2015.01.007_bib62 article-title: Time to resolution of contact lens-induced corneal warpage prior to refractive surgery publication-title: CLAO J.: Off. Publ. Contact Lens Assoc. Ophthalmol. Inc. – volume: 82 start-page: 201 year: 2006 ident: 10.1016/j.exer.2015.01.007_bib49 article-title: Proteome profiling of corneal epithelium and identification of marker proteins for keratoconus, a pilot study publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2005.06.009 – volume: 42 start-page: 297 year: 1998 ident: 10.1016/j.exer.2015.01.007_bib51 article-title: Keratoconus publication-title: Surv. Ophthalmol. doi: 10.1016/S0039-6257(97)00119-7 – volume: 33 start-page: 157 year: 2010 ident: 10.1016/j.exer.2015.01.007_bib54 article-title: Keratoconus: a review publication-title: Contact Lens Anterior eye: J. Br. Contact Lens Assoc. doi: 10.1016/j.clae.2010.04.006 – volume: 4 start-page: 4608 year: 2014 ident: 10.1016/j.exer.2015.01.007_bib32 article-title: In vitro model suggests oxidative stress involved in keratoconus disease publication-title: Sci. Rep. doi: 10.1038/srep04608 – volume: 28 start-page: 293 year: 1984 ident: 10.1016/j.exer.2015.01.007_bib35 article-title: Keratoconus and related noninflammatory corneal thinning disorders publication-title: Surv. Ophthalmol. doi: 10.1016/0039-6257(84)90094-8 – volume: 46 start-page: 1256 year: 2005 ident: 10.1016/j.exer.2015.01.007_bib6 article-title: Accumulation of mitochondrial DNA damage in keratoconus corneas publication-title: Investig. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.04-1395 – year: 1983 ident: 10.1016/j.exer.2015.01.007_bib19 article-title: Physiology of the cornea: metabolism and biochemistry – volume: 26 start-page: 10 year: 2000 ident: 10.1016/j.exer.2015.01.007_bib33 article-title: Everett Kinsey lecture. The elusive causes of keratoconus: a working hypothesis publication-title: CLAO J.: Off. Publ. Contact Lens Assoc. Ophthalmol. Inc. – volume: 4 start-page: e1000282 year: 2008 ident: 10.1016/j.exer.2015.01.007_bib22 article-title: Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum publication-title: Plos Genet. doi: 10.1371/journal.pgen.1000282 – volume: 60 start-page: 1 year: 1977 ident: 10.1016/j.exer.2015.01.007_bib65 article-title: Gluconeogenesis in cattle: significance and methodology publication-title: J. Dairy Sci. doi: 10.3168/jds.S0022-0302(77)83821-6 – reference: 6230745 - Surv Ophthalmol. 1984 Jan-Feb;28(4):293-322 – reference: 23268465 - World Allergy Organ J. 2012 Jan;5(1):9-19 – reference: 22498707 - Nat Protoc. 2012 May;7(5):872-81 – reference: 21281627 - Exp Eye Res. 2011 Apr;92(4):282-98 – reference: 16015083 - Cornea. 2005 Aug;24(6):661-8 – reference: 21805470 - Eur J Immunol. 2011 Oct;41(10):2997-3005 – reference: 21572727 - Middle East Afr J Ophthalmol. 2011 Jan;18(1):2-6 – reference: 8500322 - Cornea. 1993 Mar;12(2):146-54 – reference: 9493273 - Surv Ophthalmol. 1998 Jan-Feb;42(4):297-319 – reference: 23207114 - J Psychiatr Res. 2013 Mar;47(3):289-98 – reference: 21969298 - Invest Ophthalmol Vis Sci. 2011;52(12):8592-7 – reference: 24714342 - Sci Rep. 2014;4:4608 – reference: 11838988 - CLAO J. 2002 Jan;28(1):40-3 – reference: 14679583 - Am J Med Genet A. 2004 Jan 1;124A(1):28-34 – reference: 3688191 - Am J Optom Physiol Opt. 1987 Sep;64(9):698-702 – reference: 3933363 - Am J Physiol. 1985 Nov;249(5 Pt 1):C409-16 – reference: 17200661 - Mol Vis. 2006;12:1615-25 – reference: 3863808 - Invest Ophthalmol Vis Sci. 1985 Nov;26(11):1489-501 – reference: 16357642 - Optom Vis Sci. 2005 Dec;82(12):1014-21 – reference: 17131247 - Klin Monbl Augenheilkd. 2006 Nov;223(11):877-88 – reference: 20537579 - Cont Lens Anterior Eye. 2010 Aug;33(4):157-66; quiz 205 – reference: 9002088 - Optom Vis Sci. 1996 Dec;73(12):729-32 – reference: 19043545 - PLoS Genet. 2008 Nov;4(11):e1000282 – reference: 22471291 - Acta Ophthalmol. 2013 Mar;91(2):106-13 – reference: 3086126 - FEBS Lett. 1986 Jun 9;201(2):267-70 – reference: 23102864 - Curr Opin Biotechnol. 2013 Feb;24(1):39-47 – reference: 3909470 - Surv Ophthalmol. 1985 Nov-Dec;30(3):189-202 – reference: 11850437 - J Histochem Cytochem. 2002 Mar;50(3):341-51 – reference: 7712741 - Cornea. 