A multicentric Western analysis of prognostic factors in advanced, node-negative gastric cancer patients

The presence of lymph node metastasis is one of the most important prognostic factors in patients with gastric carcinoma. Node-negative patients have a better outcome, nevertheless a subgroup of them experience disease recurrence. To analyze the clinicopathological characteristics of lymph node-nega...

Full description

Saved in:
Bibliographic Details
Published inAnnals of surgery Vol. 252; no. 1; p. 70
Main Authors Baiocchi, Gian Luca, Tiberio, Guido A, Minicozzi, Anna Maria, Morgagni, Paolo, Marrelli, Daniele, Bruno, Lorenzo, Rosa, Fausto, Marchet, Alberto, Coniglio, Arianna, Saragoni, Luca, Veltri, Marco, Pacelli, Fabio, Roviello, Franco, Nitti, Donato, Giulini, Stefano M, De Manzoni, Giovanni
Format Journal Article
LanguageEnglish
Published United States 01.07.2010
Subjects
Online AccessGet more information

Cover

Loading…
Abstract The presence of lymph node metastasis is one of the most important prognostic factors in patients with gastric carcinoma. Node-negative patients have a better outcome, nevertheless a subgroup of them experience disease recurrence. To analyze the clinicopathological characteristics of lymph node-negative advanced gastric carcinoma patients submitted to gastrectomy and D2 lymphadenectomy with a retrieved number of nodes greater than 15, after an actual follow-up of almost 5 years, and to evaluate outcome indicators. The records of 301 patients who underwent curative gastrectomy for gastric carcinoma and were adequately staged as N0 between 1992 and 2002 were retrospectively analyzed from the prospectively collected database of 7 centers participating to the Italian Research Group for Gastric Cancer. Disease-specific and disease-free survival after 3, 5, and 10 years were 90.4%, 86.1%, 75.9%, and 72.1%, 57.3%, 57.3%, respectively. Mortality was 1.7%. The factors associated with a better disease-free survival at univariate analysis were age <60, T2 tumors, distal location, intestinal histotype, and number of retrieved nodes >25; depth of infiltration and histotype were the only 2 independent predictors of 5-year recurrence-free survival at multivariate analysis. These parameters must be considered to stratify node-negative gastric cancer patients for an adjuvant treatment and follow-up scheduling. Survival was similar to that previously reported by Eastern Centers. Lymphadenectomy is suggested to be effective, and retrieval of more than 25 nodes may be warranted.
AbstractList The presence of lymph node metastasis is one of the most important prognostic factors in patients with gastric carcinoma. Node-negative patients have a better outcome, nevertheless a subgroup of them experience disease recurrence. To analyze the clinicopathological characteristics of lymph node-negative advanced gastric carcinoma patients submitted to gastrectomy and D2 lymphadenectomy with a retrieved number of nodes greater than 15, after an actual follow-up of almost 5 years, and to evaluate outcome indicators. The records of 301 patients who underwent curative gastrectomy for gastric carcinoma and were adequately staged as N0 between 1992 and 2002 were retrospectively analyzed from the prospectively collected database of 7 centers participating to the Italian Research Group for Gastric Cancer. Disease-specific and disease-free survival after 3, 5, and 10 years were 90.4%, 86.1%, 75.9%, and 72.1%, 57.3%, 57.3%, respectively. Mortality was 1.7%. The factors associated with a better disease-free survival at univariate analysis were age <60, T2 tumors, distal location, intestinal histotype, and number of retrieved nodes >25; depth of infiltration and histotype were the only 2 independent predictors of 5-year recurrence-free survival at multivariate analysis. These parameters must be considered to stratify node-negative gastric cancer patients for an adjuvant treatment and follow-up scheduling. Survival was similar to that previously reported by Eastern Centers. Lymphadenectomy is suggested to be effective, and retrieval of more than 25 nodes may be warranted.
