Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis
Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal diseases that threaten the health of an increasing number of individuals as their lifestyles become westernized. New insights have been discovered with the development of various omics techniques, revealing tha...
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| Published in | Cell host & microbe Vol. 30; no. 3; pp. 289 - 300 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
09.03.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal diseases that threaten the health of an increasing number of individuals as their lifestyles become westernized. New insights have been discovered with the development of various omics techniques, revealing that gut-microbiota-derived metabolites play important roles in maintaining intestinal homeostasis and modulating the progression of intestinal diseases from both metabolic and immunological perspectives. Clinical metagenomic and metabolomic studies have revealed links between microbial bile acid (BA) metabolism and IBD and CRC progression. Several BA-derived metabolites were recently been demonstrated to play a role in intestinal immunity, providing fresh insights into how BAs affect the course of IBD and CRC. In this review, we discuss recent studies on the involvement of gut microbiota-derived BAs in intestinal immunity, inflammation, and tumorigenesis along with human omics data to provide prospective insights into future prevention and treatment of IBD and CRC. |
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| AbstractList | Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal diseases that threaten the health of an increasing number of individuals as their lifestyles become westernized. New insights have been discovered with the development of various omics techniques, revealing that gut-microbiota-derived metabolites play important roles in maintaining intestinal homeostasis and modulating the progression of intestinal diseases from both metabolic and immunological perspectives. Clinical metagenomic and metabolomic studies have revealed links between microbial bile acid (BA) metabolism and IBD and CRC progression. Several BA-derived metabolites were recently been demonstrated to play a role in intestinal immunity, providing fresh insights into how BAs affect the course of IBD and CRC. In this review, we discuss recent studies on the involvement of gut microbiota-derived BAs in intestinal immunity, inflammation, and tumorigenesis along with human omics data to provide prospective insights into future prevention and treatment of IBD and CRC. Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal diseases that threaten the health of an increasing number of individuals as their lifestyles become westernized. New insights have been discovered with the development of various omics techniques, revealing that gut-microbiota-derived metabolites play important roles in maintaining intestinal homeostasis and modulating the progression of intestinal diseases from both metabolic and immunological perspectives. Clinical metagenomic and metabolomic studies have revealed links between microbial bile acid (BA) metabolism and IBD and CRC progression. Several BA-derived metabolites were recently been demonstrated to play a role in intestinal immunity, providing fresh insights into how BAs affect the course of IBD and CRC. In this review, we discuss recent studies on the involvement of gut microbiota-derived BAs in intestinal immunity, inflammation, and tumorigenesis along with human omics data to provide prospective insights into future prevention and treatment of IBD and CRC.Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal diseases that threaten the health of an increasing number of individuals as their lifestyles become westernized. New insights have been discovered with the development of various omics techniques, revealing that gut-microbiota-derived metabolites play important roles in maintaining intestinal homeostasis and modulating the progression of intestinal diseases from both metabolic and immunological perspectives. Clinical metagenomic and metabolomic studies have revealed links between microbial bile acid (BA) metabolism and IBD and CRC progression. Several BA-derived metabolites were recently been demonstrated to play a role in intestinal immunity, providing fresh insights into how BAs affect the course of IBD and CRC. In this review, we discuss recent studies on the involvement of gut microbiota-derived BAs in intestinal immunity, inflammation, and tumorigenesis along with human omics data to provide prospective insights into future prevention and treatment of IBD and CRC. Inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are heterogeneous intestinal diseases that threaten the health of an increasing number of individuals as their lifestyles become Westernized. New insights have been discovered with the development of various omics techniques, revealing that gut microbiota-derived metabolites play important roles in maintaining intestinal