C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes

• Published in: The Journal of immunology (1950) Vol. 198; no. 11; pp. 4235 - 4243
• Main Authors: Ho, Nataschja I, Camps, Marcel G M, de Haas, Edwin F E, Trouw, Leendert A, Verbeek, J Sjef, Ossendorp, Ferry
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 01.06.2017
• Subjects: Adaptive Immunity; Animals; Antigen Presentation; Antigen-Antibody Complex - immunology; Antigen-presenting cells; CD8 Antigens - immunology; Cell surface; Complement C1q - deficiency; Complement C1q - genetics; Complement C1q - immunology; Complement component C1q; Cross-Priming; Dendritic cells; Dendritic Cells - immunology; Lymphocytes; Lymphocytes T; Mice; Mice, Inbred C57BL; Receptors, IgG - immunology; Spleen

Dendritic cells (DCs) are specialized in Ag engulfment via a wide variety of uptake receptors on their cell surface. In the present study we investigated Ag uptake and presentation of in vivo-formed Ag-Ab complexes by i.v. injecting mice with Ag-specific Abs followed by the cognate Ag. We show by th...