Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer

• Published in: Hypoxia Vol. 5; pp. 1 - 9
• Main Authors: Seeley, Todd W, Sternlicht, Mark D, Klaus, Stephen J, Neff, Thomas B, Liu, David Y
• Format: Journal Article
• Language: English
• Published: New Zealand Taylor & Francis Ltd 01.01.2017; Dove Medical Press
• Subjects: Age; Amino acids; Anemia; Angiogenesis; Breast cancer; Clinical trials; Endoplasmic reticulum; Females; Gene expression; Hypoxia; Kidney diseases; Kinases; Laboratory animals; Metastasis; Mutation; Original Research; Proteins; Studies; Tumors; Vascular endothelial growth factor; Canada; United States > US; hypoxia-inducible factor; erythropoiesis; cancer progression; hypoxia-inducible factor prolyl hydroxylase inhibitors; MMTV-Neu breast cancer model; vascular endothelial growth factor

The effects of pharmacological hypoxia-inducible factor (HIF) stabilization were investigated in the MMTV-Neu -YD5 (NeuYD) mouse model of breast cancer. This study first confirmed the sensitivity of this model to increased vascular endothelial growth factor (VEGF), using bigenic NeuYD;MMTV-VEGF-25 m...