Author Morgagni, Paolo
Veltri, Marco
Roviello, Franco
Marchet, Alberto
Tiberio, Guido A
Bruno, Lorenzo
Rosa, Fausto
Coniglio, Arianna
Nitti, Donato
Saragoni, Luca
Pacelli, Fabio
Giulini, Stefano M
De Manzoni, Giovanni
Marrelli, Daniele
Minicozzi, Anna Maria
Baiocchi, Gian Luca
Author_xml – sequence: 1
  givenname: Gian Luca
  surname: Baiocchi
  fullname: Baiocchi, Gian Luca
  email: baiocchi@med.unibs.it
  organization: Department of Medical and Surgical Sciences, Surgical Clinic, Brescia University, Brescia, Italy. baiocchi@med.unibs.it
– sequence: 2
  givenname: Guido A
  surname: Tiberio
  fullname: Tiberio, Guido A
– sequence: 3
  givenname: Anna Maria
  surname: Minicozzi
  fullname: Minicozzi, Anna Maria
– sequence: 4
  givenname: Paolo
  surname: Morgagni
  fullname: Morgagni, Paolo
– sequence: 5
  givenname: Daniele
  surname: Marrelli
  fullname: Marrelli, Daniele
– sequence: 6
  givenname: Lorenzo
  surname: Bruno
  fullname: Bruno, Lorenzo
– sequence: 7
  givenname: Fausto
  surname: Rosa
  fullname: Rosa, Fausto
– sequence: 8
  givenname: Alberto
  surname: Marchet
  fullname: Marchet, Alberto
– sequence: 9
  givenname: Arianna
  surname: Coniglio
  fullname: Coniglio, Arianna
– sequence: 10
  givenname: Luca
  surname: Saragoni
  fullname: Saragoni, Luca
– sequence: 11
  givenname: Marco
  surname: Veltri
  fullname: Veltri, Marco
– sequence: 12
  givenname: Fabio
  surname: Pacelli
  fullname: Pacelli, Fabio
– sequence: 13
  givenname: Franco
  surname: Roviello
  fullname: Roviello, Franco
– sequence: 14
  givenname: Donato
  surname: Nitti
  fullname: Nitti, Donato
– sequence: 15
  givenname: Stefano M
  surname: Giulini
  fullname: Giulini, Stefano M
– sequence: 16
  givenname: Giovanni
  surname: De Manzoni
  fullname: De Manzoni, Giovanni
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20562605$$D View this record in MEDLINE/PubMed
BookMark eNo1j9tKAzEURYMo9qJ_IJIPcOpJMplJHkuxKhR8UXwsuZzUkWlmSKaF_r3j7WnD3osFe0bOYxeRkBsGCwa6vs-tWYAFJlAwxbCUSuIZmTLJVcFYCRMyy_kTgJUK6ksy4SArXoGcko8l3R_aoXEYh9Q4-o55wBSpiaY95SbTLtA-dbvY5RGiwbihS5k2I-GPJjr0dzR2HouIOzM0R6Q7k39M7ntNtB_b0Z2vyEUwbcbrv5yTt_XD6-qp2Lw8Pq-Wm8KVwIdCa6uUD1wAN1pZp2sXUCkhg_WV584Giyg9WCVrJ4TQbHyiJJhaaKUD8jm5_fX2B7tHv-1TszfptP2_zL8AENNcnA
CitedBy_id crossref_primary_10_1007_s13304_011_0065_8
crossref_primary_10_1016_j_gassur_2024_05_031
crossref_primary_10_1093_annonc_mdr284
crossref_primary_10_1245_s10434_015_5075_1
crossref_primary_10_1016_j_ejso_2011_01_013
crossref_primary_10_1371_journal_pone_0105112
crossref_primary_10_1097_MD_0000000000004420
crossref_primary_10_1186_1477_7819_9_48
crossref_primary_10_1186_1471_2407_13_281
crossref_primary_10_1007_s00595_015_1127_1
crossref_primary_10_1245_s10434_020_08387_9
crossref_primary_10_1007_s13304_018_0537_1
crossref_primary_10_1002_jso_22089
