Nucleotide and Peptide Sequences of the Open Reading Frame Encoding a Truncated Toxin A Gene of Clostridium difficile Strain CCUG 20309

Database Accession No.: AF053400 The open reading frame encoding a putative truncated toxin A gene of Clostridium difficile in strain CCUG 20309 (ATCC 8864), a strain that produces toxin B but not toxin A, was sequenced by cycle sequencing method. The coding region contains 2097 base pairs and has a...

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Bibliographic Details
Published inDNA sequence Vol. 10; no. 2; pp. 93 - 96
Main Authors Song, Keang Peng, Bai, Xin Lai, Chang, Siao Yun
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 1999
Taylor & Francis
Subjects
Amino Acid Sequence
Bacterial Toxins
Base Sequence
C. difficile
Clostridium difficile - genetics
DNA, Bacterial
enterotoxic
Enterotoxins - genetics
Molecular Sequence Data
Open Reading Frames
pathogenicity
Peptides - genetics
Toxin A
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Summary:Database Accession No.: AF053400 The open reading frame encoding a putative truncated toxin A gene of Clostridium difficile in strain CCUG 20309 (ATCC 8864), a strain that produces toxin B but not toxin A, was sequenced by cycle sequencing method. The coding region contains 2097 base pairs and has a GC content of 26.4 %. The deduced polypeptide is 50 kDa and is generally hydrophilic. Although strain CCUG 20309 of C. difficile was reported not to produce toxin A, it is entero-toxic, an inherent property of toxin A in pathogenic strains of C. difficile. It therefore remains to be determined whether a truncated form of toxin A could actually be expressed from the open reading frame by this strain of C. difficile.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:1042-5179
1029-2365
DOI:10.3109/10425179909008423