Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load

• Published in: International journal of pharmaceutics Vol. 559; pp. 130 - 137
• Main Authors: Jonsson, Henrik, Öhman-Mägi, Caroline, Alderborn, Göran, Isaksson, Per, Frenning, Göran
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.03.2019
• Subjects: Cracking; Fragmentation; Galenisk farmaci; Granule; Pharmaceutics; Triaxial; Uniaxial; Uniaxial; Cracking; Granule; Triaxial; Fragmentation

[Display omitted] Cracking patterns in four kinds of granules, based on the common pharmaceutical excipient microcrystalline cellulose (MCC) and subject to compressive load, were examined. The initial pore structure and the location of initial failure under uniaxial compression were assessed using X...