homeostasis and modulating the progression of intestinal diseases from both metabolic and immunological perspectives. Clinical metagenomic and metabolomic studies revealed a link between microbial bile acid (BA) metabolism, IBD and CRC progression. Several BA-derived metabolites have recently been demonstrated to play a role in intestinal immunity, providing fresh insights into how BAs affect the course of IBD and CRC. In this review, recent studies on the involvement of gut microbiota-derived BAs in intestinal immunity, inflammation and tumorigenesis are discussed, together with human omics data to provide prospective insights into future prevention and therapy of IBD and CRC. Cai et al. reviews recent studies that reveal novel mechanistic links between gut microbiota-derived bile acids and host immunity, intestinal inflammation, and tumorigenesis. Bile acid-related human omics data are summarized and bile acid-targeted therapeutics for the prevention and treatment of inflammatory bowel disease and colorectal cancer are discussed. |
| Author | Cai, Jie Sun, Lulu Gonzalez, Frank J. |
| Author_xml | – sequence: 1 givenname: Jie surname: Cai fullname: Cai, Jie – sequence: 2 givenname: Lulu surname: Sun fullname: Sun, Lulu – sequence: 3 givenname: Frank J. surname: Gonzalez fullname: Gonzalez, Frank J. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35271802$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/s41575-019-0258-z 10.1038/s41586-019-1865-0 10.3748/wjg.14.5630 10.1038/s41591-019-0406-6 10.1016/j.jcmgh.2016.06.004 10.1053/j.gastro.2018.08.022 10.1016/j.chom.2020.01.021 10.1038/nature12726 10.1038/s41579-019-0213-6 10.1016/0039-128X(94)90062-0 10.3390/microorganisms9030469 10.1053/jhep.2003.50116 10.1016/j.ejim.2017.06.020 10.1016/j.cell.2021.12.035 10.1126/science.aaa9420 10.1007/s12010-009-8738-1 10.1099/00207713-50-3-971 10.1039/C8FO01143E 10.1038/s41591-019-0458-7 10.1080/19490976.2020.1819155 10.1016/0005-2760(89)90272-5 10.4315/0362-028X-67.12.2772 10.1017/S0007114517001106 10.1038/s41586-020-2047-9 10.1002/cam4.1965 10.1186/s40168-019-0628-3 10.1016/0005-2760(78)90060-7 10.1371/journal.pone.0006386 10.1128/aem.63.3.1185-1188.1997 10.1080/19490976.2020.1748261 10.1038/nchembio.1864 10.1016/j.immuni.2014.05.013 10.1038/nm.4086 10.1016/j.cell.2017.05.016 10.1038/s41586-020-2396-4 10.3322/caac.21601 10.1136/gut.39.4.587 10.1099/00207713-51-1-39 10.1016/j.resmic.2006.04.002 10.1371/journal.pone.0085344 10.1128/AEM.66.6.2502-2512.2000 10.1016/j.immuni.2017.11.012 10.1080/19490976.2021.1907271 10.1038/s41586-019-1237-9 10.1146/annurev-immunol-061020-053702 10.1073/pnas.0509592103 10.1038/nrgastro.2016.165 10.1038/nature11225 10.1128/AEM.00235-18 10.1080/19490976.2015.1127483 10.1016/j.immuni.2018.01.007 10.1021/acschembio.1c00192 10.1002/cncr.28799 10.1016/S0021-9258(18)99213-6 10.1016/j.jhep.2012.01.019 10.1002/cphy.c120023 10.1038/nm.4185 10.1002/cphy.c120007 10.3390/pathogens3010014 10.1136/gut.2010.212159 10.1093/jnci/djz166 10.1016/j.chom.2021.07.013 10.1038/ncomms3384 10.1021/acscentsci.9b00147 10.1194/jlr.M075143 10.1073/pnas.0804437105 10.1016/0005-2736(80)90075-9 10.1016/S0140-6736(03)12489-0 10.1016/j.chom.2021.06.019 10.1053/j.gastro.2011.07.046 10.1093/jnci/djt300 10.1053/jhep.2000.7877 10.1016/S0022-2275(20)41573-1 10.1016/j.crohns.2013.09.009 10.1038/s41420-021-00589-8 10.7554/eLife.37182 10.1038/s41586-021-03421-6 10.1038/nri.2016.42 10.1016/j.femsre.2004.09.003 10.1038/nrgastro.2017.119 10.1038/s41577-021-00534-x 10.1053/j.gastro.2011.10.001 10.1038/s41586-019-1785-z 10.1016/0005-2744(76)90068-1 10.3748/wjg.v18.i21.2609 10.1194/jlr.R500013-JLR200 10.1016/j.cmet.2013.01.003 10.1099/00221287-147-12-3403 10.1002/mc.22999 10.1136/gut.48.2.206 10.1128/aem.61.7.2514-2520.1995 10.1038/s41564-018-0306-4 10.1053/j.gastro.2020.05.067 10.1038/cr.2016.151 10.1016/j.ebiom.2020.102719 10.1371/journal.pone.0070803 10.1093/ecco-jcc/jjab003 10.1016/0005-2760(76)90086-2 10.1016/j.immuni.2016.09.008 10.1038/nri.2016.36 10.1038/s41575-020-00404-2 10.1016/j.mam.2017.04.002 10.1128/aem.37.5.992-1000.1979 10.1007/s10620-020-06208-3 10.1038/nri3073 10.1038/s41589-020-0467-3 10.1038/s41586-021-03832-5 10.1038/s41586-020-2193-0 10.1038/nrgastro.2015.150 |
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| References | Li (10.1016/j.chom.2022.02.004_bib61) 2021; 29 Jia (10.1016/j.chom.2022.02.004_bib46) 2018; 15 Coleman (10.1016/j.chom.2022.02.004_bib14) 1980; 599 Wijaya (10.1016/j.chom.2022.02.004_bib104) 2004; 67 Kumar (10.1016/j.chom.2022.02.004_bib57) 2018; 48 O’Keefe (10.1016/j.chom.2022.02.004_bib72) 2016; 13 Huttenhower (10.1016/j.chom.2022.02.004_bib40) 2014; 40 Sato (10.1016/j.chom.2022.02.004_bib81) 2021; 599 Song (10.1016/j.chom.2022.02.004_bib91) 2020; 577 Pearson (10.1016/j.chom.2022.02.004_bib75) 2019; 8 Wang (10.1016/j.chom.2022.02.004_bib100) 2020; 12 Zhang (10.1016/j.chom.2022.02.004_bib110) 2021; 7 Tanaka (10.1016/j.chom.2022.02.004_bib96) 2000; 66 Gonzalez (10.1016/j.chom.2022.02.004_bib34) 2012; 2 Schirmer (10.1016/j.chom.2022.02.004_bib83) 2019; 17 Doden (10.1016/j.chom.2022.02.004_bib19) 