Effects of ketoconazole and esomeprazole on the pharmacokinetics of pazopanib in patients with solid tumors - Tan, Antoinette R.; Gibbon, Darlene G.; Stein, Mark N.; Lindquist, Diana; Edenfield, Jeffery W.; Martin, Julie C.; Gregory, Charles; Suttle, A. Benjamin; Tada, Hiroomi; Botbyl, Jeffrey; Stephenson, Joseph J. (Cancer chemotherapy and pharmacology, 2013)
Keywords: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors - administration & dosage; Angiogenesis Inhibitors - adverse effects; Angiogenesis Inhibitors - pharmacokinetics; Angiogenesis Inhibitors - therapeutic use; Antineoplastic agents; Biological and medical sciences; Cancer Research; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Esomeprazole - administration & dosage; Esomeprazole - adverse effects; Esomeprazole - pharmacology; Female; Humans; Ketoconazole - administration & dosage; Ketoconazole - adverse effects; Ketoconazole - pharmacology; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasms - drug therapy; Neoplasms - metabolism; Oncology; Original Article; Pharmacology. Drug treatments; Pharmacology/Toxicology; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - adverse effects; Proton Pump Inhibitors - pharmacology; Pyrimidines - administration & dosage; Pyrimidines - adverse effects; Pyrimidines - pharmacokinetics; Pyrimidines - therapeutic use; Sulfonamides - administration & dosage; Sulfonamides - adverse effects; Sulfonamides - pharmacokinetics; Sulfonamides - therapeutic use; Tumors; Ketoconazole; Pharmacokinetics; CYP3A4; Esomeprazole; Pazopanib; Human; Imidazole derivatives; Solid tumor; Cytochrome CYP3A4; Enzyme; Tyrosine kinase inhibitor; Isozyme; Transferases; Cytochrome P450; H; Enzyme inhibitor; K; Malignant tumor; Proton pump inhibitor; Benzimidazole derivatives; exchanging ATPase; Hydrolases; Protein-tyrosine kinase; Cancer