crossref_primary_10_18632_oncotarget_9041
crossref_primary_10_3748_wjg_v20_i34_11966
crossref_primary_10_1245_s10434_016_5513_8
crossref_primary_10_3390_curroncol30010067
crossref_primary_10_1007_s00423_014_1226_2
crossref_primary_10_4251_wjgo_v14_i8_1406
crossref_primary_10_1007_s10120_014_0362_2
crossref_primary_10_1007_s11605_015_2994_x
crossref_primary_10_12998_wjcc_v11_i9_1930
crossref_primary_10_1007_s11605_012_1881_y
crossref_primary_10_1155_2014_603194
crossref_primary_10_1200_JCO_2010_34_4358
crossref_primary_10_2478_arsm_2020_0007
crossref_primary_10_1097_MEG_0000000000000307
crossref_primary_10_1245_s10434_014_4078_7
crossref_primary_10_4174_astr_2014_87_4_180
crossref_primary_10_1186_s12957_015_0613_7
crossref_primary_10_3892_mco_2016_804
crossref_primary_10_1245_s10434_016_5667_4
crossref_primary_10_1186_s12957_023_03146_y
crossref_primary_10_1007_s10120_011_0052_2
crossref_primary_10_1007_s10120_014_0443_2
crossref_primary_10_1097_SLA_0000000000001332
crossref_primary_10_1038_s41598_021_83386_8
crossref_primary_10_1245_s10434_015_4578_0
crossref_primary_10_1177_1457496916677878
crossref_primary_10_3389_fonc_2018_00275
crossref_primary_10_1007_s00268_011_1351_9
crossref_primary_10_1007_s13304_020_00757_y
crossref_primary_10_1007_s13304_023_01727_w
crossref_primary_10_12659_MSM_893856
crossref_primary_10_1097_MD_0000000000000620
crossref_primary_10_1245_s10434_014_3534_8
crossref_primary_10_18632_oncotarget_11035
crossref_primary_10_30944_20117582_2484
crossref_primary_10_1371_journal_pone_0038681
crossref_primary_10_1111_ans_12365
crossref_primary_10_17235_reed_2018_5829_2018
crossref_primary_10_1245_s10434_014_4333_y
crossref_primary_10_1016_j_ejso_2013_07_183
crossref_primary_10_1038_srep26313
crossref_primary_10_1590_0102_672020210001e1562
crossref_primary_10_1245_s10434_015_4980_7
crossref_primary_10_1007_s10120_014_0418_3
crossref_primary_10_1016_j_ijsu_2017_11_036
crossref_primary_10_1186_s12957_015_0602_x
crossref_primary_10_1245_s10434_016_5494_7
crossref_primary_10_1245_s10434_021_09625_4
crossref_primary_10_5230_jgc_2017_17_e35
crossref_primary_10_1245_s10434_012_2852_y
crossref_primary_10_1097_SLA_0b013e3182389b1a
crossref_primary_10_1016_j_jss_2020_05_058
crossref_primary_10_5230_jgc_2014_14_2_111
crossref_primary_10_1007_s13277_010_0142_5
crossref_primary_10_1007_s13304_014_0248_1
crossref_primary_10_1007_s10120_012_0195_9
crossref_primary_10_3748_wjg_v23_i45_8000
crossref_primary_10_1002_jso_25220
crossref_primary_10_1016_j_ejso_2012_10_008
crossref_primary_10_1097_SLA_0b013e318235dfda
crossref_primary_10_1111_jgh_13306
crossref_primary_10_12998_wjcc_v7_i2_145
crossref_primary_10_1007_s00595_017_1611_x
crossref_primary_10_1097_SLA_0000000000001084
crossref_primary_10_1186_s12885_019_5416_8
crossref_primary_10_1159_000376550
crossref_primary_10_1245_s10434_012_2254_1