2018; 84 Begley (10.1016/j.chom.2022.02.004_bib6) 2005; 29 Lorenzo-Zúñiga (10.1016/j.chom.2022.02.004_bib64) 2003; 37 Tanoue (10.1016/j.chom.2022.02.004_bib97) 2016; 16 Hang (10.1016/j.chom.2022.02.004_bib37) 2019; 576 Quinn (10.1016/j.chom.2022.02.004_bib76) 2020; 579 Jones (10.1016/j.chom.2022.02.004_bib50) 2008; 105 Harris (10.1016/j.chom.2022.02.004_bib39) 2018; 9 Li (10.1016/j.chom.2022.02.004_bib60) 2013; 4 Patel (10.1016/j.chom.2022.02.004_bib74) 2010; 162 Doden (10.1016/j.chom.2022.02.004_bib20) 2021; 13 Killenberg (10.1016/j.chom.2022.02.004_bib52) 1978; 19 Sefik (10.1016/j.chom.2022.02.004_bib86) 2015; 349 Macdonald (10.1016/j.chom.2022.02.004_bib65) 1976; 450 Fouts (10.1016/j.chom.2022.02.004_bib26) 2012; 56 Jin (10.1016/j.chom.2022.02.004_bib48) 2022; 185 Parasar (10.1016/j.chom.2022.02.004_bib73) 2019; 5 Gadaleta (10.1016/j.chom.2022.02.004_bib32) 2020; 54 Kishinaka (10.1016/j.chom.2022.02.004_bib53) 1994; 59 Jansson (10.1016/j.chom.2022.02.004_bib45) 2009; 4 Edenharder (10.1016/j.chom.2022.02.004_bib23) 1989; 1004 Sayin (10.1016/j.chom.2022.02.004_bib82) 2013; 17 Kitahara (10.1016/j.chom.2022.02.004_bib54) 2000; 50 Schroeder (10.1016/j.chom.2022.02.004_bib85) 2016; 22 Kitahara (10.1016/j.chom.2022.02.004_bib55) 2001; 51 Coleman (10.1016/j.chom.2022.02.004_bib13) 1995; 61 Martinez-Augustin (10.1016/j.chom.2022.02.004_bib67) 2008; 14 Cross (10.1016/j.chom.2022.02.004_bib15) 2014; 120 Wigg (10.1016/j.chom.2022.02.004_bib103) 2001; 48 Gadaleta (10.1016/j.chom.2022.02.004_bib31) 2017; 56 Saito (10.1016/j.chom.2022.02.004_bib80) 2016; 22 Wang (10.1016/j.chom.2022.02.004_bib99) 2019; 58 Smith (10.1016/j.chom.2022.02.004_bib89) 2014; 9 Clements (10.1016/j.chom.2022.02.004_bib12) 1996; 39 Nusse (10.1016/j.chom.2022.02.004_bib71) 2017; 169 Stellwag (10.1016/j.chom.2022.02.004_bib93) 1976; 452 Murray (10.1016/j.chom.2022.02.004_bib70) 2011; 11 Wirbel (10.1016/j.chom.2022.02.004_bib105) 2019; 25 Guo (10.1016/j.chom.2022.02.004_bib36) 2016; 45 Arpaia (10.1016/j.chom.2022.02.004_bib4) 2013; 504 Islam (10.1016/j.chom.2022.02.004_bib43) 2011; 141 Elkins (10.1016/j.chom.2022.02.004_bib24) 2001; 147 Yachida (10.1016/j.chom.2022.02.004_bib108) 2019; 25 Doden (10.1016/j.chom.2022.02.004_bib18) 2021; 9 Gadaleta (10.1016/j.chom.2022.02.004_bib30) 2011; 60 Ilan (10.1016/j.chom.2022.02.004_bib41) 2012; 18 Lavelle (10.1016/j.chom.2022.02.004_bib58) 2020; 17 Kühn (10.1016/j.chom.2022.02.004_bib56) 2020; 112 Ahn (10.1016/j.chom.2022.02.004_bib3) 2013; 105 Floreani (10.1016/j.chom.2022.02.004_bib25) 2018; 47 Lee (10.1016/j.chom.2022.02.004_bib59) 2021; 29 Song (10.1016/j.chom.2022.02.004_bib90) 2019; 7 Chiang (10.1016/j.chom.2022.02.004_bib11) 2013; 3 Cao (10.1016/j.chom.2022.02.004_bib9) 2017; 47 Taranto (10.1016/j.chom.2022.02.004_bib98) 2006; 157 Funabashi (10.1016/j.chom.2022.02.004_bib29) 2020; 582 Yao (10.1016/j.chom.2022.02.004_bib109) 2018; 7 Adhikari (10.1016/j.chom.2022.02.004_bib2) 2021; 16 Sun (10.1016/j.chom.2022.02.004_bib94) 2021; 18 MacDonald (10.1016/j.chom.2022.02.004_bib66) 1979; 37 Ridlon (10.1016/j.chom.2022.02.004_bib77) 2006; 47 Mulder (10.1016/j.chom.2022.02.004_bib69) 2014; 8 Dong (10.1016/j.chom.2022.02.004_bib22) 2021; 39 Watanabe (10.1016/j.chom.2022.02.004_bib101) 2017; 58 Sinha (10.1016/j.chom.2022.02.004_bib88) 2020; 27 Gérard (10.1016/j.chom.2022.02.004_bib33) 2013; 3 Brown (10.1016/j.chom.2022.02.004_bib7) 2017; 117 Sorrentino (10.1016/j.chom.2022.02.004_bib92) 2020; 159 Adhikari (10.1016/j.chom.2022.02.004_bib1) 2020; 16 Molodecky (10.1016/j.chom.2022.02.004_bib68) 2012; 142 Harris (10.1016/j.chom.2022.02.004_bib38) 1978; 528 Friedman (10.1016/j.chom.2022.02.004_bib28) 2018; 155 Siegel (10.1016/j.chom.2022.02.004_bib87) 2020; 70 Franzosa (10.1016/j.chom.2022.02.004_bib27) 2019; 4 Inagaki (10.1016/j.chom.2022.02.004_bib42) 2006; 103 Devkota (10.1016/j.chom.2022.02.004_bib16) 2012; 487 Schmitt (10.1016/j.chom.2022.02.004_bib84) 2021; 21 Campbell (10.1016/j.chom.2022.02.004_bib8) 2020; 581 Axelson (10.1016/j.chom.2022.02.004_bib5) 2000; 31 Guarner (10.1016/j.chom.2022.02.004_bib35) 2003; 361 Tanaka (10.1016/j.chom.2022.02.004_bib95) 2017; 27 Weir (10.1016/j.chom.2022.02.004_bib102) 2013; 8 Doerner (10.1016/j.chom.2022.02.004_bib21) 1997; 63 Johnson (10.1016/j.chom.2022.02.004_bib49) 1991; 266 Ridlon (10.1016/j.chom.2022.02.004_bib78) 2016; 7 Jia (10.1016/j.chom.2022.02.004_bib47) 2020; 11 Chen (10.1016/j.chom.2022.02.004_bib10) 2021; 593 Rooks (10.1016/j.chom.2022.02.004_bib79) 2016; 16 Devlin (10.1016/j.chom.2022.02.004_bib17) 2015; 11 Jacobs (10.1016/j.chom.2022.02.004_bib44) 2016; 2 Liu (10.1016/j.chom.2022.02.004_bib62) 2018; 9 Kaplan (10.1016/j.chom.2022.02.004_bib51) 2015; 12 Xu (10.1016/j.chom.2022.02.004_bib107) 2021; 15 Xu (10.1016/j.chom.2022.02.004_bib106) 2021; 66 Lloyd-Price (10.1016/j.chom.2022.02.004_bib63) 2019; 569 |
