T-Cell Immunophenotyping Distinguishes Active From Latent Tuberculosis

• Published in: The Journal of infectious diseases Vol. 208; no. 6; pp. 952 - 968
• Main Authors: Pollock, Katrina M., Whitworth, Hilary S., Montamat-Sicotte, Damien J., Grass, Lisa, Cooke, Graham S., Kapembwa, Moses S., Kon, Onn M., Sampson, Robert D., Taylor, Graham P., Lalvani, Ajit
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.09.2013
• Subjects: Adult; BACTERIA; Biological and medical sciences; Biological markers; Biomarkers - blood; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Coinfection; Female; Fundamental and applied biological sciences. Psychology; HIV; HIV Infections - immunology; HIV Infections - microbiology; Human immunodeficiency virus; Humans; Immunophenotyping; Infections; Infectious diseases; Interferon-gamma - blood; Interleukin-2 - blood; Latent tuberculosis; Latent Tuberculosis - diagnosis; Latent Tuberculosis - immunology; Major and Brief Reports; Male; Medical sciences; Microbiology; Middle Aged; Mycobacterium tuberculosis; Phenotype; Phenotypes; Prospective Studies; Pulmonary tuberculosis; Receptors, Interleukin-7 - genetics; Receptors, Interleukin-7 - metabolism; T lymphocytes; T-Lymphocyte Subsets - immunology; Tuberculosis; Tumor Necrosis Factor-alpha - blood; Infection; Latent tuberculosis; T-Lymphocyte

Background. Changes in the phenotype and function of Mycobacterium tuberculosis (M. tuberculosis)-specific CD4⁺ and CD8⁺ T-cell subsets in response to stage of infection may allow discrimination between active tuberculosis and latent tuberculosis infection. Methods. A prospective comparison of M. tu...