crossref_primary_10_1016_j_ejso_2017_09_008
crossref_primary_10_1093_jjco_hyv159
crossref_primary_10_3233_CBM_181526
crossref_primary_10_5144_0256_4947_2021_336
crossref_primary_10_1080_14737140_2017_1301207
crossref_primary_10_1371_journal_pone_0074402
crossref_primary_10_1186_s12885_017_3544_6
crossref_primary_10_1371_journal_pone_0101061
crossref_primary_10_1016_j_dld_2016_04_010
crossref_primary_10_1245_s10434_021_10803_7
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
DOI 10.1097/sla.0b013e3181e4585e
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod no_fulltext_linktorsrc
EISSN 1528-1140
ExternalDocumentID 20562605
Genre Multicenter Study
Journal Article
GeographicLocations Italy
GeographicLocations_xml – name: Italy
GroupedDBID ---
.-D
.3C
.55
.GJ
.XZ
.Z2
01R
0R~
1J1
23M
2WC
354
3O-
40H
4Q1
4Q2
4Q3
53G
5GY
5VS
6J9
71W
77Y
7O~
AAAAV
AAAXR
AAEJM
AAGIX
AAHPQ
AAIQE
AAJCS
AAMOA
AAMTA
AAQKA
AARTV
AASCR
AASOK
AASXQ
AAUEB
AAXQO
ABASU
ABBUW
ABDIG
ABJNI
ABOCM
ABPMR
ABPPZ
ABVCZ
ABXVJ
ABZAD
ACCJW
ACDDN
ACEWG
ACGFO
ACGFS
ACILI
ACLDA
ACOAL
ACRZS
ACWDW
ACWRI
ACXJB
ACXNZ
ADBBV
ADFPA
ADGGA
ADHPY
ADNKB
AE3
AE6
AEBDS
AEETU
AENEX
AFCHL
AFDTB
AFEXH
AFSOK
AFUWQ
AGINI
AHJKT
AHOMT
AHQNM
AHRYX
AHVBC
AI.
AIJEX
AINUH
AJIOK
AJJEV
AJNWD
AJNYG
AJZMW
AKULP
ALMA_UNASSIGNED_HOLDINGS
ALMTX
AMJPA
AMKUR
AMNEI
AOHHW
ASPBG
AVWKF
AWKKM
AZFZN
BAWUL
BOYCO
BQLVK
BS7
BYPQX
C45
CGR
CS3
CUY
CVF
DIK
DIWNM
DUNZO
E.X
E3Z
EBS
ECM
EEVPB
EIF
EJD
ERAAH
EX3
F2K
F2L
F2M
F2N
F5P
FCALG
FEDTE
FL-
FW0
GNXGY
GQDEL
H0~
HLJTE
HVGLF
HZ~
IH2
IKREB
IKYAY
IN~
IPNFZ
J5H
JF7
JF9
JG8
JK3
JK8
K-A
K-F
K8S
KD2
KMI
L-C
L7B
M18
N4W
N9A
NPM
N~7
N~B
N~M
O9-
OAG
OAH
OBH
OCB
OCUKA
ODA
ODMTH
OGEVE
OHH
OHYEH
OJAPA
OK1
OL1
OLB
OLG
OLH
OLU
OLV
OLW
OLY
OLZ
OPUJH
ORVUJ
OUVQU
OVD
OVDNE
OVIDH
OVLEI
OVOZU
OWBYB
OWU
OWV
OWW
OWX
OWY
OWZ
OXXIT
P-K
P2P
R58
RIG
RLZ
RPM
RXW
S4R
S4S
T8P
TAF
TEORI
TR2
TSPGW
UQX
V2I
VH1
VVN
W3M
WH7
WOQ
WOW
X3V
X3W
X7M
XXN
XYM
YFH
YOC
ZFV
ZGI
ZXP
ZY1
ZZMQN
~H1
ID FETCH-LOGICAL-c402t-99b88df2302a98bc97cfe8835fbd6d2cbfbee5d0b857c33391562850a73989fe2
IngestDate Tue Oct 15 23:40:50 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c402t-99b88df2302a98bc97cfe8835fbd6d2cbfbee5d0b857c33391562850a73989fe2
PMID 20562605
ParticipantIDs pubmed_primary_20562605
PublicationCentury 2000
PublicationDate 2010-07-01
PublicationDateYYYYMMDD 2010-07-01
PublicationDate_xml – month: 07
  year: 2010
  text: 2010-07-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Annals of surgery
PublicationTitleAlternate Ann Surg
PublicationYear 2010
References 22042478 - Ann Surg. 2011 Nov;254(5):834-5; author reply 835
References_xml
SSID ssj0014807
Score 2.403633
Snippet The presence of lymph node metastasis is one of the most important prognostic factors in patients with gastric carcinoma. Node-negative patients have a better...