| References_xml | – volume: 17 start-page: 223 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib58 article-title: Gut microbiota-derived metabolites as key actors in inflammatory bowel disease publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-019-0258-z – volume: 577 start-page: 410 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib91 article-title: Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis publication-title: Nature doi: 10.1038/s41586-019-1865-0 – volume: 14 start-page: 5630 year: 2008 ident: 10.1016/j.chom.2022.02.004_bib67 article-title: Intestinal bile acid physiology and pathophysiology publication-title: World J. Gastroenterol. doi: 10.3748/wjg.14.5630 – volume: 25 start-page: 679 year: 2019 ident: 10.1016/j.chom.2022.02.004_bib105 article-title: Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer publication-title: Nat. Med. doi: 10.1038/s41591-019-0406-6 – volume: 2 start-page: 750 year: 2016 ident: 10.1016/j.chom.2022.02.004_bib44 article-title: A disease-associated microbial and metabolomics state in relatives of pediatric inflammatory bowel disease patients publication-title: Cell. Mol. Gastroenterol. Hepatol. doi: 10.1016/j.jcmgh.2016.06.004 – volume: 155 start-page: 1741 year: 2018 ident: 10.1016/j.chom.2022.02.004_bib28 article-title: FXR-dependent modulation of the human small Intestinal microbiome by the bBile acid derivative obeticholic acid publication-title: Gastroenterology doi: 10.1053/j.gastro.2018.08.022 – volume: 27 start-page: 659 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib88 article-title: Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation publication-title: Cell Host Microbe doi: 10.1016/j.chom.2020.01.021 – volume: 504 start-page: 451 year: 2013 ident: 10.1016/j.chom.2022.02.004_bib4 article-title: Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation publication-title: Nature doi: 10.1038/nature12726 – volume: 17 start-page: 497 year: 2019 ident: 10.1016/j.chom.2022.02.004_bib83 article-title: Microbial genes and pathways in inflammatory bowel disease publication-title: Nat. Rev. Microbiol. doi: 10.1038/s41579-019-0213-6 – volume: 59 start-page: 485 year: 1994 ident: 10.1016/j.chom.2022.02.004_bib53 article-title: High concentrations of conjugated bile acids inhibit bacterial growth of Clostridium perfringens and induce its extracellular cholylglycine hydrolase publication-title: Steroids doi: 10.1016/0039-128X(94)90062-0 – volume: 9 start-page: 469 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib18 article-title: Microbial hydroxysteroid dehydrogenases: From α to omega publication-title: Microorganisms doi: 10.3390/microorganisms9030469 – volume: 37 start-page: 551 year: 2003 ident: 10.1016/j.chom.2022.02.004_bib64 article-title: Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats publication-title: Hepatology doi: 10.1053/jhep.2003.50116 – volume: 47 start-page: 1 year: 2018 ident: 10.1016/j.chom.2022.02.004_bib25 article-title: Primary biliary cholangitis: Old and novel therapy publication-title: Eur. J. Intern. Med. doi: 10.1016/j.ejim.2017.06.020 – volume: 185 start-page: 547 year: 2022 ident: 10.1016/j.chom.2022.02.004_bib48 article-title: Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome publication-title: Cell doi: 10.1016/j.cell.2021.12.035 – volume: 349 start-page: 993 year: 2015 ident: 10.1016/j.chom.2022.02.004_bib86 article-title: MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells publication-title: Science doi: 10.1126/science.aaa9420 – volume: 162 start-page: 166 year: 2010 ident: 10.1016/j.chom.2022.02.004_bib74 article-title: Probiotic bile salt hydrolase: current developments and perspectives publication-title: Appl. Biochem. Biotechnol. doi: 10.1007/s12010-009-8738-1 – volume: 50 start-page: 971 year: 2000 ident: 10.1016/j.chom.2022.02.004_bib54 article-title: Assignment of Eubacterium sp. VPI 12708 and related strains with high bile acid 7α-dehydroxylating activity to Clostridium scindens and proposal of Clostridium hylemonae sp. nov., isolated from human faeces publication-title: Int. J. Syst. Evol. Microbiol. doi: 10.1099/00207713-50-3-971 – volume: 9 start-page: 5588 year: 2018 ident: 10.1016/j.chom.2022.02.004_bib62 article-title: Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis publication-title: Food Funct. doi: 10.1039/C8FO01143E – volume: 25 start-page: 968 year: 2019 ident: 10.1016/j.chom.2022.02.004_bib108 article-title: Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer publication-title: Nat. Med. doi: 10.1038/s41591-019-0458-7 – volume: 12 start-page: 1 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib100 article-title: Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation publication-title: Gut Microbes doi: 10.1080/19490976.2020.1819155 – volume: 1004 start-page: 230 year: 1989 ident: 10.1016/j.chom.2022.02.004_bib23 article-title: Characterization of NAD-dependent 3α-and 3β-hydroxysteroid dehydrogenase and of NADP-dependent 7β-hydroxysteroid dehydrogenase from Peptostreptococcus productus. publication-title: Biochim. Biophys. Acta, Lipids Lipid Metab. doi: 10.1016/0005-2760(89)90272-5 – volume: 67 start-page: 2772 year: 2004 ident: 10.1016/j.chom.2022.02.004_bib104 article-title: Cloning of the bile salt hydrolase (bsh) gene from Enterococcus faecium FAIR-E 345 and chromosomal location of bsh genes