Microdialysis Evaluation of Atomoxetine Brain Penetration and Central Nervous System Pharmacokinetics in Rats

• Published in: Drug metabolism and disposition Vol. 37; no. 1; pp. 137 - 142
• Main Authors: Kielbasa, William, Kalvass, J. Cory, Stratford, Robert
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.01.2009; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Adrenergic Uptake Inhibitors - blood; Adrenergic Uptake Inhibitors - cerebrospinal fluid; Adrenergic Uptake Inhibitors - pharmacokinetics; Animals; Atomoxetine Hydrochloride; Biological and medical sciences; Blood-Brain Barrier; Brain - metabolism; Male; Medical sciences; Microdialysis; Pharmacology. Drug treatments; Propylamines - blood; Propylamines - cerebrospinal fluid; Propylamines - pharmacokinetics; Rats; Rats, Wistar; Spinal Cord - metabolism; Evaluation; Rat; Psychotropic; Rodentia; Central nervous system; Catecholamine; Reuptake inhibitor; Encephalon; Vertebrata; Mammalia; Microdialysis; Penetration; Atomoxetine; Animal; Neurotransmitter; Norepinephrine; Pharmacokinetics

A comprehensive in vivo evaluation of brain penetrability and central nervous system (CNS) pharmacokinetics of atomoxetine in rats was conducted using brain microdialysis. We sought to determine the nature and extent of transport at the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier...