Central Benzodiazepine Receptor Binding Potential and CBF Images on SPECT Correlate with Oxygen Extraction Fraction Images on PET in the Cerebral Cortex with Unilateral Major Cerebral Artery Occlusive Disease

• Published in: Journal of Nuclear Medicine Vol. 52; no. 4; pp. 511 - 518
• Main Authors: Chida, Kohei, Ogasawara, Kuniaki, Kuroda, Hiroki, Aso, Kenta, Kobayashi, Masakazu, Fujiwara, Shunrou, Yoshida, Kenji, Terasaki, Kazunori, Ogawa, Akira
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.04.2011
• Subjects: Adult; Aged; Arterial Occlusive Diseases - diagnostic imaging; Arterial Occlusive Diseases - metabolism; Basal Ganglia - diagnostic imaging; Basal Ganglia - metabolism; Brain; Carotid Stenosis - diagnostic imaging; Carotid Stenosis - metabolism; Cerebellum - diagnostic imaging; Cerebellum - metabolism; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - metabolism; Cerebrovascular Circulation - physiology; Disease; Family medical history; Female; Flumazenil - analogs & derivatives; Humans; Image Processing, Computer-Assisted; Infarction, Middle Cerebral Artery - diagnostic imaging; Infarction, Middle Cerebral Artery - metabolism; Intracranial Arterial Diseases - diagnostic imaging; Intracranial Arterial Diseases - metabolism; Iofetamine; Magnetic Resonance Imaging; Male; Medical imaging; Middle Aged; Oxygen Consumption - physiology; Oxygen Radioisotopes; Positron-Emission Tomography - methods; Radiopharmaceuticals; Receptors, GABA-A - metabolism; Tomography, Emission-Computed, Single-Photon - methods; Veins & arteries

Oxygen extraction fraction (OEF) is a key predictor of stroke recurrence in patients with symptomatic major cerebral arterial occlusive disease. The purpose of the present study was to compare central benzodiazepine receptor binding potential (BRBP) and cerebral blood flow (CBF) images on SPECT with...