PITX2 and NEURL1 SNP polymorphisms in Hungarian atrial fibrillation patients determined by quantitative real-time PCR and melting curve analysis

• Published in: Journal of biotechnology Vol. 299; pp. 44 - 49
• Main Authors: Szirák, Krisztina, Soltész, Beáta, Hajas, Orsolya, Urbancsek, Réka, Nagy-Baló, Edina, Penyige, András, Csanádi, Zoltán, Nagy, Bálint
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 20.06.2019
• Subjects: Adaptor Proteins, Signal Transducing; Adult; Aged; Atrial fibrillation; Atrial Fibrillation - genetics; Atrial Fibrillation - metabolism; beta Catenin - metabolism; Calcium-Binding Proteins; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Homeobox Protein PITX2; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; Hungary; Intercellular Signaling Peptides and Proteins - metabolism; Jagged-1 Protein - metabolism; Male; Middle Aged; NEURL1; PITX2; Polymorphism, Single Nucleotide; Protein Interaction Maps; Real-Time Polymerase Chain Reaction; rs2595104; rs6584555; Single nucleotide polymorphism; Transcription Factors - genetics; Transcription Factors - metabolism; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; White People - genetics; Hungary; rs2595104; AF; Atrial fibrillation; rs6584555; NEURL1; Single nucleotide polymorphism; PITX2

•The allele and genotype frequencies of the SNP in the enhancer region of PITX2 (rs 2595104) and the SNP in the NEURL1 gene (rs 6584555) were determined in a healthy population and in patients having atrial fibrillation.•The linkage disequilibrium was calculated between the two loci.•We found indire...