1995 Jan;14(1):77-83 – reference: 8161216 - Arch Biochem Biophys. 1994 Apr;310(1):273-81 – reference: 22960318 - Exp Eye Res. 2012 Oct;103:41-6 – reference: 25199441 - J Optom. 2015 Jan-Mar;8(1):48-55 – reference: 23205122 - Oncol Lett. 2012 Dec;4(6):1247-1253 – reference: 19411974 - Cornea. 2009 May;28(4):477-9 – reference: 17481941 - Cont Lens Anterior Eye. 2007 Sep;30(4):223-32 – reference: 8131410 - Cornea. 1994 Jan;13(1):73-7 – reference: 17157577 - Am J Ophthalmol. 2006 Dec;142(6):923-30 – reference: 7338822 - J Physiol. 1981 Dec;321:49-64 – reference: 8339559 - Cornea. 1993 Jul;12(4):310-4 – reference: 15790887 - Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1256-63 – reference: 20964981 - Ocul Surf. 2010 Oct;8(4):185-92 – reference: 11527942 - Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2293-6 – reference: 8906386 - CLAO J. 1996 Oct;22(4):270-3 – reference: 10647727 - Ophthalmology. 2000 Jan;107(1):105-11 – reference: 16083875 - Exp Eye Res. 2006 Feb;82(2):201-9 – reference: 11600933 - Curr Eye Res. 2001 May;22(5):333-40 – reference: 20714382 - Korean J Ophthalmol. 2010 Aug;24(4):201-6 – reference: 15161858 - Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1916-21 – reference: 320235 - J Dairy Sci. 1977 Jan;60(1):1-15 – reference: 24688685 - Comput Struct Biotechnol J. 2013 Feb 06;4:e201301003 – reference: 22314817 - Cornea. 2012 May;31(5):500-8 – reference: 16799019 - Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2820-2 – reference: 23727491 - J Proteomics. 2013 Jul 11;87:122-31 – reference: 10656302 - CLAO J. 2000 Jan;26(1):10-3 – reference: 17589706 - Arq Bras Oftalmol. 2007 Mar-Apr;70(2):317-22 – reference: 12900239 - J Cataract Refract Surg. 2003 Jul;29(7):1319-22 – reference: 5674798 - Arch Ophthalmol. 1968 Oct;80(4):430-2 – reference: 22410572 - Invest Ophthalmol Vis Sci. 2012 Apr;53(4):2020-9 – reference: 12394539 - CLAO J. 2002 Oct;28(4):169-71 – reference: 12069536 - Semin Neonatol. 2002 Feb;7(1):27-35 |
| SSID | ssj0003474 |
| Score | 2.3908737 |
| Snippet | While efforts have been made over the years, the exact cause of keratoconus (KC) remains unknown. The aim of this study was to identify alterations in... |
| SourceID | pubmedcentral proquest pubmed crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 1 |
| SubjectTerms | Adult Analysis of Variance Case-Control Studies Eye Proteins - metabolism Female Humans Keratoconus - metabolism Male Middle Aged Oxidative Stress - physiology Tandem Mass Spectrometry Tears - metabolism Young Adult |
| Title | Tear metabolite changes in keratoconus |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/25579606 https://www.proquest.com/docview/1661333311 https://pubmed.ncbi.nlm.nih.gov/PMC4436698 |
| Volume | 132 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYlhdJLaZM-ti9cKLkUG8uStfZx6YOl0FyaQG5Glkck28Zbts4hPfS3d0bS-rFNS9OFNUZrC-GZHc-MvvmGsdcZlEqmOo_nBppYWjBxbbSNtUKNThstjXVsn0dqeSI_nuanQ6dCV13S1Yn5cW1dyf9IFcdQrlQlewPJ9pPiAJ6jfPGIEsbjv8mYWHguoENBUilxqOJ1CNcvRJa8xmA3BParHnI3EPrDFfVMGaWzyPDqDXWoP_Pou3dJn1jGiDpwcybD6GdYofvoLddyGCXIzyY-0s6MLJJxZoHnA7Rqay25pGRjPrGWIR3p7R0fvzivtcg-ObBKqIMUIek8S6rvdDulv955LfVgwS0ObVXRHBXNUaW8chwCtzOMDqhxRfJzQPYIGci3w_JDrZSH9e2uY-qP_BZk7GJlR87H8X12L0QN0cKrwAN2C9p9drBoUcQXV9Fh5HC8boNkn935FOASB-yQFCQaFCQKChKdt9FIQR6ykw_vj98u49AYIzYY7nexzsGa2sqU8gtZ0eTAM13WBnLQmRVQq1pI_NKWukX_VqoUAHhqG12KItPiEdtr1y08YZFSeJMoGvIcZQmqoJjAiHlpKTlu0hnj28dTmcAaT81LvlZ_FsuMvenv-eY5U_569avtU6_QtNF-lW5hffm94ug7CvxwPmOPvRT6-TASnlPwPWPziXz6C4g2ffpLe37m6NOlFEqVxdMbrfIZuzv8RZ6zvW5zCS_QHe3ql075fgHQBYjh |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Tear+metabolite+changes+in+keratoconus&rft.jtitle=Experimental+eye+research&rft.au=Karamichos%2C+D.&rft.au=Zieske%2C+J.D.&rft.au=Sejersen%2C+H.&rft.au=Sarker-Nag%2C+A.&rft.date=2015-03-01&rft.issn=0014-4835&rft.volume=132&rft.spage=1&rft.epage=8&rft_id=info:doi/10.1016%2Fj.exer.2015.01.007&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_exer_2015_01_007 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0014-4835&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0014-4835&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0014-4835&client=summon |