Murinization and H Chain Isotype Matching of the Anti-GITR Antibody DTA-1 Reduces Immunogenicity-Mediated Anaphylaxis in C57BL/6 Mice

• Published in: The Journal of immunology (1950) Vol. 198; no. 11; pp. 4502 - 4512
• Main Authors: Belmar, Nicole A, Chan, Sarah W, Fox, Melvin I, Samayoa, Josue A, Stickler, Marcia M, Tran, Ninian N, Akamatsu, Yoshiko, Hollenbaugh, Diane, Harding, Fiona A, Alvarez, Hamsell M
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 01.06.2017
• Subjects: Anaphylaxis; Anaphylaxis - immunology; Animal models; Animals; Antitumor activity; Body temperature; Cancer immunotherapy; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell Line, Tumor; Drug development; Glucocorticoid-Induced TNFR-Related Protein - immunology; Glucocorticoids; Immune response; Immunogenicity; Immunoglobulin E; Immunoglobulin G; Immunoglobulin Isotypes - immunology; Immunoregulation; Interleukin 4; Interleukin-4 - immunology; Lymphocytes; Lymphocytes T; Mice; Mice, Inbred C57BL; Oncology; Proteins; Rats; Receptors, IgG - immunology; Strain; T-Lymphocytes, Regulatory - immunology; Tumor necrosis factor receptors

Recent advances in immuno-oncology have shown that the immune system can be activated to induce long-term, durable antitumor responses. For immuno-oncology drug development, immune activation is often explored using rat Abs in immunocompetent mouse models. Although these models can be used to show e...