Directed differentiation of pluripotent stem cells: from developmental biology to therapeutic applications

• Published in: Cold Spring Harbor Symposia on Quantitative Biology Vol. 73; p. 101
• Main Authors: Irion, S, Nostro, M C, Kattman, S J, Keller, G M
• Format: Journal Article
• Language: English
• Published: United States 2008
• Subjects: Animals; Cell Differentiation; Cell Line; Developmental Biology; Drug Discovery; Embryonic Development; Endoderm - cytology; Endoderm - embryology; Endoderm - metabolism; Female; Fetal Heart - cytology; Fetal Heart - embryology; Fetal Heart - metabolism; Gastrulation; Genes, Reporter; Hematopoiesis; Humans; Mesoderm - cytology; Mesoderm - embryology; Mesoderm - metabolism; Mice; Mice, Transgenic; Models, Biological; Pluripotent Stem Cells - cytology; Pluripotent Stem Cells - metabolism; Pregnancy; Stem Cell Transplantation

The discovery of human pluripotent stem cells has laid the foundation for an emerging new field of biomedical research that holds promise to develop models of human development and disease, establish new strategies for discovering and testing drugs, and provide systems for the generation of cells an...