Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

• Published in: Science (American Association for the Advancement of Science) Vol. 363; no. 6430; pp. 993 - 998
• Main Authors: Grootjans, Joep, Krupka, Niklas, Hosomi, Shuhei, Matute, Juan D., Hanley, Thomas, Saveljeva, Svetlana, Gensollen, Thomas, Heijmans, Jarom, Li, Hai, Limenitakis, Julien P., Ganal-Vonarburg, Stephanie C., Suo, Shengbao, Luoma, Adrienne M., Shimodaira, Yosuke, Duan, Jinzhi, Shih, David Q., Conner, Margaret E., Glickman, Jonathan N., Fuhler, Gwenny M., Palm, Noah W., de Zoete, Marcel R., van der Woude, C. Janneke, Yuan, Guo-Cheng, Wucherpfennig, Kai W., Targan, Stephan R., Rosenstiel, Philip, Flavell, Richard A., McCoy, Kathy D., Macpherson, Andrew J., Kaser, Arthur, Blumberg, Richard S.
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 01.03.2019; The American Association for the Advancement of Science
• Subjects: Animals; Autophagy; Autophagy-Related Proteins - genetics; Commensalism; Endoplasmic reticulum; Endoplasmic Reticulum Stress; Epithelial cells; Epithelial Cells - immunology; Epithelium; Gastrointestinal tract; Humans; Immunity, Mucosal; Immunoglobulin A; Immunoglobulin A - immunology; Immunoglobulins; Inflammation; Intestinal Mucosa - immunology; Lamina propria; Lymphocytes; Lymphocytes T; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiota; Microorganisms; Mucosa; Peritoneum; Phagocytosis; Plasma cells; Plasma Cells - immunology; Stress; Tissue Culture Techniques; X-Box Binding Protein 1 - genetics

Immunoglobulin A (IgA) is the major secretory immunoglobulin isotype found at mucosal surfaces, where it regulates microbial commensalism and excludes luminal factors from contacting intestinal epithelial cells (IECs). IgA is induced by both T cell–dependent and –independent (TI) pathways. However,...