SourceID pubmed
SourceType Index Database
StartPage 70
SubjectTerms Adult
Aged
Aged, 80 and over
Disease-Free Survival
Female
Gastrectomy
Humans
Italy - epidemiology
Lymph Node Excision
Lymph Nodes - pathology
Lymphatic Metastasis - pathology
Male
Middle Aged
Prognosis
Retrospective Studies
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Title A multicentric Western analysis of prognostic factors in advanced, node-negative gastric cancer patients
URI https://www.ncbi.nlm.nih.gov/pubmed/20562605
Volume 252
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3BTtwwELWW9tILAlFaKCAfetuGZr1JbB9XqIAQy2lRuaHYsZccSFbs7mV_pT_LjO1sUqAqcImiOLEiz8tkZjzzhpDvWsFvP7EA3tjoKLGZiPIB55FlMrYaTmNHVj2-ys6vk4ub9KbX-9PJWlou1LFevVhX8h6pwjWQK1bJvkGy60nhApyDfOEIEobjq2Q88vmALsGy1P3fnvWgn3eIRjD_qqqRjHndWqes1jv_uMBVXZioMlPPAD7N524ujeMPDe3qvGvDtpzL805NtYuGlrXWrktw_wwVx-WyTQSaYGpK6QKzZ8uyqNsg6hhrM-vVqvQJllWOBUTl-sExNp6aus5TYO-Cru4GKnCPnTeBChOUKwOPdeDpmRrty1L2DGZel_qGIs9UvKcOhu-ljeEOTAJej-neDoKa3TuxMzTxMlfb_Z_RJ8TbzdAG2eACu4JcYSAobFBhJX5TiSn5z5deB3mmwxRPfBZnu0y2yGZwOujII2ib9Ey1Q-5GtIseGtBDG_TQ2tIWPTSgh5ZwR0DPD_oXdmjADvXYoQ12PpPr01-Tk_Mo9N2IdBKzRSSlEqKw4JyyXAqlJdfWCDDVrSqygmlllTFpESuRcj0cYosBLMSNcz6UQlrDdsmHqq7MV0JFZjj8IRJQ8zwxOpc6teBxx0U6sEKxbI988QtzO_PkKrfNku3_c-Qb-dTC64B8tIB5cwim4UIdOSE9AvaMZ1I
link.rule.ids 780
linkProvider National Library of Medicine
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+multicentric+Western+analysis+of+prognostic+factors+in+advanced%2C+node-negative+gastric+cancer+patients&rft.jtitle=Annals+of+surgery&rft.au=Baiocchi%2C+Gian+Luca&rft.au=Tiberio%2C+Guido+A&rft.au=Minicozzi%2C+Anna+Maria&rft.au=Morgagni%2C+Paolo&rft.date=2010-07-01&rft.eissn=1528-1140&rft.volume=252&rft.issue=1&rft.spage=70&rft_id=info:doi/10.1097%2Fsla.0b013e3181e4585e&rft_id=info%3Apmid%2F20562605&rft_id=info%3Apmid%2F20562605&rft.externalDocID=20562605