Normal Values of Real-Time 3-Dimensional Echocardiographic Parameters in a Healthy Japanese Population The JAMP-3D Study

• Published in: Circulation Journal Vol. 76; no. 5; pp. 1177 - 1181
• Main Authors: Yamamoto, Kazuhiro, Iwakura, Katsuomi, Watanabe, Hiroyuki, Yoshikawa, Junichi, Abe, Yukio, Murata, Kazuya, Hirata, Kumiko, Yamada, Satoshi, Nishigami, Kazuhiro, Nakatani, Satoshi, Fukuda, Shota, Negishi, Kazuaki, Ota, Takahiro, Ito, Hiroshi, Izumi, Chisato, Hirashiki, Akihiro, Hayashida, Akihiro, Daimon, Masao, Hidaka, Takayuki, Yuasa, Toshinori, Tanaka, Nobuhiro, Sakata, Konomi, Iwai-Takano, Masumi, Nishikage, Tomoko
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 2012
• Subjects: Adult; Aged; Asian Continental Ancestry Group; Cardiovascular Diseases - diagnostic imaging; Cardiovascular Diseases - pathology; Cardiovascular Diseases - physiopathology; Echocardiography; Echocardiography, Three-Dimensional; Heart Ventricles - diagnostic imaging; Humans; Japan; Japanese; Male; Middle Aged; Organ Size - physiology; Population; Stroke Volume - physiology; Ventricular Function, Left - physiology
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-11-1256

Background: The recently developed real-time 3-dimensional echocardiography (RT3DE) is a promising imaging method to quantify cardiac chamber volumes and their functions in clinical practice. However, normal reference values of RT3DE parameters have not been fully investigated in a large, healthy Japanese population. Methods and Results: This study consisted of 410 healthy subjects aged from 20 to 69 years who had a RT3DE at one of the 23 collaborating institutions. All subjects had no history of cardiac disease and no risk factors. The mean values in men and women were as follows: 50±12ml/m2 and 46±9ml/m2 for left ventricular (LV) end-diastolic volume index, 19±5ml/m2 and 17±4ml/m2 for end-systolic volume index, 61±4% and 63±4% for ejection fraction, 64±12g/m2 and 56±11g/m2 for mass index, 23±6ml/m2 and 24±6ml/m2 for left atrial (LA) maximum volume index, 10±3ml/m2 and 10±3ml/m2 for minimum volume index, and 58±6% and 58±6% for percent volume change. LV sizes decreased with age, whereas LV mass index did not change. LA sizes slightly increased with age. Conclusions: This multicenter investigation determined normal reference values for LV and LA sizes, and their functional parameters on RT3DE in a large, healthy Japanese population. The results of the present study support the use of RT3DE for the diagnosis and management of cardiovascular disease. (Circ J 2012; 76: 1177-1181)