in food enterococci publication-title: J. Food Prot. doi: 10.4315/0362-028X-67.12.2772 – volume: 117 start-page: 1244 year: 2017 ident: 10.1016/j.chom.2022.02.004_bib7 article-title: Heat-stabilised rice bran consumption by colorectal cancer survivors modulates stool metabolite profiles and metabolic networks: a randomised controlled trial publication-title: Br. J. Nutr. doi: 10.1017/S0007114517001106 – volume: 579 start-page: 123 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib76 article-title: Global chemical effects of the microbiome include new bile-acid conjugations publication-title: Nature doi: 10.1038/s41586-020-2047-9 – volume: 8 start-page: 617 year: 2019 ident: 10.1016/j.chom.2022.02.004_bib75 article-title: Effects of ursodeoxycholic acid on the gut microbiome and colorectal adenoma development publication-title: Cancer Med. doi: 10.1002/cam4.1965 – volume: 7 start-page: 9 year: 2019 ident: 10.1016/j.chom.2022.02.004_bib90 article-title: Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome publication-title: Microbiome doi: 10.1186/s40168-019-0628-3 – volume: 528 start-page: 148 year: 1978 ident: 10.1016/j.chom.2022.02.004_bib38 article-title: Partial purification and characterization of NADP-dependent 12α-hydroxysteroid dehydrogenase from Clostridium leptum publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2760(78)90060-7 – volume: 4 start-page: e6386 year: 2009 ident: 10.1016/j.chom.2022.02.004_bib45 article-title: Metabolomics reveals metabolic biomarkers of Crohn’s disease publication-title: PLoS ONE doi: 10.1371/journal.pone.0006386 – volume: 63 start-page: 1185 year: 1997 ident: 10.1016/j.chom.2022.02.004_bib21 article-title: Assessment of fecal bacteria with bile acid 7 α-dehydroxylating activity for the presence of bai-like genes publication-title: Appl. Environ. Microbiol. doi: 10.1128/aem.63.3.1185-1188.1997 – volume: 11 start-page: 1300 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib47 article-title: Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health publication-title: Gut Microbes doi: 10.1080/19490976.2020.1748261 – volume: 11 start-page: 685 year: 2015 ident: 10.1016/j.chom.2022.02.004_bib17 article-title: A biosynthetic pathway for a prominent class of microbiota-derived bile acids publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.1864 – volume: 40 start-page: 843 year: 2014 ident: 10.1016/j.chom.2022.02.004_bib40 article-title: Inflammatory bowel disease as a model for translating the microbiome publication-title: Immunity doi: 10.1016/j.immuni.2014.05.013 – volume: 22 start-page: 679 year: 2016 ident: 10.1016/j.chom.2022.02.004_bib80 article-title: Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers publication-title: Nat. Med. doi: 10.1038/nm.4086 – volume: 169 start-page: 985 year: 2017 ident: 10.1016/j.chom.2022.02.004_bib71 article-title: Wnt/β-catenin signaling, disease, and emerging therapeutic modalities publication-title: Cell doi: 10.1016/j.cell.2017.05.016 – volume: 582 start-page: 566 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib29 article-title: A metabolic pathway for bile acid dehydroxylation by the gut microbiome publication-title: Nature doi: 10.1038/s41586-020-2396-4 – volume: 70 start-page: 145 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib87 article-title: Colorectal cancer statistics, 2020 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21601 – volume: 39 start-page: 587 year: 1996 ident: 10.1016/j.chom.2022.02.004_bib12 article-title: Role of the gut in the pathophysiology of extrahepatic biliary obstruction publication-title: Gut doi: 10.1136/gut.39.4.587 – volume: 51 start-page: 39 year: 2001 ident: 10.1016/j.chom.2022.02.004_bib55 article-title: Clostridium hiranonis sp. nov., a human intestinal bacterium with bile acid 7α-dehydroxylating activity publication-title: Int. J. Syst. Evol. Microbiol. doi: 10.1099/00207713-51-1-39 – volume: 157 start-page: 720 year: 2006 ident: 10.1016/j.chom.2022.02.004_bib98 article-title: Effect of bile acid on the cell membrane functionality of lactic acid bacteria for oral administration publication-title: Res. Microbiol. doi: 10.1016/j.resmic.2006.04.002 – volume: 9 start-page: e85344 year: 2014 ident: 10.1016/j.chom.2022.02.004_bib89 article-title: Discovery of bile salt hydrolase inhibitors using an efficient high-throughput screening system publication-title: PLoS ONE doi: 10.1371/journal.pone.0085344 – volume: 66 start-page: 2502 year: 2000 ident: 10.1016/j.chom.2022.02.004_bib96 article-title: Bile salt hydrolase of Bifidobacterium longum-biochemical and genetic characterization publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.66.6.2502-2512.2000 – volume: 47 start-page: 1182 year: 2017 ident: 10.1016/j.chom.2022.02.004_bib9 article-title: The xenobiotic transporter Mdr1 enforces T cell homeostasis in the presence of intestinal bile acids publication-title: Immunity doi: 10.1016/j.immuni.2017.11.012 – volume: 13 start-page: 1 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib20 article-title: Completion of the gut microbial epi-bile acid pathway publication-title: Gut Microbes doi: 10.1080/19490976.2021.1907271 – volume: 569 start-page: 655 year: 2019 ident: 10.1016/j.chom.2022.02.004_bib63 article-title: Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases publication-title: Nature doi: 10.1038/s41586-019-1237-9 – volume: 39 start-page: 51 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib22 article-title: Cytokine regulation and function in T cells publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-061020-053702 – volume: 103 start-page: 3920 year: 2006 ident: 10.1016/j.chom.2022.02.004_bib42 article-title: Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0509592103 – volume: 13 start-page: 691 year: 2016 ident: 10.1016/j.chom.2022.02.004_bib72 article-title: Diet, microorganisms and their metabolites, and colon cancer publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2016.165 – volume: 487 start-page: 104 year: 2012 ident: 10.1016/j.chom.2022.02.004_bib16 article-title: Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice publication-title: Nature doi: 10.1038/nature11225 – volume: 84 year: 2018 ident: 10.1016/j.chom.2022.02.004_bib19 article-title: Metabolism of oxo-bile acids and characterization of recombinant 12α-hydroxysteroid dehydrogenases from bile acid 7α-dehydroxylating human gut bacteria publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.00235-18 – volume: 7 start-page: 22 year: 2016 ident: 10.1016/j.chom.2022.02.004_bib78 article-title: Consequences of bile salt biotransformations by intestinal bacteria publication-title: Gut Microbes doi: 10.1080/19490976.2015.1127483 – volume: 48 start-page: 202 year: 2018 ident: 10.1016/j.chom.2022.02.004_bib57 article-title: Human T cell development, localization, and function throughout life publication-title: Immunity doi: 10.1016/j.immuni.2018.01.007 – volume: 16 start-page: 1401 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib2 article-title: A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases publication-title: ACS Chem. Biol. doi: 10.1021/acschembio.1c00192 – volume: 120 start-page: 3049 year: 2014 ident: 10.1016/j.chom.2022.02.004_bib15 article-title: A prospective study of serum metabolites and colorectal cancer risk publication-title: Cancer doi: 10.1002/cncr.28799 – volume: 266 start-page: 10227 year: 1991 ident: 10.1016/j.chom.2022.02.004_bib49 article-title: Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)99213-6 – volume: 56 start-page: 1283 year: 2012 ident: 10.1016/j.chom.2022.02.004_bib26 article-title: Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease publication-title: J. Hepatol. doi: 10.1016/j.jhep.2012.01.019 – volume: 3 start-page: 1191 year: 2013 ident: 10.1016/j.chom.2022.02.004_bib11 article-title: Bile acid metabolism and signaling publication-title: Compr. Physiol. doi: 10.1002/cphy.c120023 – volume: 22 start-page: 1079 year: 2016 ident: 10.1016/j.chom.2022.02.004_bib85 article-title: Signals from the gut microbiota to distant organs in physiology and disease publication-title: Nat. Med. doi: 10.1038/nm.4185 – volume: 2 start-page: 2811 year: 2012 ident: 10.1016/j.chom.2022.02.004_bib34 article-title: Nuclear receptor control of enterohepatic circulation publication-title: Compr. Physiol. doi: 10.1002/cphy.c120007 – volume: 3 start-page: 14 year: 2013 ident: 10.1016/j.chom.2022.02.004_bib33 article-title: Metabolism of cholesterol and bile acids by the gut microbiota publication-title: Pathogens doi: 10.3390/pathogens3010014 – volume: 60 start-page: 463 year: 2011 ident: 10.1016/j.chom.2022.02.004_bib30 article-title: Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease publication-title: Gut doi: 10.1136/gut.2010.212159 – volume: 112 start-page: 516 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib56 article-title: Prediagnostic plasma bile acid levels and colon cancer risk: A prospective study publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/djz166 – volume: 29 start-page: 1366 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib61 article-title: A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2021.07.013 – volume: 4 start-page: 2384 year: 2013 ident: 10.1016/j.chom.2022.02.004_bib60 article-title: Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity publication-title: Nat. Commun. doi: 10.1038/ncomms3384 – volume: 5 start-page: 867 year: 2019 ident: 10.1016/j.chom.2022.02.004_bib73 article-title: Chemoproteomic profiling of gut microbiota-associated bile salt hydrolase activity publication-title: ACS Cent. Sci. doi: 10.1021/acscentsci.9b00147 – volume: 58 start-page: 1143 year: 2017 ident: 10.1016/j.chom.2022.02.004_bib101 article-title: Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents publication-title: J. Lipid Res. doi: 10.1194/jlr.M075143 – volume: 105 start-page: 13580 year: 2008 ident: 10.1016/j.chom.2022.02.004_bib50 article-title: Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0804437105 – volume: 599 start-page: 294 year: 1980 ident: 10.1016/j.chom.2022.02.004_bib14 article-title: Membrane lipid composition and susceptibility to bile salt damage publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(80)90075-9 – volume: 361 start-page: 512 year: 2003 ident: 10.1016/j.chom.2022.02.004_bib35 article-title: Gut flora in health and disease publication-title: Lancet doi: 10.1016/S0140-6736(03)12489-0 – volume: 29 start-page: 1294 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib59 article-title: Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease publication-title: Cell Host Microbe doi: 10.1016/j.chom.2021.06.019 – volume: 141 start-page: 1773 year: 2011 ident: 10.1016/j.chom.2022.02.004_bib43 article-title: Bile acid is a host factor that regulates the composition of the cecal microbiota in rats publication-title: Gastroenterology doi: 10.1053/j.gastro.2011.07.046 – volume: 105 start-page: 1907 year: 2013 ident: 10.1016/j.chom.2022.02.004_bib3 article-title: Human gut microbiome and risk for colorectal cancer publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/djt300 – volume: 31 start-page: 1305 year: 2000 ident: 10.1016/j.chom.2022.02.004_bib5 article-title: Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid publication-title: Hepatology doi: 10.1053/jhep.2000.7877 – volume: 19 start-page: 24 year: 1978 ident: 10.1016/j.chom.2022.02.004_bib52 article-title: Measurement and subcellular distribution of choloyl-CoA synthetase and bile acid-CoA:amino acid N-acyltransferase activities in rat liver publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)41573-1 – volume: 8 start-page: 341 year: 2014 ident: 10.1016/j.chom.2022.02.004_bib69 article-title: A tale of two diseases: the history of inflammatory bowel disease publication-title: J. Crohn’s Colitis doi: 10.1016/j.crohns.2013.09.009 – volume: 7 start-page: 207 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib110 article-title: Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis publication-title: Cell Death Discov. doi: 10.1038/s41420-021-00589-8 – volume: 7 start-page: e37182 year: 2018 ident: 10.1016/j.chom.2022.02.004_bib109 article-title: A selective gut bacterial bile salt hydrolase alters host metabolism publication-title: eLife doi: 10.7554/eLife.37182 – volume: 9 start-page: 523 year: 2018 ident: 10.1016/j.chom.2022.02.004_bib39 article-title: Bile acid oxidation by Eggerthella lenta strains C592 and DSM 2243T publication-title: Gut Microbes – volume: 593 start-page: 147 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib10 article-title: CAR directs T cell adaptation to bile acids in the small intestine publication-title: Nature doi: 10.1038/s41586-021-03421-6 – volume: 16 start-page: 341 year: 2016 ident: 10.1016/j.chom.2022.02.004_bib79 article-title: Gut microbiota, metabolites and host immunity publication-title: Nat. Rev. Immunol. doi: 10.1038/nri.2016.42 – volume: 29 start-page: 625 year: 2005 ident: 10.1016/j.chom.2022.02.004_bib6 article-title: The interaction between bacteria and bile publication-title: FEMS Microbiol. Rev. doi: 10.1016/j.femsre.2004.09.003 – volume: 15 start-page: 111 year: 2018 ident: 10.1016/j.chom.2022.02.004_bib46 article-title: Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2017.119 – volume: 21 start-page: 653 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib84 article-title: The inflammatory pathogenesis of colorectal cancer publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-021-00534-x – volume: 142 start-page: 46 year: 2012 ident: 10.1016/j.chom.2022.02.004_bib68 article-title: Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review publication-title: Gastroenterology doi: 10.1053/j.gastro.2011.10.001 – volume: 576 start-page: 143 year: 2019 ident: 10.1016/j.chom.2022.02.004_bib37 article-title: Bile acid metabolites control TH17 and Treg cell differentiation publication-title: Nature doi: 10.1038/s41586-019-1785-z – volume: 452 start-page: 165 year: 1976 ident: 10.1016/j.chom.2022.02.004_bib93 article-title: Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2744(76)90068-1 – volume: 18 start-page: 2609 year: 2012 ident: 10.1016/j.chom.2022.02.004_bib41 article-title: Leaky gut and the liver: a role for bacterial translocation in nonalcoholic steatohepatitis publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v18.i21.2609 – volume: 47 start-page: 241 year: 2006 ident: 10.1016/j.chom.2022.02.004_bib77 article-title: Bile salt biotransformations by human intestinal bacteria publication-title: J. Lipid Res. doi: 10.1194/jlr.R500013-JLR200 – volume: 17 start-page: 225 year: 2013 ident: 10.1016/j.chom.2022.02.004_bib82 article-title: Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-β-muricholic acid, a naturally occurring FXR antagonist publication-title: Cell Metab. doi: 10.1016/j.cmet.2013.01.003 – volume: 147 start-page: 3403 year: 2001 ident: 10.1016/j.chom.2022.02.004_bib24 article-title: Genes encoding bile salt hydrolases and conjugated bile salt transporters in Lactobacillus johnsonii 100-100 and other Lactobacillus species publication-title: Microbiology (Reading) doi: 10.1099/00221287-147-12-3403 – volume: 58 start-page: 1155 year: 2019 ident: 10.1016/j.chom.2022.02.004_bib99 article-title: