Clinical Evaluation of 6-Chloropurine in Leukemia of Adults
Abstract 1. 6-Chloropurine, an analogue of 6-mercaptopurine, has been shown to produce complete remissions in three and partial remissions in eight of 30 adults with acute leukemia. No beneficial effects were obtained in four additional patients known to be resistant to 6-mercaptopurine. 2. Three of...
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| Published in | Blood Vol. 13; no. 8; pp. 705 - 724 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.08.1958
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Abstract
1. 6-Chloropurine, an analogue of 6-mercaptopurine, has been shown to produce complete remissions in three and partial remissions in eight of 30 adults with acute leukemia. No beneficial effects were obtained in four additional patients known to be resistant to 6-mercaptopurine.
2. Three of four patients with chronic granulocytic leukemia responded to 6-chloropurine.
3. Slight objective improvement was noted in patients with lymphomas but only at the point of hematologic toxicity.
4. A high incidence of jaundice was noted, but it is difficult to relate this definitely to the therapy.
5. While 6-chloropurine appears to be slightly superior to 6-mercaptopurine in acute leukemia in adults, the pattern of response would indicate that these agents have a similar mechanism and range of therapeutic activity. |
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| AbstractList | Abstract
1. 6-Chloropurine, an analogue of 6-mercaptopurine, has been shown to produce complete remissions in three and partial remissions in eight of 30 adults with acute leukemia. No beneficial effects were obtained in four additional patients known to be resistant to 6-mercaptopurine.
2. Three of four patients with chronic granulocytic leukemia responded to 6-chloropurine.
3. Slight objective improvement was noted in patients with lymphomas but only at the point of hematologic toxicity.
4. A high incidence of jaundice was noted, but it is difficult to relate this definitely to the therapy.
5. While 6-chloropurine appears to be slightly superior to 6-mercaptopurine in acute leukemia in adults, the pattern of response would indicate that these agents have a similar mechanism and range of therapeutic activity. |
| Author | and, David A. Karnofsky Burchenal, Joseph H. Ellison, Rose Ruth |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/13560569$$D View this record in MEDLINE/PubMed |
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| Copyright | 1958 American Society of Hematology |
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| Keywords | MERCAPTOPURINE/related compounds LEUKEMIA/therapy |
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| References | Bendich, Russell, Fox (bib2) 1954; 76 Braunsteiner, Friend (bib9) 1954; 100 (bib8) 1956; 11 Murphy, Tan, Ellison, Burchenal (bib3) 1955; 2 Hutchison, D. J.: Unpublished data. Burchenal, J. H.: Unpublished data. Burchenal, Murphy, Ellison, Sykes, Tan, Leone, Karnofsky, Craver, Dargeon, Rhoads (bib1) 1953; 8 Clarke, Philips, Sternberg, Stock (bib4) 1954; 60 Burchenal, Krakoff (bib10) 1956; 96 Philips, Sternberg, Hamilton, Clarke (bib7) 1954; 60 |
| References_xml | – volume: 96 start-page: 567 year: 1956 ident: bib10 article-title: Newer agents in the treatment of leukemia publication-title: A. M. A. Arch. Int. Med. contributor: fullname: Krakoff – volume: 8 start-page: 965 year: 1953 ident: bib1 article-title: Clinical evaluation of a new antimetabolite, 6-mercaptopurine in the treatment of leukemia and allied diseases publication-title: Blood contributor: fullname: Rhoads – volume: 2 start-page: 36 year: 1955 ident: bib3 article-title: Clinical evaluation of 6-chloropurine and thioguanine. publication-title: Proc. Am. A. Cancer Research contributor: fullname: Burchenal – volume: 60 start-page: 283 year: 1954 ident: bib7 article-title: The toxic effects of 6-mercaptopurine and related compounds publication-title: Ann. New York Acad. Sc. contributor: fullname: Clarke – volume: 60 start-page: 235 year: 1954 ident: bib4 article-title: Effects of 6-mercaptopurine and analogs on experimental tumors publication-title: Ann. New York Acad. Sc. contributor: fullname: Stock – volume: 76 start-page: 6073 year: 1954 ident: bib2 article-title: The synthesis and properties of 6-chloropurine and purine publication-title: J. Am. Chem. Soc. contributor: fullname: Fox – volume: 100 start-page: 665 year: 1954 ident: bib9 article-title: Viral hepatitis associated with transplantable mouse leukemia. I. Acute hepatic manifestations following treatment with urethane or methylformamide publication-title: J. Exper. Med. contributor: fullname: Friend – volume: 11 start-page: 676 year: 1956 ident: bib8 article-title: Clinical Studies Panel of the Cancer Chemotherapy National Service Center. Criteria for the evaluation of response to treatment in acute leukemia publication-title: Blood |
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1. 6-Chloropurine, an analogue of 6-mercaptopurine, has been shown to produce complete remissions in three and partial remissions in eight of 30... |
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| SubjectTerms | Leukemia - therapy Mercaptopurine - analogs & derivatives Purines |
| Title | Clinical Evaluation of 6-Chloropurine in Leukemia of Adults |
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