Staphylococcus aureus coagulases are exploitable yet stable public goods in clinically relevant conditions

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 50; pp. E11771 - E11779
• Main Authors: Trivedi, Urvish, Madsen, Jonas S., Everett, Jake, Fell, Cody, Russel, Jakob, Haaber, Jakob, Crosby, Heidi A., Horswill, Alexander R., Burmølle, Mette, Rumbaugh, Kendra P., Sørensen, Søren J.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.12.2018
• Series: PNAS Plus
• Subjects: Antimicrobial agents; Biofilms; Biofilms - growth & development; Biological Sciences; Blood Coagulation; Coagulase - genetics; Coagulase - physiology; Coagulation; Drug resistance; Humans; Local population; Methicillin; Methicillin-Resistant Staphylococcus aureus - enzymology; Methicillin-Resistant Staphylococcus aureus - pathogenicity; Microbiota - genetics; Microbiota - physiology; Models, Biological; Mutation; Overexploitation; Photomicrographs; PNAS Plus; Public good; Staphylococcal Infections - blood; Staphylococcal Infections - microbiology; Staphylococcus aureus; Staphylococcus infections; Virulence; Viscosity; coagulases; biofilms; public goods; Staphylococcus aureus; social evolution

Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, som...