Interplay between bile acids and the gut microbiota promotes intestinal carcinogenesis publication-title: Mol. Carcinog. doi: 10.1002/mc.22999 – volume: 48 start-page: 206 year: 2001 ident: 10.1016/j.chom.2022.02.004_bib103 article-title: The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis publication-title: Gut doi: 10.1136/gut.48.2.206 – volume: 61 start-page: 2514 year: 1995 ident: 10.1016/j.chom.2022.02.004_bib13 article-title: Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens publication-title: Appl. Environ. Microbiol. doi: 10.1128/aem.61.7.2514-2520.1995 – volume: 4 start-page: 293 year: 2019 ident: 10.1016/j.chom.2022.02.004_bib27 article-title: Gut microbiome structure and metabolic activity in inflammatory bowel disease publication-title: Nat. Microbiol. doi: 10.1038/s41564-018-0306-4 – volume: 159 start-page: 956 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib92 article-title: Bile acids signal via TGR5 to activate intestinal stem cells and epithelial regeneration publication-title: Gastroenterology doi: 10.1053/j.gastro.2020.05.067 – volume: 27 start-page: 109 year: 2017 ident: 10.1016/j.chom.2022.02.004_bib95 article-title: Regulatory T cells in cancer immunotherapy publication-title: Cell Res. doi: 10.1038/cr.2016.151 – volume: 54 start-page: 102719 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib32 article-title: Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor publication-title: EBioMedicine doi: 10.1016/j.ebiom.2020.102719 – volume: 8 start-page: e70803 year: 2013 ident: 10.1016/j.chom.2022.02.004_bib102 article-title: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults publication-title: PLoS ONE doi: 10.1371/journal.pone.0070803 – volume: 15 start-page: 1197 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib107 article-title: Modulation of the gut microbiota-farnesoid X receptor axis improves deoxycholic acid-induced intestinal inflammation in mice publication-title: J. Crohn’s Colitis doi: 10.1093/ecco-jcc/jjab003 – volume: 450 start-page: 142 year: 1976 ident: 10.1016/j.chom.2022.02.004_bib65 article-title: 3α-, 7α- and 12α-hydroxysteroid dehydrogenase activities from Clostridium perfringens. publication-title: Biochim. Biophys. Acta, Lipids Lipid Metab. doi: 10.1016/0005-2760(76)90086-2 – volume: 45 start-page: 802 year: 2016 ident: 10.1016/j.chom.2022.02.004_bib36 article-title: Bile acids control Inflammation and metabolic disorder through inhibition of NLRP3 inflammasome publication-title: Immunity doi: 10.1016/j.immuni.2016.09.008 – volume: 16 start-page: 295 year: 2016 ident: 10.1016/j.chom.2022.02.004_bib97 article-title: Development and maintenance of intestinal regulatory T cells publication-title: Nat. Rev. Immunol. doi: 10.1038/nri.2016.36 – volume: 18 start-page: 335 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib94 article-title: The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-020-00404-2 – volume: 56 start-page: 66 year: 2017 ident: 10.1016/j.chom.2022.02.004_bib31 article-title: Bile acids and colon cancer: Is FXR the solution of the conundrum? publication-title: Mol. Aspects Med. doi: 10.1016/j.mam.2017.04.002 – volume: 37 start-page: 992 year: 1979 ident: 10.1016/j.chom.2022.02.004_bib66 article-title: Bile salt 3 α- and 12 α-hydroxysteroid dehydrogenases from Eubacterium lentum and related organisms publication-title: Appl. Environ. Microbiol. doi: 10.1128/aem.37.5.992-1000.1979 – volume: 66 start-page: 568 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib106 article-title: Deoxycholic acid-induced gut dysbiosis disrupts bile acid Enterohepatic circulation and promotes intestinal Inflammation publication-title: Dig. Dis. Sci. doi: 10.1007/s10620-020-06208-3 – volume: 11 start-page: 723 year: 2011 ident: 10.1016/j.chom.2022.02.004_bib70 article-title: Protective and pathogenic functions of macrophage subsets publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3073 – volume: 16 start-page: 318 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib1 article-title: Development of a covalent inhibitor of gut bacterial bile salt hydrolases publication-title: Nat. Chem. Biol. doi: 10.1038/s41589-020-0467-3 – volume: 599 start-page: 458 year: 2021 ident: 10.1016/j.chom.2022.02.004_bib81 article-title: Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians publication-title: Nature doi: 10.1038/s41586-021-03832-5 – volume: 581 start-page: 475 year: 2020 ident: 10.1016/j.chom.2022.02.004_bib8 article-title: Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells publication-title: Nature doi: 10.1038/s41586-020-2193-0 – volume: 12 start-page: 720 year: 2015 ident: 10.1016/j.chom.2022.02.004_bib51 article-title: The global burden of IBD: from 2015 to 2025 publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2015.150 |
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| SubjectTerms | Bile Acids and Salts Carcinogenesis Gastrointestinal Microbiome Humans Inflammation Prospective Studies |
| Title | Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis |
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