Quantitative Evidence for Revising the Definition of Primary Graft Dysfunction after Lung Transplant

• Published in: American journal of respiratory and critical care medicine Vol. 197; no. 2; pp. 235 - 243
• Main Authors: Cantu, Edward, Diamond, Joshua M., Suzuki, Yoshikazu, Lasky, Jared, Schaufler, Christian, Lim, Brian, Shah, Rupal, Porteous, Mary, Lederer, David J., Kawut, Steven M., Palmer, Scott M., Snyder, Laurie D., Hartwig, Matthew G., Lama, Vibha N., Bhorade, Sangeeta, Bermudez, Christian, Crespo, Maria, McDyer, John, Wille, Keith, Orens, Jonathan, Shah, Pali D., Weinacker, Ann, Weill, David, Wilkes, David, Roe, David, Hage, Chadi, Ware, Lorraine B., Bellamy, Scarlett L., Christie, Jason D.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 15.01.2018
• Subjects: Adult; Biomarkers - analysis; Cause of Death; Cohort Studies; Consensus; Female; Graft Rejection; Graft Survival; Humans; Kaplan-Meier Estimate; Logistic Models; Lung Transplantation - adverse effects; Lung Transplantation - methods; Lung Transplantation - mortality; Male; Middle Aged; Original; Primary Graft Dysfunction - mortality; Primary Graft Dysfunction - pathology; Proportional Hazards Models; Reproducibility of Results; Retrospective Studies; Risk Assessment; Severity of Illness Index; Survival Rate; Time Factors; United States; Young Adult; United States; lung transplant; lung transplant outcomes; primary graft dysfunction

Primary graft dysfunction (PGD) is a form of acute lung injury that occurs after lung transplantation. The definition of PGD was standardized in 2005. Since that time, clinical practice has evolved, and this definition is increasingly used as a primary endpoint for clinical trials; therefore, valida...