Vitamin E sequestration by liver fat in humans

• Published in: JCI insight Vol. 5; no. 1
• Main Authors: Violet, Pierre-Christian, Ebenuwa, Ifechukwude C., Wang, Yu, Niyyati, Mahtab, Padayatty, Sebastian J., Head, Brian, Wilkins, Kenneth, Chung, Stacey, Thakur, Varsha, Ulatowski, Lynn, Atkinson, Jeffrey, Ghelfi, Mikel, Smith, Sheila, Tu, Hongbin, Bobe, Gerd, Liu, Chia-Ying, Herion, David W., Shamburek, Robert D., Manor, Danny, Traber, Maret G., Levine, Mark
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 16.01.2020
• Subjects: Adolescent; Adult; alpha-Tocopherol - administration & dosage; alpha-Tocopherol - pharmacokinetics; Cell Line; Clinical Medicine; Fatty Liver - drug therapy; Female; Hep G2 Cells; Humans; Kinetics; Lipids; Lipoproteins; Liver - metabolism; Obesity; Vitamin E - administration & dosage; Vitamin E - pharmacokinetics; Young Adult; Metabolism; Obesity; Hepatology

BACKGROUNDWe hypothesized that obesity-associated hepatosteatosis is a pathophysiological chemical depot for fat-soluble vitamins and altered normal physiology. Using α-tocopherol (vitamin E) as a model vitamin, pharmacokinetics and kinetics principles were used to determine whether excess liver fat...